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anti-IL6ST antibody :: Rabbit anti-Human Phospho-IL6ST (Y905) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9201393
Dot Blot (DB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Phospho-IL6ST (Y905), Polyclonal Antibody

★Popular Item★
 Also Known As   

Phospho-IL6ST (Y905) Antibody

 Product Synonym Names    Interleukin-6 receptor subunit beta; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD130; IL6ST
 Product Gene Name   

anti-IL6ST antibody

[Similar Products]
 Antibody/Peptide Pairs    IL6ST (Y905) peptide (MBS9225218) is used for blocking the activity of IL6ST (Y905) antibody (MBS9201393)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600694
 3D Structure    ModBase 3D Structure for P40189
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This IL6ST Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y905 of human IL6ST.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
 Cellular Location    Isoform 1: Cell membrane; Single-pass type I membrane protein
 Tissue Location    Found in all the tissues and cell lines examined (PubMed: 2261637). Expression not restricted to IL6 responsive cells (PubMed: 2261637). Expressed in blood serum (at protein level) (PubMed: 24629561)
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-IL6ST antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL6ST antibody

   IL6ST is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein.
 Product Categories/Family for anti-IL6ST antibody    Cancer; Cardiovascular; Cell Biology; Metabolism; Autophagy
 Applications Tested/Suitable for anti-IL6ST antibody   

Dot Blot (DB), ELISA (EIA)

 Application Notes for anti-IL6ST antibody    DB~~1:500
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 Dot Blot (DB) of anti-IL6ST antibody    Dot blot analysis of anti-Phospho-IL6ST-Y905 Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
anti-IL6ST antibody Dot Blot (DB) image
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NCBI/Uniprot data below describe general gene information for IL6ST. It may not necessarily be applicable to this product.
 NCBI GI #    300244535
 NCBI GeneID    3572
 NCBI Accession #    NP_001177910.1 [Other Products]
 NCBI Related Accession #    NP_002175.2; NP_786943.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190981.1 [Other Products]
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 UniProt Primary Accession #    P40189 [Other Products]
 UniProt Secondary Accession #    Q5FC04; Q9UQ41; A0N0L4 [Other Products]
 UniProt Related Accession #    P40189 [Other Products]
 Molecular Weight    103537
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 NCBI Official Full Name    interleukin-6 receptor subunit beta isoform 3
 NCBI Official Synonym Full Names    interleukin 6 signal transducer
 NCBI Official Symbol    IL6ST [Similar Products]
 NCBI Official Synonym Symbols   
CD130; GP130; CDW130; IL-6RB
[Similar Products]
 NCBI Protein Information    interleukin-6 receptor subunit beta
 UniProt Protein Name    Interleukin-6 receptor subunit beta
 UniProt Synonym Protein Names   
CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD_antigen: CD130
 Protein Family    Interleukin-6 receptor
 UniProt Gene Name    IL6ST [Similar Products]
 UniProt Synonym Gene Names    IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; gp130 [Similar Products]
 UniProt Entry Name    IL6RB_HUMAN
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 NCBI Summary for IL6ST    The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
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 UniProt Comments for IL6ST    gp130: gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: extracellular space; cell soma; membrane; oncostatin-M receptor complex; dendrite; extracellular region; plasma membrane; interleukin-6 receptor complex; external side of plasma membrane

Molecular Function: interleukin-11 binding; protein binding; protein homodimerization activity; interleukin-27 receptor activity; interleukin-6 receptor binding; interleukin-6 binding; oncostatin-M receptor activity; leukemia inhibitory factor receptor activity; growth factor binding; ciliary neurotrophic factor receptor activity; interleukin-6 receptor activity; ciliary neurotrophic factor receptor binding; interleukin-11 receptor activity

Biological Process: glycogen metabolic process; viral reproduction; cytokine and chemokine mediated signaling pathway; leukemia inhibitory factor signaling pathway; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of osteoblast differentiation; positive regulation of tyrosine phosphorylation of Stat1 protein; regulation of Notch signaling pathway; positive regulation of acute inflammatory response; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of T cell proliferation; positive regulation of adaptive immune response; positive regulation of astrocyte differentiation; negative regulation of apoptosis
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Product References and Citations for anti-IL6ST antibody

   Lehmann,U., et.al., J. Biol. Chem. 278 (1), 661-671 (2003)
Novotny-Diermayr,V., et.al., J. Biol. Chem. 277 (51), 49134-49142 (2002)
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 Research Articles on IL6ST    1. Studies indicate that the interleukin-6 (IL-6)/soluble forms of the IL-6R (sIL-6R)/soluble forms of glycoprotein 130 (sgp130) system as highly dynamic and regulated signal pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL6ST antibodyPathways associated with anti-IL6ST antibody
 Reference Product  PubMed Publications
 STAT3 antibody  >290 publications with IL6ST and STAT3
 LIF antibody  >238 publications with IL6ST and LIF
 OSM antibody  >178 publications with IL6ST and OSM
 STAT1 antibody  >70 publications with IL6ST and STAT1
 JAK1 antibody  >51 publications with IL6ST and JAK1
 IL6 antibody  >47 publications with IL6ST and IL6
 JAK2 antibody  >46 publications with IL6ST and JAK2
 SOCS3 antibody  >37 publications with IL6ST and SOCS3
 PTPN11 antibody  >31 publications with IL6ST and PTPN11
 IL6R antibody  >20 publications with IL6ST and IL6R
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Diseases associated with anti-IL6ST antibodyOrgans/Tissues associated with anti-IL6ST antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >118 publications with IL6ST and Inflammation
 Carcinoma Antibodies  >62 publications with IL6ST and Carcinoma
 Nervous System Diseases Antibodies  >52 publications with IL6ST and Nervous System Diseases
 Disease Models, Animal Antibodies  >52 publications with IL6ST and Disease Models, Animal
 Heart Diseases Antibodies  >48 publications with IL6ST and Heart Diseases
 Necrosis Antibodies  >44 publications with IL6ST and Necrosis
 Liver Diseases Antibodies  >39 publications with IL6ST and Liver Diseases
 Hypertrophy Antibodies  >31 publications with IL6ST and Hypertrophy
 Arthritis, Rheumatoid Antibodies  >25 publications with IL6ST and Arthritis, Rheumatoid
 Liver Neoplasms Antibodies  >25 publications with IL6ST and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >215 publications with IL6ST and Blood
 Liver Antibodies  >89 publications with IL6ST and Liver
 Bone Antibodies  >82 publications with IL6ST and Bone
 Brain Antibodies  >80 publications with IL6ST and Brain
 Heart Antibodies  >72 publications with IL6ST and Heart
 Muscle Antibodies  >64 publications with IL6ST and Muscle
 Bone Marrow Antibodies  >57 publications with IL6ST and Bone Marrow
 Nerve Antibodies  >57 publications with IL6ST and Nerve
 Vascular Antibodies  >35 publications with IL6ST and Vascular
 Embryonic Tissue Antibodies  >34 publications with IL6ST and Embryonic Tissue
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