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anti-PLA2G4A antibody :: Rabbit Phospholipase A2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS176121
Western Blot (WB)
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Phospholipase A2 (PLA2G4A), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Phospholipase A2 antibody

 Product Synonym Names    Cytosolic phospholipase A2; phospholipase A2, group IVA(cytosolic, calcium-dependent); Calcium dependent phospholipid binding protein antibody; CPLA 2 antibody; cPLA2 alpha antibody; cPLA2 antibody; Cytosolic phospholipase A2 antibody; Cytosolic phospholipase A2 group IVA antibody; Lysophospholipase antibody; MGC126350 antibody; PA24A_HUMAN antibody; Phosphatidylcholine 2 acylhydrolase antibody; Phosphatidylcholine 2-acylhydrolase antibody; Phospholipase A2 group 4 A antibody; Phospholipase A2 group IVA(cytosolic calcium dependent) antibody; Phospholipase A2 group IVA antibody; PhospholipaseA2 antibody; PLA2G4 antibody; pla2g4a antibody
 Product Gene Name   

anti-PLA2G4A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600522
 3D Structure    ModBase 3D Structure for P47712
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human Phospholipase A2 (686-700aa PNQAFKRLHDLMHFN), different from the related rat and mouse sequences by one amino acid.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PLA2G4A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PLA2G4A antibody

   Description: Rabbit IgG polyclonal antibody for Cytosolic phospholipase A2(PLA2G4A) detection. Tested with WB in Human, Mouse, Rat.
Background: PLA2G4A(Phospholipase A2, Group IVA), is an enzyme that in humans is encoded by the PLA2G4A gene. Tay et al.(1995) mapped the PLA2G4A gene to rat chromosome 13 by PCR-based intercross genotyping and to human 1q25 by fluorescence in situ hybridization. By site-directed mutagenesis and biochemical analysis of the recombinant protein, Sharp et al.(1994) determined that ser228 participates in the catalytic mechanism of cPLA2 and that both the phospholipase A2 and the lysophospholipase activities are catalyzed by the same active site residue(s). PLA2G4A, the cytosolic phospholipase A2, appears to subserve transmembrane signaling responses to extracellular ligands(Skorecki, 1995).
 Applications Tested/Suitable for anti-PLA2G4A antibody   

Western Blot (WB)

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 Western Blot (WB) of anti-PLA2G4A antibody    Anti-PLA2G4A antibody, MBS176121, Western blotting
Lane 1: Rat Testis Tissue Lysate
Lane 2: Rat Brain Tissue Lysate
Lane 3: A549 Cell Lysate
Lane 4: COLO320 Cell Lysate

anti-PLA2G4A antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PLA2G4A. It may not necessarily be applicable to this product.
 NCBI GI #    317373312
 NCBI GeneID    5321
 NCBI Accession #    P47712.2 [Other Products]
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 UniProt Primary Accession #    P47712 [Other Products]
 UniProt Secondary Accession #    Q29R80; B1AKG4 [Other Products]
 UniProt Related Accession #    P47712 [Other Products]
 Molecular Weight    85,239 Da
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 NCBI Official Full Name    Cytosolic phospholipase A2
 NCBI Official Synonym Full Names    phospholipase A2, group IVA (cytosolic, calcium-dependent)
 NCBI Official Symbol    PLA2G4A [Similar Products]
 NCBI Official Synonym Symbols   
PLA2G4; cPLA2-alpha
[Similar Products]
 NCBI Protein Information    cytosolic phospholipase A2; cPLA2; lysophospholipase; phospholipase A2 group IVA; phosphatidylcholine 2-acylhydrolase; calcium-dependent phospholipid-binding protein
 UniProt Protein Name    Cytosolic phospholipase A2
 UniProt Synonym Protein Names   
Phospholipase A2 group IVAIncluding the following 2 domains:Phospholipase A2 (EC:3.1.1.4)Alternative name(s):Phosphatidylcholine 2-acylhydrolase
 Protein Family    Phospholipase
 UniProt Gene Name    PLA2G4A [Similar Products]
 UniProt Synonym Gene Names    CPLA2; PLA2G4; cPLA2 [Similar Products]
 UniProt Entry Name    PA24A_HUMAN
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 NCBI Summary for PLA2G4A    This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PLA2G4A    cPLA2: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Arachidonic acid is a precursor for the eicosanoids that are involved in hemodynamic regulation, inflammatory responses, and other cellular processes. Promotes cerebellar long-term depression and motor learning. Translocates to the Golgi and endoplasmic reticulum in a calcium-dependent fashion. Translocation and activation of at the ER facilitates the process of ER stress. Regulates the biogenesis of lipid droplets, a process dependent on JNK and ceramide kinase. Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca2+. The N-terminal C2 domain, by its association with lipid membranes, mediates the regulation of CPLA2 by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Inhibited when in trimolecular complex with ANXA2 and S100A10. Phosphorylation of S727 relieves this inhibitory interaction, thus activating PLA2G4A.

Protein type: Lipid Metabolism - linoleic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; EC 3.1.1.4; Lipid Metabolism - alpha-linolenic acid; Phospholipase; EC 3.1.1.5; Lipid Metabolism - arachidonic acid

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; mitochondrial inner membrane; cytoplasmic membrane-bound vesicle; cytoplasm; cytosol

Molecular Function: phospholipase A2 activity; calcium-dependent phospholipase A2 activity; calcium-dependent phospholipid binding; calcium ion binding; lysophospholipase activity

Biological Process: icosanoid biosynthetic process; platelet activating factor biosynthetic process; platelet activation; phospholipid catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; icosanoid metabolic process; arachidonic acid metabolic process; phosphatidic acid biosynthetic process; arachidonic acid secretion; blood coagulation; regulation of cell proliferation
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 Research Articles on PLA2G4A    1. cPLA2alpha appears to be an important regulator of central effectors of inflammation and joint destruction, namely MMP3, IL8, COX2, and PGE2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLA2G4A antibodyPathways associated with anti-PLA2G4A antibody
 Reference Product  PubMed Publications
 PTGS2 antibody  >304 publications with PLA2G4A and PTGS2
 PLA2G6 antibody  >106 publications with PLA2G4A and PLA2G6
 PTGS1 antibody  >95 publications with PLA2G4A and PTGS1
 ALOX5 antibody  >61 publications with PLA2G4A and ALOX5
 SYK antibody  >8 publications with PLA2G4A and SYK
 PLD2 antibody  >4 publications with PLA2G4A and PLD2
 KAT5 antibody  >2 publications with PLA2G4A and KAT5
 MKNK1 antibody  >1 publications with PLA2G4A and MKNK1
 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 1 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 1 Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Acyl Chain Remodeling Of CL Pathway antibodies  Acyl Chain Remodeling Of CL Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PE Pathway antibodies  Acyl Chain Remodelling Of PE Pathway Diagram
 Acyl Chain Remodelling Of PG Pathway antibodies  Acyl Chain Remodelling Of PG Pathway Diagram
 Acyl Chain Remodelling Of PI Pathway antibodies  Acyl Chain Remodelling Of PI Pathway Diagram
 Acyl Chain Remodelling Of PS Pathway antibodies  Acyl Chain Remodelling Of PS Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
Diseases associated with anti-PLA2G4A antibodyOrgans/Tissues associated with anti-PLA2G4A antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >308 publications with PLA2G4A and Inflammation
 Necrosis Antibodies  >174 publications with PLA2G4A and Necrosis
 Nervous System Diseases Antibodies  >143 publications with PLA2G4A and Nervous System Diseases
 Disease Models, Animal Antibodies  >119 publications with PLA2G4A and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >109 publications with PLA2G4A and Cardiovascular Diseases
 Edema Antibodies  >34 publications with PLA2G4A and Edema
 Lung Neoplasms Antibodies  >33 publications with PLA2G4A and Lung Neoplasms
 Heart Diseases Antibodies  >33 publications with PLA2G4A and Heart Diseases
 Neoplasms, Experimental Antibodies  >31 publications with PLA2G4A and Neoplasms, Experimental
 Liver Diseases Antibodies  >28 publications with PLA2G4A and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >280 publications with PLA2G4A and Brain
 Vascular Antibodies  >215 publications with PLA2G4A and Vascular
 Lung Antibodies  >198 publications with PLA2G4A and Lung
 Kidney Antibodies  >145 publications with PLA2G4A and Kidney
 Embryonic Tissue Antibodies  >64 publications with PLA2G4A and Embryonic Tissue
 Ovary Antibodies  >46 publications with PLA2G4A and Ovary
 Eye Antibodies  >44 publications with PLA2G4A and Eye
 Uterus Antibodies  >41 publications with PLA2G4A and Uterus
 Intestine Antibodies  >36 publications with PLA2G4A and Intestine
 Skin Antibodies  >36 publications with PLA2G4A and Skin
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