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anti-Tsc2 antibody :: Rabbit Phospho-mouse TSC2 (S1343) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9211017
Dot Blot (DB)
Unit / Price
0.08 mL  /  $155 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Phospho-mouse TSC2 (S1343), Polyclonal Antibody

★Popular Item★
 Also Known As   

Phospho-mouse TSC2 (S1343) Antibody

 Product Synonym Names    Tuberin; Tuberous sclerosis 2 protein homolog; Tsc2
 Product Gene Name   

anti-Tsc2 antibody

[Similar Products]
 Antibody/Peptide Pairs    TSC2 (S1343) peptide (MBS9230793) is used for blocking the activity of TSC2 (S1343) antibody (MBS9211017)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q61037
 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Clone Number    RB41255
 Host    Rabbit
 Species Reactivity    Mouse (Predicted Reactivity: Rat)
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 Specificity    This mouse TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1343 of mouse TSC2.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Function    In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
 Cellular Location    Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
 Tissue Location    Widely expressed.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-Tsc2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Tsc2 antibody

   In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity).
 Product Categories/Family for anti-Tsc2 antibody    Cell Biology; Signal Transduction; Phospho Antibodies
 Applications Tested/Suitable for anti-Tsc2 antibody   

Dot Blot (DB), ELISA (EIA)

 Application Notes for anti-Tsc2 antibody    DB~~1:500
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 Dot Blot (DB) of anti-Tsc2 antibody    Dot blot analysis of mouse TSC2 Antibody (Phospho S1343) Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
anti-Tsc2 antibody Dot Blot (DB) image
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NCBI/Uniprot data below describe general gene information for Tsc2. It may not necessarily be applicable to this product.
 NCBI GI #    9297076
 NCBI GeneID    9297076
 NCBI Accession #    Q61037.1 [Other Products]
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 UniProt Primary Accession #    Q61037 [Other Products]
 UniProt Secondary Accession #    P97723; P97724; P97725; P97727; Q61007; Q61008; Q9WUF6 [Other Products]
 Molecular Weight    202071
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 NCBI Official Full Name    Tuberin
 UniProt Protein Name    Tuberin
 UniProt Synonym Protein Names   
Tuberous sclerosis 2 protein homolog
 Protein Family    Tuberin
 UniProt Gene Name    Tsc2 [Similar Products]
 UniProt Entry Name    TSC2_MOUSE
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 UniProt Comments for Tsc2    TSC2: a product of the tumor suppressor gene TSC2. Tuberin and Hamartin (TSC1) form a tumor suppressor heterodimer that inhibits the mTOR nutrient signaling input. TSC1/TSC2 targets the small G protein Rheb, a novel mediator of the nutrient signaling input to mTOR. Functions as a Rheb GTPase activating protein (GAP). Four alternatively spliced isoforms have been described.

Protein type: GAPs; Tumor suppressor; Nuclear receptor co-regulator; Cell cycle regulation; GAPs, misc.

Cellular Component: neuron projection; protein complex; intracellular membrane-bound organelle; cell; dendrite; caveola; cytosol; lipid raft; TSC1-TSC2 complex; cytoskeleton; growth cone; cell soma; membrane; perinuclear region of cytoplasm; cytoplasm; intracellular

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; GTPase activator activity; phosphatase binding

Biological Process: negative regulation of MAP kinase activity; phosphoinositide 3-kinase cascade; regulation of insulin receptor signaling pathway; negative regulation of Wnt receptor signaling pathway; protein heterooligomerization; regulation of cell cycle; heart development; negative regulation of insulin receptor signaling pathway; negative regulation of cell size; signal transduction; negative regulation of cell proliferation; protein localization; establishment of protein localization; cell projection organization and biogenesis; positive chemotaxis; protein import into nucleus; regulation of endocytosis; acute-phase response; protein kinase B signaling cascade; protein homooligomerization; negative regulation of epithelial cell proliferation; negative regulation of TOR signaling pathway; negative regulation of protein kinase B signaling cascade; regulation of small GTPase mediated signal transduction; insulin-like growth factor receptor signaling pathway; cellular response to insulin stimulus; glucose import; neural tube closure; response to hypoxia; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of phosphoinositide 3-kinase cascade; positive regulation of GTPase activity
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Tsc2 antibodyOrgans/Tissues associated with anti-Tsc2 antibody
 Reference Product  PubMed Publications
 Tsc1 antibody  >919 publications with Tsc2 and Tsc1
 Rheb antibody  >170 publications with Tsc2 and Rheb
 Akt1 antibody  >39 publications with Tsc2 and Akt1
 Rps6ka1 antibody  >8 publications with Tsc2 and Rps6ka1
 Akt2 antibody  >7 publications with Tsc2 and Akt2
 Akt3 antibody  >3 publications with Tsc2 and Akt3
 Prkaa2 antibody  >2 publications with Tsc2 and Prkaa2
 Prkaa1 antibody  >2 publications with Tsc2 and Prkaa1
 Ywhab antibody  >1 publications with Tsc2 and Ywhab
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >376 publications with Tsc2 and Brain
 Kidney Antibodies  >310 publications with Tsc2 and Kidney
 Other Antibodies  >302 publications with Tsc2 and Other
 Muscle Antibodies  >173 publications with Tsc2 and Muscle
 Lung Antibodies  >162 publications with Tsc2 and Lung
 Heart Antibodies  >132 publications with Tsc2 and Heart
 Skin Antibodies  >123 publications with Tsc2 and Skin
 Blood Antibodies  >112 publications with Tsc2 and Blood
 Liver Antibodies  >83 publications with Tsc2 and Liver
 Embryonic Tissue Antibodies  >34 publications with Tsc2 and Embryonic Tissue
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