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anti-Bbc3 antibody :: Rabbit PUMA (CT) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS194335 anti-Bbc3 antibody
Unit / Price
0.1 mg  /  $390 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PUMA (CT) (Bbc3), Polyclonal Antibody

★Popular Item★
 Also Known As   

PUMA (CT) Polyclonal Antibody

 Product Synonym Names    PUMA (CT)
 Product Gene Name   

anti-Bbc3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q80ZG6
 Clonality    Polyclonal
 Host    Rabbit
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 Specificity    PUMA (CT) [This rabbit antibody recognizes an epitope of aa 180-193 at the C-terminus of human and mouse PUMA (p53 Upregulated Modulator of Apoptosis).]
This antibody recognizes an epitope at the C-terminus of human and mouse PUMA (p53 Upregulated Modulator of Apoptosis). PUMA is a pro-apoptotic Bcl-2 family member that encodes two BH3 domain-containing proteins, PUMA- alpha and PUMA- beta . PUMA proteins bind Bcl-2, localize to mitochondria, and induce cytochrome c release and apoptosis in response to p53.
 Form/Format    100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
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 Antigen    Peptide corresponding to aa 180-193 of human PUMA- alpha . This sequence is identical in human PUMA- alpha and PUMA- beta .
 Stabilizer    None
 Preservatives    0.02% sodium azide
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of anti-Bbc3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-Bbc3 antibody    Apoptosis Antibodies
 Applications Tested/Suitable for anti-Bbc3 antibody   


 Application Notes for anti-Bbc3 antibody    Immunoblotting: use at 1-2 ug/ml. In immunoblots, a band of 23 kD is detected. A lower molecular weight band at 16 kD is detected in MOLT4 and U937 cell lysates and probably represents the PUMA- beta protein.
Positive control: Raji cell lysate.
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NCBI/Uniprot data below describe general gene information for Bbc3. It may not necessarily be applicable to this product.
 NCBI GI #    27542559
 NCBI GeneID    317673
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 UniProt Primary Accession #    Q80ZG6 [Other Products]
 UniProt Related Accession #    Q80ZG6 [Other Products]
 Molecular Weight    20,718 Da [Similar Products]
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 NCBI Official Full Name    PUMA
 NCBI Official Synonym Full Names    Bcl-2 binding component 3
 NCBI Official Symbol    Bbc3 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    bcl-2-binding component 3; p53 up-regulated modulator of apoptosis
 UniProt Protein Name    Bcl-2-binding component 3
 UniProt Synonym Protein Names   
p53 up-regulated modulator of apoptosis
 Protein Family    Bcl-2-binding component
 UniProt Gene Name    Bbc3 [Similar Products]
 UniProt Synonym Gene Names    Puma [Similar Products]
 UniProt Entry Name    BBC3_RAT
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 UniProt Comments for Bbc3    PUMA: Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Interacts with MCL1 and BCL2A1. Interacts with BCL2 and BCL2L1/BCL-XL. By DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. Ubiquitously expressed. Belongs to the Bcl-2 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial

Cellular Component: mitochondrion; intracellular

Molecular Function: protein binding

Biological Process: caspase activation; release of cytochrome c from mitochondria; glial cell differentiation; positive regulation of protein homooligomerization; positive regulation of apoptosis; release of sequestered calcium ion into cytosol; positive regulation of neuron apoptosis; reduction of endoplasmic reticulum calcium ion concentration; determination of adult life span; brain development; response to DNA damage stimulus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of growth
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 Research Articles on Bbc3    1. Data show that transcriptional activation of PUMA is regulated by nuclear factor-kappaB and endoplasmic reticulum stress.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Bbc3 antibodyDiseases associated with anti-Bbc3 antibody
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >155 publications with Bbc3 and Neoplasms
 Leukemia Antibodies  >44 publications with Bbc3 and Leukemia
 Carcinoma Antibodies  >36 publications with Bbc3 and Carcinoma
 Gastrointestinal Neoplasms Antibodies  >34 publications with Bbc3 and Gastrointestinal Neoplasms
 Intestinal Diseases Antibodies  >30 publications with Bbc3 and Intestinal Diseases
 Intestinal Neoplasms Antibodies  >29 publications with Bbc3 and Intestinal Neoplasms
 Colorectal Neoplasms Antibodies  >29 publications with Bbc3 and Colorectal Neoplasms
 Leukemia, Myeloid Antibodies  >25 publications with Bbc3 and Leukemia, Myeloid
 Neuroectodermal Tumors Antibodies  >22 publications with Bbc3 and Neuroectodermal Tumors
 Adenocarcinoma Antibodies  >19 publications with Bbc3 and Adenocarcinoma
Organs/Tissues associated with anti-Bbc3 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >4 publications with Bbc3 and Kidney
 Mixed Antibodies  >1 publications with Bbc3 and Mixed
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