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anti-PIK3CB antibody :: Rabbit anti-Human Phosphoinositide 3 Kinase, p110 beta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS620204 anti-PIK3CB antibody
Unit / Price
0.1 mL  /  $600 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Phosphoinositide 3 Kinase, p110 beta (PIK3CB), Polyclonal Antibody

 Also Known As   

Phosphoinositide 3 Kinase, p110 beta (DKFZp779K1237, MGC133043, p110beta, Phosphatidylinositol 3 Kinase Catalytic beta Polypeptide, Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit beta Isoform, Phosphoinositide 3 Kinase Catalytic beta Pol

 Product Synonym Names    Anti -Phosphoinositide 3 Kinase, p110 beta (DKFZp779K1237, MGC133043, p110beta, Phosphatidylinositol 3 Kinase Catalytic beta Polypeptide, Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit beta Isoform, Phosphoinositide 3 Kinase Catalytic beta Pol
 Product Gene Name   

anti-PIK3CB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (138374231..138478185, complement). Location: 3q22.3
 OMIM    602925
 3D Structure    ModBase 3D Structure for P42338
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes the internal domain of human PI3 Kinase, p110 beta. Species Sequence Homology: Monkey, canine, Rat and Mouse.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
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 Immunogen    Synthetic linear peptide corresponding to the internal domain of PI3 Kinase, p110 beta (KLH).
 Positive Control    HEK-293 cell lysate
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-PIK3CB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PIK3CB antibody

   PI3 Kinase (Phosphatidylinositol 3-Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival, signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85kD regulatory subunit and a 110kD catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospholipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the beta:gamma subunits of heterotrimeric G-proteins. PI3 Kinase is inhibitable by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway.
 Product Categories/Family for anti-PIK3CB antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-PIK3CB antibody   

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

 Application Notes for anti-PIK3CB antibody    Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry.
Dilution: ELISA: 0.5ng/well
Western Blot: 0.05-0.1ug/ml
Immunocytochemistry: 1:100
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NCBI/Uniprot data below describe general gene information for PIK3CB. It may not necessarily be applicable to this product.
 NCBI GI #    455760
 NCBI GeneID    5291
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 UniProt Primary Accession #    P42338 [Other Products]
 UniProt Secondary Accession #    Q24JU2; D3DNF0 [Other Products]
 UniProt Related Accession #    P42338; Q68DL0; Q6PJ60; Q9BTS4 [Other Products]
 Molecular Weight    122,762 Da [Similar Products]
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 NCBI Official Full Name    phosphatidylinositol 3-kinase p110 beta isoform
 NCBI Official Synonym Full Names    phosphoinositide-3-kinase, catalytic, beta polypeptide
 NCBI Official Symbol    PIK3CB [Similar Products]
 NCBI Official Synonym Symbols   
PI3K; PIK3C1; P110BETA; PI3KBETA; MGC133043; DKFZp779K1237
[Similar Products]
 NCBI Protein Information    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; PI3K-beta; OTTHUMP00000216901; OTTHUMP00000216904; PtdIns-3-kinase p110; PI3-kinase subunit beta; PI3-kinase p110 subunit beta; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta
 UniProt Protein Name    Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform
 UniProt Synonym Protein Names   
Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta
 Protein Family    Phosphatidylinositol 4,5-bisphosphate 3-kinase
 UniProt Gene Name    PIK3CB [Similar Products]
 UniProt Synonym Gene Names    PIK3C1 [Similar Products]
 UniProt Entry Name    PK3CB_HUMAN
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 NCBI Summary for PIK3CB    Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993 [PubMed 8246984]).[supplied by OMIM]
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 UniProt Comments for PIK3CB    PIK3CB: catalytic subunit of phosphoinositide-3-kinase beta. Catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration and cell survival. PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. Expressed ubiquitously.

Protein type: Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; EC 2.7.1.153; Kinase, lipid

Chromosomal Location of Human Ortholog: 3q22.3

Cellular Component: plasma membrane; cytosol; phosphoinositide 3-kinase complex; nucleus

Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; insulin receptor substrate binding; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; phosphoinositide 3-kinase activity; ATP binding

Biological Process: phosphoinositide 3-kinase cascade; nerve growth factor receptor signaling pathway; regulation of cell-matrix adhesion; activation of MAPK activity; chemotaxis; signal transduction; T cell receptor signaling pathway; embryonic cleavage; phosphoinositide phosphorylation; phospholipid metabolic process; positive regulation of autophagy; epidermal growth factor receptor signaling pathway; platelet activation; cell migration; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; phosphatidylinositol biosynthetic process; insulin receptor signaling pathway; autophagy; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; homophilic cell adhesion; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on PIK3CB    1. study shows that p110beta nuclear localization signal and p85beta nuclear export sequence regulate p85beta/p110beta nuclear localization, supporting the idea that nuclear, but not cytoplasmic, p110beta controls cell survival
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PIK3CB antibodyPathways associated with anti-PIK3CB antibody
 Reference Product  PubMed Publications
 PIK3R1 antibody  >9 publications with PIK3CB and PIK3R1
 PRKCD antibody  >2 publications with PIK3CB and PRKCD
 Products by Pathway  Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
Diseases associated with anti-PIK3CB antibodyOrgans/Tissues associated with anti-PIK3CB antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >72 publications with PIK3CB and Neoplasms
 Inflammation Antibodies  >21 publications with PIK3CB and Inflammation
 Metabolic Diseases Antibodies  >16 publications with PIK3CB and Metabolic Diseases
 Cell Transformation, Neoplastic Antibodies  >15 publications with PIK3CB and Cell Transformation, Neoplastic
 Leukemia Antibodies  >14 publications with PIK3CB and Leukemia
 Breast Neoplasms Antibodies  >13 publications with PIK3CB and Breast Neoplasms
 Asthma Antibodies  >10 publications with PIK3CB and Asthma
 Leukemia, Myeloid Antibodies  >10 publications with PIK3CB and Leukemia, Myeloid
 Neoplasms, Experimental Antibodies  >10 publications with PIK3CB and Neoplasms, Experimental
 Leukemia, Myeloid, Acute Antibodies  >9 publications with PIK3CB and Leukemia, Myeloid, Acute
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >81 publications with PIK3CB and Blood
 Muscle Antibodies  >28 publications with PIK3CB and Muscle
 Vascular Antibodies  >20 publications with PIK3CB and Vascular
 Lung Antibodies  >13 publications with PIK3CB and Lung
 Liver Antibodies  >12 publications with PIK3CB and Liver
 Bone Antibodies  >11 publications with PIK3CB and Bone
 Bone Marrow Antibodies  >10 publications with PIK3CB and Bone Marrow
 Brain Antibodies  >10 publications with PIK3CB and Brain
 Prostate Antibodies  >6 publications with PIK3CB and Prostate
 Skin Antibodies  >5 publications with PIK3CB and Skin
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