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anti-PANK1 antibody :: Rabbit anti-Human, Mouse Pantothenate Kinase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS625341 anti-PANK1 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pantothenate Kinase 1 (PANK1), Polyclonal Antibody

 Also Known As   

Pantothenate Kinase 1, NT (Pantothenic Acid Kinase 1, PANK1, PANK1a, PANK1b, PANK, hPanK1, hPanK, MGC24596)

 Product Synonym Names    Anti -Pantothenate Kinase 1, NT (Pantothenic Acid Kinase 1, PANK1, PANK1a, PANK1b, PANK, hPanK1, hPanK, MGC24596)
 Product Gene Name   

anti-PANK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (91342749..91405215, complement). Location: 10q23.31
 OMIM    606160
 3D Structure    ModBase 3D Structure for Q8TE04
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Recognizes human PANK1. Species Crossreactivity: mouse.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    Synthetic peptide selected from the N-terminal region of human PANK1 (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-PANK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PANK1 antibody

   PANK1 belongs to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA.
 Product Categories/Family for anti-PANK1 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-PANK1 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-PANK1 antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
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NCBI/Uniprot data below describe general gene information for PANK1. It may not necessarily be applicable to this product.
 NCBI GI #    55957270
 NCBI GeneID    53354
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 UniProt Primary Accession #    Q8TE04 [Other Products]
 UniProt Secondary Accession #    Q7RTX6; Q7Z495; Q8TBQ8; A6NIP0 [Other Products]
 UniProt Related Accession #    Q8TE04 [Other Products]
 Molecular Weight    64,339 Da [Similar Products]
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 NCBI Official Full Name    pantothenate kinase 1
 NCBI Official Synonym Full Names    pantothenate kinase 1
 NCBI Official Symbol    PANK1 [Similar Products]
 NCBI Official Synonym Symbols   
PANK; MGC24596
[Similar Products]
 NCBI Protein Information    pantothenate kinase 1; OTTHUMP00000020071; OTTHUMP00000020072; pantothenic acid kinase 1
 UniProt Protein Name    Pantothenate kinase 1
 UniProt Synonym Protein Names   
Pantothenic acid kinase 1
 Protein Family    Pantothenate kinase
 UniProt Gene Name    PANK1 [Similar Products]
 UniProt Synonym Gene Names    PANK [Similar Products]
 UniProt Entry Name    PANK1_HUMAN
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 NCBI Summary for PANK1    This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq]
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 UniProt Comments for PANK1    PANK1: Plays a role in the physiological regulation of the intracellular CoA concentration. Belongs to the type II pantothenate kinase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.1.33; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Kinase, other

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: recycling endosome; clathrin coat; cytosol; nucleus

Molecular Function: pantothenate kinase activity; ATP binding

Biological Process: coenzyme biosynthetic process; coenzyme A biosynthetic process; vitamin metabolic process; pantothenate metabolic process; phosphorylation; water-soluble vitamin metabolic process
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 Research Articles on PANK1    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PANK1 antibodyDiseases associated with anti-PANK1 antibody
 Products by Pathway  Pathway Diagram
 Coenzyme A Biosynthesis Pathway antibodies  Coenzyme A Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Vitamin B5 (pantothenate) Metabolism Pathway antibodies  Vitamin B5 (pantothenate) Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >1 publications with PANK1 and Liver Diseases
 Hyperglycemia Antibodies  >1 publications with PANK1 and Hyperglycemia
 Central Nervous System Diseases Antibodies  >1 publications with PANK1 and Central Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >1 publications with PANK1 and Neurodegenerative Diseases
 Fatty Liver Antibodies  >1 publications with PANK1 and Fatty Liver
Organs/Tissues associated with anti-PANK1 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with PANK1 and Liver
 Brain Antibodies  >1 publications with PANK1 and Brain
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