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anti-PTTG1 antibody :: Rabbit PTTG1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2524090
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PTTG1, Polyclonal Antibody

★Popular Item★
 Also Known As   

PTTG1 Polyclonal Antibody

 Product Synonym Names    EAP1; PTTG; HPTTG; TUTR1
 Product Gene Name   

anti-PTTG1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q6IAL9
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    2.1mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human PTTG1
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PTTG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PTTG1 antibody

   The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
 Product Categories/Family for anti-PTTG1 antibody    Cell biology; Epigenetics
 Applications Tested/Suitable for anti-PTTG1 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-PTTG1 antibody    IHC: 1:100-1:300
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 Immunohistochemistry (IHC) of anti-PTTG1 antibody    Immunohistochemistry of paraffin-embedded Human breast cancer tissue using PTTG1 Polyclonal Antibody at dilution 1:60
anti-PTTG1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PTTG1 antibody    Immunohistochemistry of paraffin-embedded Human lung cancer tissue using PTTG1 Polyclonal Antibody at dilution 1:60
anti-PTTG1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PTTG1. It may not necessarily be applicable to this product.
 NCBI GI #    49456331
 NCBI GeneID    9232
 NCBI Accession #    CAG46486.1 [Other Products]
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 UniProt Primary Accession #    Q6IAL9 [Other Products]
 UniProt Related Accession #    O95997 [Other Products]
 Molecular Weight    22,024 Da
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 NCBI Official Full Name    PTTG1, partial
 NCBI Official Synonym Full Names    pituitary tumor-transforming 1
 NCBI Official Symbol    PTTG1 [Similar Products]
 NCBI Official Synonym Symbols   
EAP1; PTTG; HPTTG; TUTR1
[Similar Products]
 NCBI Protein Information    securin; ESP1-associated protein 1; pituitary tumor-transforming gene 1 protein; tumor-transforming protein 1
 UniProt Protein Name    PTTG1 protein
 UniProt Synonym Protein Names   
PTTG1 protein
 UniProt Gene Name    PTTG1 [Similar Products]
 UniProt Entry Name    Q6IAL9_HUMAN
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 NCBI Summary for PTTG1    The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
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 UniProt Comments for PTTG1    Securin: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. Belongs to the securin family.

Protein type: Cell cycle regulation; Oncoprotein

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: protein binding; cysteine protease inhibitor activity; SH3 domain binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; mitosis; regulation of transcription, DNA-dependent; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; spermatogenesis; mitotic cell cycle; DNA repair; chromosome organization and biogenesis; chromosome segregation
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 Research Articles on PTTG1    1. The numbers of migrating cells (51.38 +/- 4.71) in the PTTG siRNA group was obviously lower.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PTTG1 antibodyDiseases associated with anti-PTTG1 antibody
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >90 publications with PTTG1 and Carcinoma
 Adenoma Antibodies  >51 publications with PTTG1 and Adenoma
 Cell Transformation, Neoplastic Antibodies  >48 publications with PTTG1 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >47 publications with PTTG1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >41 publications with PTTG1 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >36 publications with PTTG1 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >26 publications with PTTG1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >24 publications with PTTG1 and Neoplasms, Experimental
 Hyperplasia Antibodies  >21 publications with PTTG1 and Hyperplasia
 Liver Neoplasms Antibodies  >18 publications with PTTG1 and Liver Neoplasms
Organs/Tissues associated with anti-PTTG1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >50 publications with PTTG1 and Brain
 Lung Antibodies  >34 publications with PTTG1 and Lung
 Blood Antibodies  >34 publications with PTTG1 and Blood
 Liver Antibodies  >32 publications with PTTG1 and Liver
 Vascular Antibodies  >30 publications with PTTG1 and Vascular
 Testis Antibodies  >23 publications with PTTG1 and Testis
 Lymph Node Antibodies  >22 publications with PTTG1 and Lymph Node
 Lymph Antibodies  >22 publications with PTTG1 and Lymph
 Kidney Antibodies  >19 publications with PTTG1 and Kidney
 Prostate Antibodies  >18 publications with PTTG1 and Prostate
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