NP_002855.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
163,863 Da
NCBI Official Full Name
pregnancy zone protein
NCBI Official Synonym Full Names
pregnancy-zone protein
NCBI Official Synonym Symbols
NCBI Protein Information
pregnancy zone protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
UniProt Protein Name
Pregnancy zone protein
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
UniProt Synonym Gene Names
UniProt Entry Name
PZP_HUMAN
UniProt Comments for PZP
PZP: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 12p13-p12.2
Cellular Component: extracellular region
Molecular Function: serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity
Biological Process: female pregnancy
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Products associated with anti-PZP antibody
Organs/Tissues associated with anti-PZP antibody
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