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anti-PGK1 antibody :: Rabbit anti-Human, Mouse Phosphoglycerate kinase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS715259
Western Blot (WB)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Phosphoglycerate kinase 1 (PGK1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human Phosphoglycerate kinase 1 polyclonal Antibody, FITC

 Product Gene Name   

anti-PGK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    300653
 3D Structure    ModBase 3D Structure for P00558
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    FITC
 Immunogen    Recombinant human Phosphoglycerate kinase 1 protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-17943 / sc-23805 / sc-28784
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PGK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PGK1 antibody

   Also known as ATP:3-phosphoglycerate 1-phosphotransferase, this major enzyme in glycolysis catalyzes the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate, generating one molecule of ATP. In addition to its role as a glycolytic enzyme, PGK-1 appears to acts as a polymerase alpha cofactor protein. Defects in PGK1 are generally associated with chronic hemolytic anemia.
 Applications Tested/Suitable for anti-PGK1 antibody   

ELISA (EIA)

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 Western Blot (WB) of anti-PGK1 antibody    Western blot All lanes: Phosphoglycerate kinase 1 antibody at at 2 /mlLane 1: EC109 whole cell lysateLane 2: 293T whole cell lysate SecondaryGoat polyclonal to Rabbit IgG at 1/15000 dilution Predicted band size: 46kDa Observed band size: 46kDa
anti-PGK1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PGK1. It may not necessarily be applicable to this product.
 NCBI GI #    4505763
 NCBI GeneID    5230
 NCBI Accession #    NP_000282.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000291.3 [Other Products]
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 UniProt Primary Accession #    P00558 [Other Products]
 UniProt Secondary Accession #    Q5J7W1; Q6IBT6; Q8NI87; A8K4W6; B7Z7A9 [Other Products]
 UniProt Related Accession #    P00558 [Other Products]
 Molecular Weight    41,429 Da [Similar Products]
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 NCBI Official Full Name    phosphoglycerate kinase 1
 NCBI Official Synonym Full Names    phosphoglycerate kinase 1
 NCBI Official Symbol    PGK1 [Similar Products]
 NCBI Official Synonym Symbols   
PGKA; MIG10; HEL-S-68p
[Similar Products]
 NCBI Protein Information    phosphoglycerate kinase 1
 UniProt Protein Name    Phosphoglycerate kinase 1
 UniProt Synonym Protein Names   
Cell migration-inducing gene 10 protein; Primer recognition protein 2; PRP 2
 Protein Family    Phosphoglycerate kinase
 UniProt Gene Name    PGK1 [Similar Products]
 UniProt Synonym Gene Names    PGKA; PRP 2 [Similar Products]
 UniProt Entry Name    PGK1_HUMAN
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 NCBI Summary for PGK1    The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]
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 UniProt Comments for PGK1    PGK1: an apparent multifunctional protein. A glycolytic enzyme and a polymerase alpha cofactor protein (primer recognition protein).

Protein type: EC 2.7.2.3; Kinase, other; Carbohydrate Metabolism - glycolysis and gluconeogenesis

Chromosomal Location of Human Ortholog: Xq13.3

Cellular Component: cytosol; lipid raft; membrane

Molecular Function: ATP binding; phosphoglycerate kinase activity; protein binding

Biological Process: carbohydrate metabolic process; epithelial cell differentiation; gluconeogenesis; glucose metabolic process; phosphorylation

Disease: Phosphoglycerate Kinase 1 Deficiency
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 Research Articles on PGK1    1. mutations associated with hPGK1 deficiency lead to increased aggregation and proteolysis rates in vitro and inside cells due to protein thermodynamic destabilization
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PGK1 antibodyPathways associated with anti-PGK1 antibody
 Reference Product  PubMed Publications
 GAPDH antibody  >53 publications with PGK1 and GAPDH
 ENO1 antibody  >15 publications with PGK1 and ENO1
 TPI1 antibody  >9 publications with PGK1 and TPI1
 GPI antibody  >6 publications with PGK1 and GPI
 ENO2 antibody  >5 publications with PGK1 and ENO2
 PKLR antibody  >2 publications with PGK1 and PKLR
 Products by Pathway  Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Gluconeogenesis Pathway antibodies  Gluconeogenesis Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
 Glycolysis Pathway antibodies  Glycolysis Pathway Diagram
 Glycolysis (Embden-Meyerhof Pathway), Glucose => Pyruvate antibodies  Glycolysis (Embden-Meyerhof Pathway), Glucose => Pyruvate Diagram
Diseases associated with anti-PGK1 antibodyOrgans/Tissues associated with anti-PGK1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >37 publications with PGK1 and Nervous System Diseases
 Brain Diseases Antibodies  >24 publications with PGK1 and Brain Diseases
 Anemia Antibodies  >18 publications with PGK1 and Anemia
 Inflammation Antibodies  >12 publications with PGK1 and Inflammation
 Liver Diseases Antibodies  >11 publications with PGK1 and Liver Diseases
 Breast Neoplasms Antibodies  >11 publications with PGK1 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >11 publications with PGK1 and Neoplasms, Experimental
 Death Antibodies  >9 publications with PGK1 and Death
 Liver Neoplasms Antibodies  >9 publications with PGK1 and Liver Neoplasms
 Lung Neoplasms Antibodies  >8 publications with PGK1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >45 publications with PGK1 and Blood
 Brain Antibodies  >31 publications with PGK1 and Brain
 Liver Antibodies  >26 publications with PGK1 and Liver
 Lung Antibodies  >17 publications with PGK1 and Lung
 Bone Antibodies  >17 publications with PGK1 and Bone
 Muscle Antibodies  >17 publications with PGK1 and Muscle
 Vascular Antibodies  >15 publications with PGK1 and Vascular
 Skin Antibodies  >13 publications with PGK1 and Skin
 Prostate Antibodies  >12 publications with PGK1 and Prostate
 Kidney Antibodies  >11 publications with PGK1 and Kidney
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