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anti-PPY antibody :: Goat Pancreatic Polypeptide/PPY Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420040
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pancreatic Polypeptide/PPY, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-Pancreatic Polypeptide/PPY Antibody

 Product Synonym Names    PPY; pancreatic polypeptide; HGNC: 9327; PNP; pancreatic polypeptide Y; PPY antibody; pancreatic polypeptide antibody; HGNC: 9327 antibody; PNP antibody; pancreatic polypeptide Y antibody; Pancreatic Polypeptide; Pancreatic Polypeptide / PPY
 Product Gene Name   

anti-PPY antibody

[Similar Products]
 Antibody/Peptide Pairs    Pancreatic Polypeptide / PPY peptide (MBS426352) is used for blocking the activity of Pancreatic Polypeptide/PPY antibody (MBS420040)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    TRPRYGKRHK EDT
 OMIM    167780
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-TRPRYGKRHKEDT, from the internal region of the protein sequence according to NP_002713.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-PPY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PPY antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-PPY antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded human pancreas, shows strong cytoplasmic staining of rare cells located at the periphery of islets of Langerhans. Recommended concentration, 3ug/ml. An anonymous customer found positive results in IHC on Mouse pancreas.
Western Blot: Preliminary experiments gave an approx 35-38kDa band in human pancreas lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 10.5kDa according to NP_002713.1. The 38kDa band was successfully blocked by incubation with the immunizing peptide.
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 Immunohistochemistry (IHC) of anti-PPY antibody    (3ug/ml) staining of paraffin embedded human pancreas. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.
anti-PPY antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PPY. It may not necessarily be applicable to this product.
 NCBI GI #    4506033
 NCBI GeneID    5539
 NCBI Accession #    NP_002713.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002722.4 [Other Products]
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 UniProt Related Accession #    P01298 [Other Products]
 Molecular Weight    18,786 Da
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 NCBI Official Full Name    pancreatic prohormone isoform 1 preproprotein
 NCBI Official Synonym Full Names    pancreatic polypeptide
 NCBI Official Symbol    PPY [Similar Products]
 NCBI Official Synonym Symbols   
PP; PNP
[Similar Products]
 NCBI Protein Information    pancreatic prohormone
 UniProt Protein Name    Pancreatic prohormone
 UniProt Synonym Protein Names   
Pancreatic polypeptide; PP
 Protein Family    Pancreatic hormone
 UniProt Gene Name    PPY [Similar Products]
 UniProt Synonym Gene Names    PNP; PP; PH; PI [Similar Products]
 UniProt Entry Name    PAHO_HUMAN
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 NCBI Summary for PPY    This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
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 UniProt Comments for PPY    PPY: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. Belongs to the NPY family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytoplasm; extracellular region; extracellular space

Molecular Function: G-protein-coupled receptor binding; hormone activity; neuropeptide hormone activity; receptor binding

Biological Process: cell-cell signaling; digestion; feeding behavior; neuropeptide signaling pathway; positive regulation of defense response to virus by host; protein secretion; regulation of appetite
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 Research Articles on PPY    1. Immunohistochemical distribution of this peptide in the epidermal skin (from abdomen, breast and face) of healthy women was analysed.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PPY antibodyPathways associated with anti-PPY antibody
 Reference Product  PubMed Publications
 SST antibody  >5 publications with PPY and SST
 GHRL antibody  >3 publications with PPY and GHRL
 NPY2R antibody  >2 publications with PPY and NPY2R
 GAL antibody  >2 publications with PPY and GAL
 NPY5R antibody  >1 publications with PPY and NPY5R
 NPY1R antibody  >1 publications with PPY and NPY1R
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with anti-PPY antibodyOrgans/Tissues associated with anti-PPY antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >14 publications with PPY and Cardiovascular Diseases
 Inflammation Antibodies  >14 publications with PPY and Inflammation
 Necrosis Antibodies  >12 publications with PPY and Necrosis
 Diabetes Mellitus, Type 2 Antibodies  >8 publications with PPY and Diabetes Mellitus, Type 2
 Disease Models, Animal Antibodies  >7 publications with PPY and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >5 publications with PPY and Neoplasms, Experimental
 Liver Diseases Antibodies  >4 publications with PPY and Liver Diseases
 Diabetes Mellitus, Type 1 Antibodies  >3 publications with PPY and Diabetes Mellitus, Type 1
 Hemorrhage Antibodies  >3 publications with PPY and Hemorrhage
 Hyperplasia Antibodies  >3 publications with PPY and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >17 publications with PPY and Pancreas
 Connective Tissue Antibodies  >13 publications with PPY and Connective Tissue
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