NP_002572.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
pappalysin-1 preproprotein
NCBI Official Synonym Full Names
pregnancy-associated plasma protein A, pappalysin 1
NCBI Official Synonym Symbols
PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase [Similar Products]
NCBI Protein Information
pappalysin-1
UniProt Protein Name
Pappalysin-1
UniProt Synonym Protein Names
Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase; Pregnancy-associated plasma protein A; PAPP-A
UniProt Synonym Gene Names
UniProt Entry Name
PAPP1_HUMAN
NCBI Summary for PAPPA
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]
UniProt Comments for PAPPA
PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family.
Protein type: EC 3.4.24.79; Secreted, signal peptide; Protease; Secreted
Chromosomal Location of Human Ortholog: 9q33.2
Cellular Component: extracellular region
Molecular Function: metalloendopeptidase activity; metallopeptidase activity; zinc ion binding
Biological Process: cellular protein metabolic process; female pregnancy; proteolysis
Research Articles on PAPPA
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Products associated with anti-PAPPA antibody
Pathways associated with anti-PAPPA antibody
Diseases associated with anti-PAPPA antibody
Organs/Tissues associated with anti-PAPPA antibody
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