P51805
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
plexin A3
NCBI Official Synonym Full Names
plexin A3
NCBI Official Synonym Symbols
6.3; SEX; PLXN3; PLXN4; XAP-6; HSSEXGENE; PLEXIN-A3 [Similar Products]
NCBI Protein Information
plexin-A3; plexin-4; OTTHUMP00000032114; semaphorin receptor SEX; Sex chromosome X transmembrane protein of HGF receptor family 3
UniProt Protein Name
Plexin-A3
UniProt Synonym Protein Names
Plexin-4; Semaphorin receptor SEX
UniProt Synonym Gene Names
UniProt Entry Name
PLXA3_HUMAN
NCBI Summary for PLXNA3
The protein encoded by this gene is a member of the plexin class of proteins. The encoded protein is a transmembrane protein that is exposed on the cell surface. This gene is thought to be involved in epithelial and neural tissue development. [provided by RefSeq]
UniProt Comments for PLXNA3
PLXNA3: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with CBFA2T3/MTG16. Belongs to the plexin family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: membrane; integral to membrane; plasma membrane; intracellular
Molecular Function: protein binding; transmembrane receptor activity; semaphorin receptor activity
Biological Process: facial nerve structural organization; axon guidance; trigeminal nerve structural organization; branchiomotor neuron axon guidance; multicellular organismal development; hippocampus development; negative chemotaxis; positive regulation of cytoskeleton organization and biogenesis; pyramidal neuron development; negative regulation of axon extension involved in axon guidance
Research Articles on PLXNA3
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Pathways associated with anti-PLXNA3 antibody
Diseases associated with anti-PLXNA3 antibody
Organs/Tissues associated with anti-PLXNA3 antibody
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