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anti-PARP3 antibody :: Rabbit anti-Human, Mouse Poly [ADP-ribose] polymerase 3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1494765
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Poly [ADP-ribose] polymerase 3 (PARP3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Poly [ADP-ribose] polymerase 3 polyclonal Antibody(PARP3)

 Product Synonym Names    PARP-3; hPARP-3; ADP-ribosyltransferase diphtheria toxin-like 3; ARTD3; IRT1; NAD(+) ADP-ribosyltransferase 3; ADPRT-3; Poly[ADP-ribose] synthase 3; pADPRT-3; PARP3; ADPRT3; ADPRTL3
 Product Gene Name   

anti-PARP3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607726
 3D Structure    ModBase 3D Structure for Q9Y6F1
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Poly [ADP-ribose] polymerase 3 protein (294-533aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-30625 / sc-130838 / sc-133887
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PARP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PARP3 antibody

   Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
 Applications Tested/Suitable for anti-PARP3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PARP3 antibody    Recommended dilution: WB:1:500-2000
IHC:1:20-1:200
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 Western Blot (WB) of anti-PARP3 antibody    All lanes: Poly [ADP-ribose] polymerase 3 antibody at 2ug/ml+mouse heart tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 60kDa
Observed band size: 60kDa

anti-PARP3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PARP3 antibody    Immunohistochemistry of paraffin-embedded human kidney using MBS1494765 at dilution 1:100
anti-PARP3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PARP3 antibody    Immunofluorescent analysis of Hela cells cells using MBS1494765 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-PARP3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PARP3. It may not necessarily be applicable to this product.
 NCBI GI #    729042235
 NCBI GeneID    10039
 NCBI Accession #    NP_001003931.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001003931.3 [Other Products]
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 UniProt Primary Accession #    Q9Y6F1 [Other Products]
 UniProt Secondary Accession #    Q8NER9; Q96CG2; Q9UG81 [Other Products]
 UniProt Related Accession #    Q9Y6F1 [Other Products]
 Molecular Weight    60,846 Da
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 NCBI Official Full Name    poly
 NCBI Official Synonym Full Names    poly(ADP-ribose) polymerase family member 3
 NCBI Official Symbol    PARP3 [Similar Products]
 NCBI Official Synonym Symbols   
IRT1; ARTD3; ADPRT3; ADPRTL2; ADPRTL3; PADPRT-3
[Similar Products]
 NCBI Protein Information    poly [ADP-ribose] polymerase 3
 UniProt Protein Name    Poly [ADP-ribose] polymerase 3
 UniProt Synonym Protein Names   
ADP-ribosyltransferase diphtheria toxin-like 3; ARTD3; IRT1; NAD(+) ADP-ribosyltransferase 3; ADPRT-3; Poly[ADP-ribose] synthase 3; pADPRT-3
 Protein Family    Poly [ADP-ribose] polymerase
 UniProt Gene Name    PARP3 [Similar Products]
 UniProt Synonym Gene Names    ADPRT3; ADPRTL3; PARP-3; hPARP-3; ARTD3; ADPRT-3; pADPRT-3 [Similar Products]
 UniProt Entry Name    PARP3_HUMAN
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 NCBI Summary for PARP3    The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PARP3    PARP3: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.4.2.30; DNA repair, damage; Transferase

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: centriole; cytoplasm; nucleus

Molecular Function: catalytic activity; DNA ligase (ATP) activity; NAD+ ADP-ribosyltransferase activity

Biological Process: DNA ligation during DNA repair; DNA repair; double-strand break repair; lagging strand elongation; positive regulation of DNA ligation; protein amino acid ADP-ribosylation; telomere maintenance
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 Research Articles on PARP3    1. Identification of ADP-ribosylation sites in PARP3 and the determination of the extent ofpoly(ADP-ribosyl)ated residues in this protein was performed.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PARP3 antibodyPathways associated with anti-PARP3 antibody
 Reference Product  PubMed Publications
 PARP1 antibody  >23 publications with PARP3 and PARP1
 ATM antibody  >2 publications with PARP3 and ATM
 PARG antibody  >2 publications with PARP3 and PARG
 NUMA1 antibody  >1 publications with PARP3 and NUMA1
 XRCC1 antibody  >1 publications with PARP3 and XRCC1
 Products by Pathway  Pathway Diagram
 BER Complex Pathway antibodies  BER Complex Pathway Diagram
 BER Complex Pathway antibodies  BER Complex Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
Diseases associated with anti-PARP3 antibodyOrgans/Tissues associated with anti-PARP3 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >3 publications with PARP3 and Necrosis
 Lung Diseases Antibodies  >2 publications with PARP3 and Lung Diseases
 Drug Hypersensitivity Antibodies  >1 publications with PARP3 and Drug Hypersensitivity
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with PARP3 and Lung
 Blood Antibodies  >4 publications with PARP3 and Blood
 Skin Antibodies  >2 publications with PARP3 and Skin
 Brain Antibodies  >2 publications with PARP3 and Brain
 Testis Antibodies  >1 publications with PARP3 and Testis
 Nerve Antibodies  >1 publications with PARP3 and Nerve
 Ovary Antibodies  >1 publications with PARP3 and Ovary
 Kidney Antibodies  >1 publications with PARP3 and Kidney
 Liver Antibodies  >1 publications with PARP3 and Liver
 Intestine Antibodies  >1 publications with PARP3 and Intestine
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