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| Product Name
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Phosphoinositide 3 Kinase, p110 beta (PIK3CB), Polyclonal Antibody
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| Also Known As
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Phosphoinositide 3 Kinase, p110 beta (DKFZp779K1237, MGC133043, p110beta, Phosphatidylinositol 3 Kinase Catalytic beta Polypeptide, Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit beta Isoform, Phosphoinositide 3 Kinase Catalytic beta Pol
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| Product Synonym Names
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Anti -Phosphoinositide 3 Kinase, p110 beta (DKFZp779K1237, MGC133043, p110beta, Phosphatidylinositol 3 Kinase Catalytic beta Polypeptide, Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit beta Isoform, Phosphoinositide 3 Kinase Catalytic beta Pol
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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| Chromosome Location
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Chromosome: 3; NC_000003.11 (138374231..138478185, complement). Location: 3q22.3
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| OMIM
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602925
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| 3D Structure
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ModBase 3D Structure for P42338
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| Clonality
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Polyclonal
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| Isotype
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IgG
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| Host
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Rabbit
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| Species Reactivity
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Human
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| Specificity
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Recognizes the internal domain of human PI3 Kinase, p110 beta. Species Sequence Homology: Monkey, canine, Rat and Mouse.
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| Purity/Purification
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Affinity Purified
Purified by immunoaffinity chromatography.
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| Form/Format
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Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
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| Immunogen
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Synthetic linear peptide corresponding to the internal domain of PI3 Kinase, p110 beta (KLH).
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| Positive Control
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HEK-293 cell lysate
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| Preparation and Storage
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May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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| Other Notes
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Small volumes of anti-PIK3CB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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PI3 Kinase (Phosphatidylinositol 3-Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival, signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85kD regulatory subunit and a 110kD catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospholipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the beta:gamma subunits of heterotrimeric G-proteins. PI3 Kinase is inhibitable by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway.
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| Product Categories/Family for anti-PIK3CB antibody
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Antibodies; Abs to Protein Kinases
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| Applications Tested/Suitable for anti-PIK3CB antibody
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ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
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| Application Notes for anti-PIK3CB antibody
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Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry.
Dilution: ELISA: 0.5ng/well
Western Blot: 0.05-0.1ug/ml
Immunocytochemistry: 1:100
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| NCBI/Uniprot data below describe general gene information for PIK3CB. It may not necessarily be applicable to this product. |
| NCBI GI #
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455760
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| NCBI GeneID
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5291
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| UniProt Primary Accession #
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P42338
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[Other Products]
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| UniProt Secondary Accession #
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Q24JU2; D3DNF0
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[Other Products]
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| UniProt Related Accession #
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P42338; Q68DL0; Q6PJ60; Q9BTS4
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[Other Products]
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| Molecular Weight
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122,762 Da
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[Similar Products]
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| NCBI Official Full Name
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phosphatidylinositol 3-kinase p110 beta isoform
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| NCBI Official Synonym Full Names
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phosphoinositide-3-kinase, catalytic, beta polypeptide
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| NCBI Official Symbol
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PIK3CB
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[Similar Products]
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| NCBI Official Synonym Symbols
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PI3K; PIK3C1; P110BETA; PI3KBETA; MGC133043; DKFZp779K1237
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[Similar Products]
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| NCBI Protein Information
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phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; PI3K-beta; OTTHUMP00000216901; OTTHUMP00000216904; PtdIns-3-kinase p110; PI3-kinase subunit beta; PI3-kinase p110 subunit beta; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta
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| UniProt Protein Name
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Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform
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| UniProt Synonym Protein Names
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Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta
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| Protein Family
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Phosphatidylinositol 4,5-bisphosphate 3-kinase
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| UniProt Gene Name
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PIK3CB
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[Similar Products]
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| UniProt Synonym Gene Names
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PIK3C1
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[Similar Products]
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| UniProt Entry Name
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PK3CB_HUMAN
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| NCBI Summary for PIK3CB
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Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993 [PubMed 8246984]).[supplied by OMIM]
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| UniProt Comments for PIK3CB
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PIK3CB: catalytic subunit of phosphoinositide-3-kinase beta. Catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration and cell survival. PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. Expressed ubiquitously.
Protein type: Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; EC 2.7.1.153; Kinase, lipid
Chromosomal Location of Human Ortholog: 3q22.3
Cellular Component: plasma membrane; cytosol; phosphoinositide 3-kinase complex; nucleus
Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; insulin receptor substrate binding; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; phosphoinositide 3-kinase activity; ATP binding
Biological Process: phosphoinositide 3-kinase cascade; nerve growth factor receptor signaling pathway; regulation of cell-matrix adhesion; activation of MAPK activity; chemotaxis; signal transduction; T cell receptor signaling pathway; embryonic cleavage; phosphoinositide phosphorylation; phospholipid metabolic process; positive regulation of autophagy; epidermal growth factor receptor signaling pathway; platelet activation; cell migration; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; phosphatidylinositol biosynthetic process; insulin receptor signaling pathway; autophagy; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; homophilic cell adhesion; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway
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| Research Articles on PIK3CB
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1. study shows that p110beta nuclear localization signal and p85beta nuclear export sequence regulate p85beta/p110beta nuclear localization, supporting the idea that nuclear, but not cytoplasmic, p110beta controls cell survival
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with anti-PIK3CB antibody | Pathways associated with anti-PIK3CB antibody |
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| Diseases associated with anti-PIK3CB antibody | Organs/Tissues associated with anti-PIK3CB antibody |
| Disease Name |
Pubmed Publications |
| Neoplasms Antibodies |
>72 publications with PIK3CB and Neoplasms |
| Inflammation Antibodies |
>21 publications with PIK3CB and Inflammation |
| Metabolic Diseases Antibodies |
>16 publications with PIK3CB and Metabolic Diseases |
| Cell Transformation, Neoplastic Antibodies |
>15 publications with PIK3CB and Cell Transformation, Neoplastic |
| Leukemia Antibodies |
>14 publications with PIK3CB and Leukemia |
| Breast Neoplasms Antibodies |
>13 publications with PIK3CB and Breast Neoplasms |
| Asthma Antibodies |
>10 publications with PIK3CB and Asthma |
| Leukemia, Myeloid Antibodies |
>10 publications with PIK3CB and Leukemia, Myeloid |
| Neoplasms, Experimental Antibodies |
>10 publications with PIK3CB and Neoplasms, Experimental |
| Leukemia, Myeloid, Acute Antibodies |
>9 publications with PIK3CB and Leukemia, Myeloid, Acute |
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Antibody 
