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anti-PLEC antibody :: Guinea Pig anti-Fish Plectin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS834370 anti-PLEC antibody
Unit / Price
0.1 mL  /  $475 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Plectin, Polyclonal Antibody

 Also Known As   

Plectin antibody

 Product Synonym Names    Polyclonal Plectin; Anti Plectin; PLEC1; PLTN; PLEC1b; HD1; PCN; EBS1
 Product Gene Name   

anti-PLEC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    131950
 3D Structure    ModBase 3D Structure for Q15149
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 Clonality    Polyclonal
 Host    Guinea Pig
 Species Reactivity    Fish
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 Specificity    Human Plectin C-terminal
 Form/Format    Supplied in liquid form. Contains 0.09% sodium azide
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 Biological Significance    Plectin is a giant protein (c500 kDa) found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments. In addition plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells.
 Immunogen    Plectin antibody was raised in Guinea Pig using C-terminal "C" domain of recombinant human Plectin as the immunogen.
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 Preparation and Storage    Store at 2-8 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-PLEC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PLEC antibody

   Guinea Pig polyclonal Plectin antibody
 Product Categories/Family for anti-PLEC antibody    Cell Biology
 Applications Tested/Suitable for anti-PLEC antibody   

Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-PLEC antibody    IHC: 1:500
WB: 1:16,000
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NCBI/Uniprot data below describe general gene information for PLEC. It may not necessarily be applicable to this product.
 NCBI GI #    1296662
 NCBI GeneID    5339
 NCBI Accession #    CAA91196.1 [Other Products]
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 UniProt Primary Accession #    Q15149 [Other Products]
 UniProt Secondary Accession #    Q15148; Q16640; Q6S376; Q6S377; Q6S378; Q6S379; Q6S380; Q6S381; Q6S382; Q6S383 [Other Products]
 UniProt Related Accession #    Q15149 [Other Products]
 Molecular Weight    514,775 Da [Similar Products]
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 NCBI Official Full Name    plectin
 NCBI Official Synonym Full Names    plectin
 NCBI Official Symbol    PLEC [Similar Products]
 NCBI Official Synonym Symbols   
HD1; PCN; EBS1; EBSO; PLTN; PLEC1; LGMD2Q; PLEC1b
[Similar Products]
 NCBI Protein Information    plectin
 UniProt Protein Name    Plectin
 UniProt Synonym Protein Names   
Hemidesmosomal protein 1; HD1; Plectin-1
 Protein Family    Plectin
 UniProt Gene Name    PLEC [Similar Products]
 UniProt Synonym Gene Names    PLEC1; PCN; PLTN; HD1 [Similar Products]
 UniProt Entry Name    PLEC_HUMAN
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 NCBI Summary for PLEC    Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal protein 1" or "plectin 1, intermediate filament binding 500kDa". These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011]
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 UniProt Comments for PLEC    Plectin-1: a major cytoskeleton crosslinking protein that binds to actin, intermediate filaments and microtubules. A scaffold for proteins involved in cellular signaling. Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics. Regulates the organization of keratin intermediate filaments (IF) and MAPK signaling during cell migration. Downregulates PKC signaling by sequestering RACK1. Redistributes to the uropod associated with vimentin and fodrin during polarization of peripheral blood T lymphocytes. This vimentin-plectin-fodrin complex provides a continuous linkage from the nucleus (lamin B) to the cortical cytoskeleton. Defects in PLEC1 are the cause of epidermolysis bullosa simplex 1 (EBS1). Three alternatively spliced isoforms have been described.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: intermediate filament cytoskeleton; focal adhesion; costamere; hemidesmosome; cytoplasm; plasma membrane; sarcoplasm; cytosol; sarcolemma

Molecular Function: protein binding; structural constituent of muscle; ankyrin binding; actin binding

Biological Process: extracellular matrix organization and biogenesis; hemidesmosome assembly; apoptosis; cell structure disassembly during apoptosis
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 Research Articles on PLEC    1. plectin interacts with keratins 5 and 14 in a process associated with epidermolysis bullosa simplex
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PLEC antibodyDiseases associated with anti-PLEC antibody
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >14 publications with PLEC and Immune System Diseases
 Epidermolysis Bullosa Simplex With Pyloric Atresia Antibodies  >12 publications with PLEC and Epidermolysis Bullosa Simplex With Pyloric Atresia
 Brain Diseases Antibodies  >5 publications with PLEC and Brain Diseases
 Heart Diseases Antibodies  >4 publications with PLEC and Heart Diseases
 Cardiovascular Diseases Antibodies  >4 publications with PLEC and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >2 publications with PLEC and Liver Neoplasms
 Inflammation Antibodies  >2 publications with PLEC and Inflammation
 Premature Birth Antibodies  >2 publications with PLEC and Premature Birth
 Liver Diseases Antibodies  >2 publications with PLEC and Liver Diseases
 Kidney Diseases Antibodies  >2 publications with PLEC and Kidney Diseases
Organs/Tissues associated with anti-PLEC antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >76 publications with PLEC and Skin
 Muscle Antibodies  >68 publications with PLEC and Muscle
 Nerve Antibodies  >37 publications with PLEC and Nerve
 Blood Antibodies  >18 publications with PLEC and Blood
 Heart Antibodies  >16 publications with PLEC and Heart
 Brain Antibodies  >15 publications with PLEC and Brain
 Kidney Antibodies  >10 publications with PLEC and Kidney
 Vascular Antibodies  >8 publications with PLEC and Vascular
 Liver Antibodies  >8 publications with PLEC and Liver
 Embryonic Tissue Antibodies  >8 publications with PLEC and Embryonic Tissue
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