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anti-PTH antibody :: Rabbit anti-Human Parathyroid hormone Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7001920
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Parathyroid hormone (PTH), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Parathyroid hormone polyclonal Antibody

 Product Synonym Names    Parathyroid hormone protein; Parathormone; Parathyrin; PTH
 Product Gene Name   

anti-PTH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146200
 3D Structure    ModBase 3D Structure for P01270
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Parathyroid hormone protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9677 / sc-9678 / sc-9676 / sc-28922 / sc-28922
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PTH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PTH antibody

   PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.

This protein is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH).
 Product Categories/Family for anti-PTH antibody    Signal Transduction
 Applications Tested/Suitable for anti-PTH antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-PTH antibody    Recommended dilution: WB:1:500-2000
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 Immunohistochemistry (IHC) of anti-PTH antibody    IHC image of MBS7001920 diluted at 1:700 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
anti-PTH antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PTH antibody    IHC image of MBS7001920 diluted at 1:700 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 degree C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
anti-PTH antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PTH. It may not necessarily be applicable to this product.
 NCBI GI #    4506267
 NCBI GeneID    5741
 NCBI Accession #    NP_000306.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000315.3 [Other Products]
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 UniProt Primary Accession #    P01270 [Other Products]
 UniProt Secondary Accession #    Q4VB48; Q9UD38 [Other Products]
 UniProt Related Accession #    P01270 [Other Products]
 Molecular Weight    12,861 Da
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 NCBI Official Full Name    parathyroid hormone isoform 1 preproprotein
 NCBI Official Synonym Full Names    parathyroid hormone
 NCBI Official Symbol    PTH [Similar Products]
 NCBI Official Synonym Symbols   
PTH1
[Similar Products]
 NCBI Protein Information    parathyroid hormone
 UniProt Protein Name    Parathyroid hormone
 UniProt Synonym Protein Names   
Parathormone; Parathyrin
 Protein Family    Parathyroid hormone
 UniProt Gene Name    PTH [Similar Products]
 UniProt Synonym Gene Names    PTH [Similar Products]
 UniProt Entry Name    PTHY_HUMAN
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 NCBI Summary for PTH    This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
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 UniProt Comments for PTH    PTH: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Belongs to the parathyroid hormone family.

Protein type: Secreted; Secreted, signal peptide; Apoptosis; Hormone

Chromosomal Location of Human Ortholog: 11p15.3-p15.1

Cellular Component: extracellular region; extracellular space; intracellular

Molecular Function: hormone activity; parathyroid hormone receptor binding; peptide hormone receptor binding; RNA polymerase II transcription factor activity, enhancer binding; type 1 parathyroid hormone receptor binding

Biological Process: bone resorption; cAMP metabolic process; cell-cell signaling; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase activating pathway; induction of apoptosis by hormones; negative regulation of transcription from RNA polymerase II promoter; positive regulation of bone mineralization; positive regulation of cAMP biosynthetic process; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of signal transduction; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression; response to cadmium ion; response to drug; response to ethanol; response to lead ion; response to vitamin D; Rho protein signal transduction; skeletal development

Disease: Hypoparathyroidism, Familial Isolated
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 Research Articles on PTH    1. the iPTH level in ESRD patients carrying VDR BsmI Bb genotype was higher than that in ESRD patients carrying bb genotype in overall populations and in Caucasians
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PTH antibodyPathways associated with anti-PTH antibody
 Reference Product  PubMed Publications
 PTHLH antibody  >449 publications with PTH and PTHLH
 FGF23 antibody  >310 publications with PTH and FGF23
 CASR antibody  >260 publications with PTH and CASR
 PTH1R antibody  >230 publications with PTH and PTH1R
 AVP antibody  >62 publications with PTH and AVP
 PTH2R antibody  >18 publications with PTH and PTH2R
 CALCA antibody  >7 publications with PTH and CALCA
 BGLAP antibody  >3 publications with PTH and BGLAP
 GCG antibody  >1 publications with PTH and GCG
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Osteoblast Signaling Pathway antibodies  Osteoblast Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Vitamin D Synthesis Pathway antibodies  Vitamin D Synthesis Pathway Diagram
Diseases associated with anti-PTH antibodyOrgans/Tissues associated with anti-PTH antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3520 publications with PTH and Kidney Diseases
 Hyperparathyroidism, Secondary Antibodies  >2975 publications with PTH and Hyperparathyroidism, Secondary
 Bone Diseases, Metabolic Antibodies  >2783 publications with PTH and Bone Diseases, Metabolic
 Hypercalcemia Antibodies  >2530 publications with PTH and Hypercalcemia
 Bone Resorption Antibodies  >2319 publications with PTH and Bone Resorption
 Renal Insufficiency Antibodies  >2295 publications with PTH and Renal Insufficiency
 Osteoporosis Antibodies  >2221 publications with PTH and Osteoporosis
 Hypocalcemia Antibodies  >1479 publications with PTH and Hypocalcemia
 Cardiovascular Diseases Antibodies  >1000 publications with PTH and Cardiovascular Diseases
 Fractures, Bone Antibodies  >934 publications with PTH and Fractures, Bone
 Organ/Tissue Name  Pubmed Publications
 Parathyroid Antibodies  >16233 publications with PTH and Parathyroid
 Connective Tissue Antibodies  >2471 publications with PTH and Connective Tissue
 Embryonic Tissue Antibodies  >243 publications with PTH and Embryonic Tissue
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