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anti-PDE10A antibody :: Rabbit Phospho-PDE10A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540100 anti-PDE10A antibody
Unit / Price
0.1 mg Affinity-Purified  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Phospho-PDE10A, Polyclonal Antibody

 Also Known As   

Phospho-PDE10A Antibody

 Product Synonym Names    5''-cyclic phosphodiesterase 10A; cAMP and cAMP inhibited cGMP 3'5' cyclic phosphodiesterase 10A; FLJ11894; HSPDE10A; PDE 10A; Pde10a; Phosphodiesterase 10A antibody
 Product Gene Name   

anti-PDE10A antibody

[Similar Products]
 Matching Pairs    Antibody: Phospho-PDE10A (MBS540100)
Positive Control: Phospho-PDE10A (MBS543149)
 Antibody/Peptide Pairs    Phospho-PDE10A peptide (MBS544305) is used for blocking the activity of Phospho-PDE10A antibody (MBS540100)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610652
 3D Structure    ModBase 3D Structure for Q9Y233
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Monkey, Mouse, Rat
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 Form/Format    Affinity Purified
 Concentration    0.7 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Phosphorylated synthetic MAP common to all PDE10A variants. Taken within amino acid region 1-50 on human PDE10A protein.
 Expression    Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
 Modification    Phosphorylated
 Molecular Function    Hydrolase, metal-ion binding, cGMP binding
 Structure    Homodimer
 Subcellular Location    Cytoplasm
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-PDE10A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PDE10A antibody

   Affinity Purified Phosphorylated Phosphodiesterase 10A Antibody
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.
 Product Categories/Family for anti-PDE10A antibody    Primary Antibodies; Signal Transduction; Second Messengers; cAMP; Phospho-PDE10A Antibody
 Applications Tested/Suitable for anti-PDE10A antibody   

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-PDE10A antibody    Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500
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NCBI/Uniprot data below describe general gene information for PDE10A. It may not necessarily be applicable to this product.
 NCBI GI #    4894717
 NCBI GeneID    10846
 NCBI Accession #    AAD32596.1 [Other Products]
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 UniProt Primary Accession #    Q9Y233 [Other Products]
 UniProt Secondary Accession #    Q6FHX1; Q9HCP9; Q9NTV4; Q9ULW9; Q9Y5T1 [Other Products]
 UniProt Related Accession #    Q9Y233 [Other Products]
 Molecular Weight    89,390 Da
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 NCBI Official Full Name    3',5'-cyclic nucleotide phosphodiesterase 10A2, partial
 NCBI Official Synonym Full Names    phosphodiesterase 10A
 NCBI Official Symbol    PDE10A [Similar Products]
 NCBI Official Synonym Symbols   
ADSD2; IOLOD; HSPDE10A; PDE10A19
[Similar Products]
 NCBI Protein Information    cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
 UniProt Protein Name    cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
 Protein Family    cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase
 UniProt Gene Name    PDE10A [Similar Products]
 UniProt Entry Name    PDE10_HUMAN
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 NCBI Summary for PDE10A    The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for PDE10A    PDE10A: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: cytosol; membrane; perikaryon

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP binding; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; drug binding; metal ion binding

Biological Process: cAMP catabolic process; cGMP catabolic process; signal transduction
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 Research Articles on PDE10A    1. Lu AF33241 represents a novel PDE2A/PDE10A inhibitor tool which can penetrate the blood brain barrier.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PDE10A antibodyPathways associated with anti-PDE10A antibody
 Reference Product  PubMed Publications
 ADCY5 antibody  >1 publications with PDE10A and ADCY5
 Products by Pathway  Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Nitric Oxide Stimulates Guanylate Cyclase Pathway antibodies  Nitric Oxide Stimulates Guanylate Cyclase Pathway Diagram
 Platelet Homeostasis Pathway antibodies  Platelet Homeostasis Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with anti-PDE10A antibodyOrgans/Tissues associated with anti-PDE10A antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >34 publications with PDE10A and Nervous System Diseases
 Brain Diseases Antibodies  >25 publications with PDE10A and Brain Diseases
 Disease Models, Animal Antibodies  >22 publications with PDE10A and Disease Models, Animal
 Cognition Disorders Antibodies  >20 publications with PDE10A and Cognition Disorders
 Movement Disorders Antibodies  >18 publications with PDE10A and Movement Disorders
 Memory Disorders Antibodies  >9 publications with PDE10A and Memory Disorders
 Learning Disorders Antibodies  >7 publications with PDE10A and Learning Disorders
 Neurobehavioral Manifestations Antibodies  >6 publications with PDE10A and Neurobehavioral Manifestations
 Weight Loss Antibodies  >4 publications with PDE10A and Weight Loss
 Hyperkinesis Antibodies  >3 publications with PDE10A and Hyperkinesis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >134 publications with PDE10A and Brain
 Testis Antibodies  >10 publications with PDE10A and Testis
 Pancreas Antibodies  >7 publications with PDE10A and Pancreas
 Lung Antibodies  >6 publications with PDE10A and Lung
 Thyroid Antibodies  >6 publications with PDE10A and Thyroid
 Muscle Antibodies  >4 publications with PDE10A and Muscle
 Eye Antibodies  >3 publications with PDE10A and Eye
 Kidney Antibodies  >3 publications with PDE10A and Kidney
 Intestine Antibodies  >2 publications with PDE10A and Intestine
 Pituitary Gland Antibodies  >2 publications with PDE10A and Pituitary Gland
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