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anti-Plk3 antibody :: Rabbit anti-Human, mouse Plk3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9208782
Unit / Price
0.08 mL  /  $155 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Plk3, Polyclonal Antibody

 Also Known As   

Mouse Plk3 Antibody (N-term)

 Product Synonym Names    Serine/threonine-protein kinase PLK3; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; Polo-like kinase 3; PLK-3; Plk3; Cnk; Fnk
 Product Gene Name   

anti-Plk3 antibody

[Similar Products]
 Antibody/Peptide Pairs    Plk3 peptide (MBS9221020) is used for blocking the activity of Plk3 antibody (MBS9208782)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    33-61
 3D Structure    ModBase 3D Structure for Q60806
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Specificity    This Mouse Plk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of mouse Plk3.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    MOUSE
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-Plk3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Plk3 antibody

   Serine/threonine protein kinase involved in regulating M phase functions during the cell cycle. May also be part of the signaling network controlling cellular adhesion. In vitro, is able to phosphorylate CDC25C and casein (By similarity).
 Product Categories/Family for anti-Plk3 antibody    Signal Transduction
 Applications Tested/Suitable for anti-Plk3 antibody   

Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)

 Application Notes for anti-Plk3 antibody    WB~~1:1000
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 Western Blot (WB) of anti-Plk3 antibody    Mouse Plk3 Antibody (N-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the Plk3 antibody detected the Plk3 protein (arrow).
anti-Plk3 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-Plk3 antibody    Mouse Plk3 Antibody (N-term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the Plk3 antibody detected the Plk3 protein (arrow).
anti-Plk3 antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC/FACS) of anti-Plk3 antibody    Mouse Plk3 Antibody (N-term) flow cytometric analysis of Neuro-2a cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
anti-Plk3 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for Plk3. It may not necessarily be applicable to this product.
 NCBI GI #    13878440
 NCBI Accession #    Q60806.2 [Other Products]
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 UniProt Primary Accession #    Q60806 [Other Products]
 UniProt Secondary Accession #    Q60822; Q9R009 [Other Products]
 Molecular Weight    70012
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 NCBI Official Full Name    Serine/threonine-protein kinase PLK3
 UniProt Protein Name    Serine/threonine-protein kinase PLK3
 UniProt Synonym Protein Names   
Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; Polo-like kinase 3; PLK-3
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    Plk3 [Similar Products]
 UniProt Synonym Gene Names    Cnk; Fnk; PLK-3 [Similar Products]
 UniProt Entry Name    PLK3_MOUSE
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 NCBI Summary for Plk3    This gene encodes a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal catalytic domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases have primarily been implicated in cell cycle regulation. In mouse, this protein that has been reported to localize to the nucleolus during interphase but is undetectable during mitosis, following nucleolus dissociation during prophase. The protein relocalizes to the nucleolus just prior to cytokinesis and peak levels are detected during G1 of interphase. This gene has been implicated in regulation of entry into S phase, with RNAi-induced depletion resulting in failure to re-enter the cell cycle. Mice deficient for this gene exhibit increased weight and tumor development at advanced age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
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 UniProt Comments for Plk3    PLK3: a kinase of the PLK family. Phosphorylated and activated following DNA damage or mitotic spindle disruption. Interacts with Chk2 and the interaction is enhanced upon DNA damage. Apparent substrates include Chk2 and p53. Plays an important role in regulating microtubule dynamics and centrosomal function. Deregulated expression of Plk3 results in cell cycle arrest and apoptosis.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Nucleolus; EC 2.7.11.21; Protein kinase, Other; Other group; PLK family

Cellular Component: Golgi apparatus; centrosome; Golgi stack; cytoskeleton; cell soma; cytoplasm; dendrite; nucleolus; intracellular; chromatin; nucleus

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; p53 binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity

Biological Process: apoptosis; negative regulation of transcription from RNA polymerase II promoter; response to osmotic stress; cell cycle; protein amino acid phosphorylation; regulation of cytokinesis; cytoplasmic microtubule organization and biogenesis; response to radiation; response to reactive oxygen species; protein kinase B signaling cascade; response to DNA damage stimulus; regulation of cell division; phosphorylation; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Plk3 antibodyOrgans/Tissues associated with anti-Plk3 antibody
 Reference Product  PubMed Publications
 Cdc25c antibody  >9 publications with Plk3 and Cdc25c
 Trp53 antibody  >8 publications with Plk3 and Trp53
 Cdc25a antibody  >4 publications with Plk3 and Cdc25a
 Ccnb1 antibody  >3 publications with Plk3 and Ccnb1
 Bub1 antibody  >1 publications with Plk3 and Bub1
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with Plk3 and Brain
 Liver Antibodies  >10 publications with Plk3 and Liver
 Eye Antibodies  >6 publications with Plk3 and Eye
 Lung Antibodies  >5 publications with Plk3 and Lung
 Bone Marrow Antibodies  >3 publications with Plk3 and Bone Marrow
 Skin Antibodies  >2 publications with Plk3 and Skin
 Mammary Gland Antibodies  >1 publications with Plk3 and Mammary Gland
 Kidney Antibodies  >1 publications with Plk3 and Kidney
 Ovary Antibodies  >1 publications with Plk3 and Ovary
 Intestine Antibodies  >1 publications with Plk3 and Intestine
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