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anti-ATG16L1 antibody :: Rabbit anti-Human Phospho-ATG16L (S287) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9205635
Dot Blot (DB)
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 Product Name   

Phospho-ATG16L (S287) (ATG16L1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Phospho-ATG16L (S287) Antibody

 Product Synonym Names    Autophagy-related protein 16-1; APG16-like 1; ATG16L1; APG16L
 Product Gene Name   

anti-ATG16L1 antibody

[Similar Products]
 Antibody/Peptide Pairs    ATG16L (S287) peptide (MBS9225110) is used for blocking the activity of ATG16L (S287) antibody (MBS9205635)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610767
 3D Structure    ModBase 3D Structure for Q676U5
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This ATG16L Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S287 of human ATG16L.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.45 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-ATG16L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ATG16L1 antibody

   Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole).

The APG12-APG5-APG16L complex is essential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane.
 Product Categories/Family for anti-ATG16L1 antibody    Cancer; Cardiovascular; Cell Biology; Metabolism; Phospho Antibodies
 Applications Tested/Suitable for anti-ATG16L1 antibody   

Dot Blot (DB), ELISA (EIA)

 Application Notes for anti-ATG16L1 antibody    DB~~1:500
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 Dot Blot (DB) of anti-ATG16L1 antibody    Dot blot analysis of Phospho-APG16L-S287 Antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
anti-ATG16L1 antibody Dot Blot (DB) image
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NCBI/Uniprot data below describe general gene information for ATG16L1. It may not necessarily be applicable to this product.
 NCBI GI #    298229005
 NCBI GeneID    55054
 NCBI Accession #    NP_001177195.1 [Other Products]
 NCBI Related Accession #    NP_001177196.1; NP_060444.3; NP_110430.5; NP_942593.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190266.1 [Other Products]
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 UniProt Primary Accession #    Q676U5 [Other Products]
 UniProt Secondary Accession #    Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619; A3EXK9; A3EXL0; B6ZDH0 [Other Products]
 UniProt Related Accession #    Q676U5 [Other Products]
 Molecular Weight    68265
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 NCBI Official Full Name    autophagy-related protein 16-1 isoform 4
 NCBI Official Synonym Full Names    autophagy related 16-like 1
 NCBI Official Symbol    ATG16L1 [Similar Products]
 NCBI Official Synonym Symbols   
IBD10; WDR30; APG16L; ATG16A; ATG16L
[Similar Products]
 NCBI Protein Information    autophagy-related protein 16-1
 UniProt Protein Name    Autophagy-related protein 16-1
 UniProt Synonym Protein Names   
APG16-like 1
 Protein Family    Autophagy-related protein
 UniProt Gene Name    ATG16L1 [Similar Products]
 UniProt Synonym Gene Names    APG16L [Similar Products]
 UniProt Entry Name    A16L1_HUMAN
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 NCBI Summary for ATG16L1    The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
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 UniProt Comments for ATG16L1    ATG16: Plays an essential role in autophagy. Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Belongs to the WD repeat ATG16 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Membrane protein, peripheral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: pre-autophagosomal structure membrane; autophagic vacuole; axoneme

Molecular Function: identical protein binding; protein binding

Biological Process: protein transport; protein homooligomerization; autophagic vacuole formation

Disease: Inflammatory Bowel Disease 10
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Product References and Citations for anti-ATG16L1 antibody

   Zheng H., DNA Seq. 15:303-305(2004).
Clark H.F., Genome Res. 13:2265-2270(2003).
Ota T., Nat. Genet. 36:40-45(2004).
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 Research Articles on ATG16L1    1. Data suggest ATG16L1 dimer interacts with WIPI2b (WD repeat domain phosphoinositide-interacting protein 2) and this interaction is linked to phosphatidylinositol 3-phosphate production in endoplasmic reticulum and autophagosome formation. [REVIEW]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ATG16L1 antibodyOrgans/Tissues associated with anti-ATG16L1 antibody
 Disease Name  Pubmed Publications
 Crohn Disease Antibodies  >184 publications with ATG16L1 and Crohn Disease
 Inflammation Antibodies  >76 publications with ATG16L1 and Inflammation
 Inflammatory Bowel Disease 10 Antibodies  >51 publications with ATG16L1 and Inflammatory Bowel Disease 10
 Necrosis Antibodies  >23 publications with ATG16L1 and Necrosis
 Disease Models, Animal Antibodies  >15 publications with ATG16L1 and Disease Models, Animal
 Liver Diseases Antibodies  >7 publications with ATG16L1 and Liver Diseases
 Death Antibodies  >7 publications with ATG16L1 and Death
 Fibrosis Antibodies  >4 publications with ATG16L1 and Fibrosis
 Hypertrophy Antibodies  >3 publications with ATG16L1 and Hypertrophy
 Hypertension Antibodies  >2 publications with ATG16L1 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >56 publications with ATG16L1 and Intestine
 Blood Antibodies  >35 publications with ATG16L1 and Blood
 Liver Antibodies  >11 publications with ATG16L1 and Liver
 Bone Antibodies  >7 publications with ATG16L1 and Bone
 Brain Antibodies  >7 publications with ATG16L1 and Brain
 Muscle Antibodies  >6 publications with ATG16L1 and Muscle
 Heart Antibodies  >5 publications with ATG16L1 and Heart
 Nerve Antibodies  >5 publications with ATG16L1 and Nerve
 Bone Marrow Antibodies  >4 publications with ATG16L1 and Bone Marrow
 Connective Tissue Antibodies  >3 publications with ATG16L1 and Connective Tissue
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