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anti-PLXND1 antibody :: Goat Plexin D1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420760 anti-PLXND1 antibody
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Plexin D1 (PLXND1), Polyclonal Antibody

 Also Known As   

Goat anti-Plexin D1 Antibody

 Product Synonym Names    PLXND1; PLEXD1; KIAA0620; plexin D1; MGC75353; PLXND1 antibody; PLEXD1 antibody; KIAA0620 antibody; plexin D1 antibody; MGC75353 antibody; Plexin D1
 Product Gene Name   

anti-PLXND1 antibody

[Similar Products]
 Product Synonym Gene Name    Plexin D1 [Similar Products]
 Antibody/Peptide Pairs    Plexin D1 peptide (MBS425962) is used for blocking the activity of Plexin D1 antibody (MBS420760)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    LAEPKKSHRQ SH
 OMIM    604282
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse; Expected from sequence similarity: Human, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-LAEPKKSHRQSH, from the internal region of the protein sequence according to NP_055918.2.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-PLXND1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PLXND1 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PLXND1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Immunohistochemistry: A customer reported specific stain in Paraffin-embedded Mouse Brain after epitope retrieval in Citrate buffer pH6.
Western Blot: A customer reported a 250kDa band in Human Artherial endothelial cells lysates at 0.5ug/ml.
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NCBI/Uniprot data below describe general gene information for PLXND1. It may not necessarily be applicable to this product.
 NCBI GI #    157694524
 NCBI GeneID    23129
 NCBI Accession #    NP_055918.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_015103.2 [Other Products]
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 UniProt Secondary Accession #    Q6PJS9; Q8IZJ2; Q9BTQ2; A7E2C6; C9JPZ6 [Other Products]
 UniProt Related Accession #    Q9Y4D7 [Other Products]
 Molecular Weight    195,558 Da
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 NCBI Official Full Name    plexin-D1
 NCBI Official Synonym Full Names    plexin D1
 NCBI Official Symbol    PLXND1 [Similar Products]
 NCBI Official Synonym Symbols   
PLEXD1
[Similar Products]
 NCBI Protein Information    plexin-D1
 UniProt Protein Name    Plexin-D1
 Protein Family    Plexin
 UniProt Gene Name    PLXND1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0620 [Similar Products]
 UniProt Entry Name    PLXD1_HUMAN
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 UniProt Comments for PLXND1    PLXND1: Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature. Mediates anti-angiogenic signaling in response to SEMA3E. Belongs to the plexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: integral to plasma membrane; lamellipodium; plasma membrane

Molecular Function: protein binding; protein domain specific binding; semaphorin receptor activity

Biological Process: angiogenesis; branchiomotor neuron axon guidance; endothelial cell migration; patterning of blood vessels; positive regulation of protein binding; regulation of angiogenesis; regulation of axon extension involved in axon guidance; regulation of cell migration; synaptogenesis
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 Research Articles on PLXND1    1. finding that PLXND1 and REV3L mutations are responsible for a proportion of MBS patients suggests that de novo mutations in other genes might account for other MBS patients
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PLXND1 antibodyDiseases associated with anti-PLXND1 antibody
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Other Semaphorin Interactions Pathway antibodies  Other Semaphorin Interactions Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >5 publications with PLXND1 and Heart Diseases
 Lung Diseases Antibodies  >4 publications with PLXND1 and Lung Diseases
 Disease Models, Animal Antibodies  >4 publications with PLXND1 and Disease Models, Animal
 Brain Diseases Antibodies  >3 publications with PLXND1 and Brain Diseases
 Inflammation Antibodies  >3 publications with PLXND1 and Inflammation
 Eye Diseases Antibodies  >3 publications with PLXND1 and Eye Diseases
 Lung Neoplasms Antibodies  >2 publications with PLXND1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >2 publications with PLXND1 and Breast Neoplasms
 Anxiety Disorders Antibodies  >1 publications with PLXND1 and Anxiety Disorders
 Weight Gain Antibodies  >1 publications with PLXND1 and Weight Gain
Organs/Tissues associated with anti-PLXND1 antibody
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >41 publications with PLXND1 and Nerve
 Vascular Antibodies  >34 publications with PLXND1 and Vascular
 Blood Antibodies  >24 publications with PLXND1 and Blood
 Brain Antibodies  >19 publications with PLXND1 and Brain
 Embryonic Tissue Antibodies  >17 publications with PLXND1 and Embryonic Tissue
 Heart Antibodies  >8 publications with PLXND1 and Heart
 Muscle Antibodies  >6 publications with PLXND1 and Muscle
 Lung Antibodies  >4 publications with PLXND1 and Lung
 Adipose Tissue Antibodies  >4 publications with PLXND1 and Adipose Tissue
 Skin Antibodies  >4 publications with PLXND1 and Skin
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