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anti-PAX6 antibody :: Rabbit anti-Human Paired box protein Pax-6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1494593
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Paired box protein Pax-6 (PAX6), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Paired box protein Pax-6 polyclonal Antibody(PAX6)

 Product Synonym Names    Aniridia type II protein; Oculorhombin; PAX6; AN2
 Product Gene Name   

anti-PAX6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    106210
 3D Structure    ModBase 3D Structure for P26367
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Paired box protein Pax-6 protein (1-300aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7750 / sc-7751 / sc-11357
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PAX6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PAX6 antibody

   Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
 Applications Tested/Suitable for anti-PAX6 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PAX6 antibody    Recommended dilution: WB:1:500-2000
IHC:1:20-1:200
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 Western Blot (WB) of anti-PAX6 antibody    All lanes: Paired box protein Pax-6 antibody at 1ug/ml
Lane 1:mouse stomach tissue
Lane 2:mouse eye tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 47,49 kDa
Observed band size: 47 kDa

anti-PAX6 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PAX6 antibody    Immunohistochemistry of paraffin-embedded human lung cancer using MBS1494593 at dilution 1:100
anti-PAX6 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PAX6 antibody    Immunohistochemistry of paraffin-embedded human pancreas using MBS1494593 at dilution 1:100
anti-PAX6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PAX6. It may not necessarily be applicable to this product.
 NCBI GI #    4505615
 NCBI GeneID    5080
 NCBI Accession #    NP_000271.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000280.4 [Other Products]
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 UniProt Primary Accession #    P26367 [Other Products]
 UniProt Secondary Accession #    Q6N006; Q99413 [Other Products]
 UniProt Related Accession #    P26367 [Other Products]
 Molecular Weight    – Da
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 NCBI Official Full Name    paired box protein Pax-6 isoform a
 NCBI Official Synonym Full Names    paired box 6
 NCBI Official Symbol    PAX6 [Similar Products]
 NCBI Official Synonym Symbols   
AN; AN2; FVH1; MGDA; WAGR; D11S812E
[Similar Products]
 NCBI Protein Information    paired box protein Pax-6
 UniProt Protein Name    Paired box protein Pax-6
 UniProt Synonym Protein Names   
Aniridia type II protein; Oculorhombin
 Protein Family    Paired box protein
 UniProt Gene Name    PAX6 [Similar Products]
 UniProt Synonym Gene Names    AN2 [Similar Products]
 UniProt Entry Name    PAX6_HUMAN
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 NCBI Summary for PAX6    This gene encodes a homeobox and paired domain-containing protein that binds DNA and functions as a regulator of transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
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 UniProt Comments for PAX6    PAX6: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Isoform 5a appears to function as a molecular switch that specifies target genes. Defects in PAX6 are the cause of aniridia (AN). A congenital, bilateral, panocular disorder characterized by complete absence of the iris or extreme iris hypoplasia. Aniridia is not just an isolated defect in iris development but it is associated with macular and optic nerve hypoplasia, cataract, corneal changes, nystagmus. Visual acuity is generally low but is unrelated to the degree of iris hypoplasia. Glaucoma is a secondary problem causing additional visual loss over time. Defects in PAX6 are a cause of Peters anomaly (PAN). Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea. Defects in PAX6 are a cause of foveal hypoplasia (FOVHYP). Foveal hypoplasia can be isolated or associated with presenile cataract. Inheritance is autosomal dominant. Defects in PAX6 are a cause of keratitis hereditary (KERH). An ocular disorder characterized by corneal opacification, recurrent stromal keratitis and vascularization. Defects in PAX6 are a cause of coloboma of iris choroid and retina (COI); also known as uveoretinal coloboma. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Severe colobomatous malformations may cause as much as 10% of the childhood blindness. The clinical presentation of ocular coloboma is variable. Some individuals may present with minimal defects in the anterior iris leaf without other ocular defects. More complex malformations create a combination of iris, uveoretinal and/or optic nerve defects without or with microphthalmia or even anophthalmia. Defects in PAX6 are a cause of coloboma of optic nerve (COLON). Defects in PAX6 are a cause of bilateral optic nerve hypoplasia (BONH); also known as bilateral optic nerve aplasia. A congenital anomaly in which the optic disc appears abnormally small. It may be an isolated finding or part of a spectrum of anatomic and functional abnormalities that includes partial or complete agenesis of the septum pellucidum, other midline brain defects, cerebral anomalies, pituitary dysfunction, and structural abnormalities of the pituitary. Defects in PAX6 are a cause of aniridia cerebellar ataxia and mental deficiency (ACAMD); also known as Gillespie syndrome. A rare condition consisting of partial rudimentary iris, cerebellar impairment of the ability to perform coordinated voluntary movements, and mental retardation. Belongs to the paired homeobox family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus

Molecular Function: chromatin binding; DNA binding; histone acetyltransferase binding; protein binding; protein kinase binding; transcription factor activity; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: astrocyte differentiation; axon guidance; blood vessel development; cell fate determination; central nervous system development; cerebral cortex regionalization; commitment of a neuronal cell to a specific type of neuron in the forebrain; dorsal/ventral axis specification; embryonic camera-type eye morphogenesis; establishment of mitotic spindle orientation; eye development; eye photoreceptor cell development; forebrain anterior/posterior pattern formation; forebrain dorsal/ventral pattern formation; forebrain-midbrain boundary formation; glucose homeostasis; keratinocyte differentiation; lacrimal gland development; lens development in camera-type eye; negative regulation of epithelial cell proliferation; negative regulation of neurogenesis; negative regulation of neuron differentiation; negative regulation of protein amino acid phosphorylation; negative regulation of transcription from RNA polymerase II promoter; neuron fate commitment; neuron migration; oligodendrocyte cell fate specification; organ morphogenesis; pituitary gland development; positive regulation of epithelial cell differentiation; positive regulation of neuroblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein localization in organelle; protein ubiquitination; regulation of asymmetric cell division; regulation of cell migration; regulation of timing of cell differentiation; regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment; regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; response to wounding; retina development in camera-type eye; salivary gland morphogenesis; smoothened signaling pathway; transcription from RNA polymerase II promoter; visual perception

Disease: Aniridia; Aniridia, Cerebellar Ataxia, And Mental Retardation; Coloboma Of Optic Nerve; Foveal Hypoplasia 1; Keratitis, Hereditary; Optic Nerve Hypoplasia, Bilateral; Peters Anomaly; Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome
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 Research Articles on PAX6    1. the case of a Korean family with novel splice site mutation in the PAX6 gene in isolated aniridia inherited in an autosomal dominant manner, is reported.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PAX6 antibodyPathways associated with anti-PAX6 antibody
 Reference Product  PubMed Publications
 SOX2 antibody  >209 publications with PAX6 and SOX2
 SIX3 antibody  >90 publications with PAX6 and SIX3
 NKX2-2 antibody  >83 publications with PAX6 and NKX2-2
 NEUROD1 antibody  >55 publications with PAX6 and NEUROD1
 BMP4 antibody  >42 publications with PAX6 and BMP4
 FOXA2 antibody  >27 publications with PAX6 and FOXA2
 SIX6 antibody  >22 publications with PAX6 and SIX6
 INS antibody  >13 publications with PAX6 and INS
 GCG antibody  >4 publications with PAX6 and GCG
 Products by Pathway  Pathway Diagram
 Activation Of HOX Genes During Differentiation Pathway antibodies  Activation Of HOX Genes During Differentiation Pathway Diagram
 Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway antibodies  Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Incretin Synthesis, Secretion, And Inactivation Pathway antibodies  Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
Diseases associated with anti-PAX6 antibodyOrgans/Tissues associated with anti-PAX6 antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >427 publications with PAX6 and Congenital Abnormalities
 Aniridia Antibodies  >306 publications with PAX6 and Aniridia
 Nervous System Diseases Antibodies  >199 publications with PAX6 and Nervous System Diseases
 Brain Diseases Antibodies  >80 publications with PAX6 and Brain Diseases
 Intellectual Disability Antibodies  >45 publications with PAX6 and Intellectual Disability
 Nervous System Malformations Antibodies  >45 publications with PAX6 and Nervous System Malformations
 Peters anomaly Antibodies  >41 publications with PAX6 and Peters anomaly
 Coloboma Antibodies  >36 publications with PAX6 and Coloboma
 Craniofacial Abnormalities Antibodies  >30 publications with PAX6 and Craniofacial Abnormalities
 Necrosis Antibodies  >17 publications with PAX6 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >1933 publications with PAX6 and Eye
 Brain Antibodies  >809 publications with PAX6 and Brain
 Embryonic Tissue Antibodies  >403 publications with PAX6 and Embryonic Tissue
 Pancreas Antibodies  >234 publications with PAX6 and Pancreas
 Muscle Antibodies  >56 publications with PAX6 and Muscle
 Kidney Antibodies  >35 publications with PAX6 and Kidney
 Skin Antibodies  >28 publications with PAX6 and Skin
 Mouth Antibodies  >18 publications with PAX6 and Mouth
 Lung Antibodies  >16 publications with PAX6 and Lung
 Intestine Antibodies  >15 publications with PAX6 and Intestine
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