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anti-PLXNA1 antibody :: Rabbit Plexin A1 (Sema Domain) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS472054
Testing Data
Unit / Price
0.1 mL  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Plexin A1 (Sema Domain) (PLXNA1), Polyclonal Antibody

 Also Known As   

Anti-Plexin-A1 (Sema Domain)

 Product Synonym Names    Plexin A1 (Sema Domain); PLXN1; NOV
 Product Gene Name   

anti-PLXNA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (126707437..126756235). Location: 3q21.3
 OMIM    601055
 3D Structure    ModBase 3D Structure for Q6ZTY7
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Rat, Mouse
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 Specificity    The antibody detects a 220 kDa* protein corresponding to the apparent molecular mass of Plexin-A1 on SDS-PAGE immunoblots of neonatal rat brain lysates and Cos-7 cells transfected with mouse Plexin-A1.
 Purity/Purification    Affinity Purified
 Form/Format    Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
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 Immunogen    Plexin-A1 synthetic peptide (coupled to carrier protein) corresponding to a region within the semaphorin domain in human Plexin-A1. This sequence is highly conserved in rat and mouse Plexin-A1, and has low homology to other Plexin family members.
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 Preparation and Storage    Store at -20 degree C. Do not aliquot. Stable for 1 year.
 Other Notes    Small volumes of anti-PLXNA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PLXNA1 antibody

   Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contains a semaphorin domain, multiple glycine-rich motifs, and MET-related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin-A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin-mediated activation of Plexin-A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin-A1. The expression of Plexin-A1, along with the co-receptor Neuropilin-1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A-containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin-A1 and Neuropilin-1, may have significant roles in axon regeneration after neuronal injury.
 Applications Tested/Suitable for anti-PLXNA1 antibody   

ELISA, Western Blot, Immunocytochemistry, Immunoprecipitation

 Application Notes for anti-PLXNA1 antibody    ELISA: 1:2000
Immunocytochemistry: 1:100
Immunoprecipitation: 5-10ml
Western Blot: 1:1000
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 Testing Data of anti-PLXNA1 antibody    anti-PLXNA1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for PLXNA1. It may not necessarily be applicable to this product.
 NCBI GI #    49355818
 NCBI GeneID    5361
 NCBI Accession #    NP_115618.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_032242.2 [Other Products]
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 UniProt Primary Accession #    Q6ZTY7 [Other Products]
 UniProt Related Accession #    Q6ZTY7; Q9NSM6; Q9UIW2 [Other Products]
 Molecular Weight    208419 Da [Similar Products]
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 NCBI Official Full Name    plexin A1
 NCBI Official Synonym Full Names    plexin A1
 NCBI Official Symbol    PLXNA1 [Similar Products]
 NCBI Official Synonym Symbols   
NOV; NOVP; PLXN1; PLEXIN-A1; DKFZp761P19121
[Similar Products]
 NCBI Protein Information    plexin-A1; plexin 1; OTTHUMP00000215966; semaphorin receptor NOV
 UniProt Protein Name    cDNA FLJ44113 fis, clone TESTI4046487, highly similar to Mus musculus plexin A1 (Plxna1)
 Protein Family    Plexin
 UniProt Entry Name    Q6ZTY7_HUMAN
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 UniProt Comments for PLXNA1    PLXNA1: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Detected in fetal brain, lung, liver and kidney. Belongs to the plexin family.

Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: cytoplasm; plasma membrane; integral to membrane; nucleus

Molecular Function: semaphorin receptor activity; receptor activity

Biological Process: axon guidance; regulation of smooth muscle cell migration; multicellular organismal development
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Product References and Citations for anti-PLXNA1 antibody

   • Takahashi, T. & Strittmatter, S.M. (2001) Neuron 29:429.
• Tamagnone, L. et al. (1999) Cell 99:71.
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 Research Articles on PLXNA1    1. Expression of Plexin A1 in gastric carcinoma was significantly higher than that in normal gastric mucosa.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLXNA1 antibodyPathways associated with anti-PLXNA1 antibody
 Reference Product  PubMed Publications
 PLXNB1 antibody  >10 publications with PLXNA1 and PLXNB1
 SEMA6D antibody  >9 publications with PLXNA1 and SEMA6D
 NRP1 antibody  >4 publications with PLXNA1 and NRP1
 RND1 antibody  >2 publications with PLXNA1 and RND1
 FES antibody  >2 publications with PLXNA1 and FES
 RHOD antibody  >1 publications with PLXNA1 and RHOD
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CRMPs In Sema3A Signaling Pathway antibodies  CRMPs In Sema3A Signaling Pathway Diagram
 Other Semaphorin Interactions Pathway antibodies  Other Semaphorin Interactions Pathway Diagram
 SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway antibodies  SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway Diagram
 Sema3A PAK Dependent Axon Repulsion Pathway antibodies  Sema3A PAK Dependent Axon Repulsion Pathway Diagram
 Sema3A PAK Dependent Axon Repulsion Pathway antibodies  Sema3A PAK Dependent Axon Repulsion Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram
Diseases associated with anti-PLXNA1 antibodyOrgans/Tissues associated with anti-PLXNA1 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >1 publications with PLXNA1 and Kidney Diseases
 Adenoma Antibodies  >1 publications with PLXNA1 and Adenoma
 Neurodegenerative Diseases Antibodies  >1 publications with PLXNA1 and Neurodegenerative Diseases
 Kidney Neoplasms Antibodies  >1 publications with PLXNA1 and Kidney Neoplasms
 Diabetes Mellitus Antibodies  >1 publications with PLXNA1 and Diabetes Mellitus
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with PLXNA1 and Brain
 Embryonic Tissue Antibodies  >14 publications with PLXNA1 and Embryonic Tissue
 Blood Antibodies  >10 publications with PLXNA1 and Blood
 Vascular Antibodies  >9 publications with PLXNA1 and Vascular
 Eye Antibodies  >5 publications with PLXNA1 and Eye
 Kidney Antibodies  >5 publications with PLXNA1 and Kidney
 Heart Antibodies  >4 publications with PLXNA1 and Heart
 Bone Antibodies  >3 publications with PLXNA1 and Bone
 Lung Antibodies  >3 publications with PLXNA1 and Lung
 Skin Antibodies  >2 publications with PLXNA1 and Skin
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