NP_598676.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
paxillin isoform beta
NCBI Official Synonym Full Names
paxillin
NCBI Protein Information
paxillin
UniProt Protein Name
Paxillin
UniProt Entry Name
PAXI_MOUSE
UniProt Comments for Pxn
Function: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion)
By similarity.
Subunit structure: Interacts with VCL and SRC (via SH3 domain). Interacts with GIT1, NUDT16L1/SDOS and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds ASAP2. Interacts with RNF5 and PDCD10
By similarity. Interacts with SORBS1, PARVA and PARVB. Interacts with NEK3 and this interaction is prolactin-dependent
By similarity. Interacts with PTK2/FAK1. Interacts with PTK6
By similarity. Interacts with PTK2B/PYK2. Ref.3 Ref.5 Ref.6
Subcellular location: Cytoplasm › cytoskeleton
By similarity. Cell junction › focal adhesion
By similarity. Cytoplasm › cell cortex. Note: Colocalizes with integrins at the cell periphery. Ref.3
Post-translational modification: Phosphorylated by MAPK1/ERK2. Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation
By similarity. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion
By similarity. Ref.4 Ref.10
Sequence similarities: Belongs to the paxillin family.Contains 4 LIM zinc-binding domains.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-Pxn antibody
Diseases associated with anti-Pxn antibody
Organs/Tissues associated with anti-Pxn antibody
|