NP_057289.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
platelet-derived growth factor C
NCBI Official Synonym Full Names
platelet derived growth factor C
NCBI Protein Information
platelet-derived growth factor C; PDGF-C; VEGF-E; spinal cord-derived growth factor; secretory growth factor-like protein
UniProt Protein Name
Platelet-derived growth factor C
UniProt Synonym Protein Names
Fallotein; Spinal cord-derived growth factor; SCDGF; VEGF-E
UniProt Synonym Gene Names
UniProt Entry Name
PDGFC_HUMAN
NCBI Summary for PDGFC
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
UniProt Comments for PDGFC
PDGFC: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q32
Cellular Component: Golgi membrane; extracellular space; cell surface; endoplasmic reticulum lumen; cytoplasm; extracellular region; plasma membrane; nucleus
Molecular Function: protein binding; protein homodimerization activity; growth factor activity; platelet-derived growth factor receptor binding
Biological Process: positive regulation of fibroblast proliferation; embryonic development; organ morphogenesis; central nervous system development; transmembrane receptor protein tyrosine kinase activation (dimerization); positive regulation of cell division; platelet-derived growth factor receptor signaling pathway; regulation of peptidyl-tyrosine phosphorylation; positive regulation of DNA replication
Research Articles on PDGFC
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Products associated with anti-PDGFC antibody
Pathways associated with anti-PDGFC antibody
Diseases associated with anti-PDGFC antibody
Organs/Tissues associated with anti-PDGFC antibody
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