AAO16862.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
20,718 Da
NCBI Official Full Name
PUMA
NCBI Official Synonym Full Names
Bcl-2 binding component 3
NCBI Official Synonym Symbols
NCBI Protein Information
bcl-2-binding component 3
UniProt Protein Name
Bcl-2-binding component 3
UniProt Synonym Protein Names
p53 up-regulated modulator of apoptosis
UniProt Synonym Gene Names
UniProt Entry Name
BBC3_RAT
UniProt Comments for PUMA
PUMA: Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Interacts with MCL1 and BCL2A1. Interacts with BCL2 and BCL2L1/BCL-XL. By DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. Ubiquitously expressed. Belongs to the Bcl-2 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial
Cellular Component: mitochondrion; intracellular
Molecular Function: protein binding
Biological Process: caspase activation; release of cytochrome c from mitochondria; positive regulation of protein homooligomerization; positive regulation of apoptosis; determination of adult life span; glial cell differentiation; release of sequestered calcium ion into cytosol; reduction of endoplasmic reticulum calcium ion concentration; positive regulation of neuron apoptosis; brain development; response to DNA damage stimulus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of growth
Research Articles on PUMA
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Pathways associated with anti-PUMA antibody
Diseases associated with anti-PUMA antibody
Organs/Tissues associated with anti-PUMA antibody
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