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anti-PXR antibody :: Rabbit Pregnane X Receptor (PXR) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2006061 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $185 +1 FREE 8GB USB
0.1 mg  /  $230 +1 FREE 8GB USB
0.2 mg  /  $345 +1 FREE 8GB USB
1 mg  /  $825 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pregnane X Receptor (PXR), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Pregnane X Receptor (PXR)

 Product Gene Name   

anti-PXR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF - YMFKGV INFAKVISYF RDLPIEDQIS LLKGATFEMC ILRFNTMFDT ETGTWECGRL AYCFEDPNGG FQKLLLDPLM KFHCMLKKLQ LHKEEYVLMQ AISLFSPDRP GVVQRSVVDQ LQERFALTLK AYIECSRPYP AHRFLFLKIM AVLTELRSIN AQQTQQLLRI QDSHPFATPL MQELFSSTDG
 3D Structure    ModBase 3D Structure for O54915
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mus musculus (Mouse)
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 Specificity    The antibody is a rabbit polyclonal antibody raised against PXR. It has been selected for its ability to recognize PXR in immunohistochemical staining andwestern blotting.
 Purity/Purification    Antigen-specific affinity chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH1.4, containing 0.05% Proclin-300, 50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Source    Polyclonal antibody preparation
 Traits    Liquid
 Immunogen    Recombinant PXR (Tyr205-Gly390) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2073698
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 Preparation and Storage    Avoid repeated freeze/thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.

Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 3rC for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-PXR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PXR antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-PXR antibody    Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-PXR antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-PXR antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PXR antibody    (Figure.DAB staining on IHC-P. Samples: Mouse Tissue)
anti-PXR antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PXR. It may not necessarily be applicable to this product.
 NCBI GI #    148536879
 NCBI GeneID    18171
 NCBI Accession #    NP_001091874.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001098404.1 [Other Products]
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 UniProt Primary Accession #    O54915 [Other Products]
 UniProt Related Accession #    O54915 [Other Products]
 Molecular Weight    44,958 Da
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 NCBI Official Full Name    nuclear receptor subfamily 1 group I member 2 isoform 2
 NCBI Official Synonym Full Names    nuclear receptor subfamily 1, group I, member 2
 NCBI Official Symbol    Nr1i2 [Similar Products]
 NCBI Official Synonym Symbols   
PXR; SXR; PXR1; mPXR; PXR.1; PXR.2
[Similar Products]
 NCBI Protein Information    nuclear receptor subfamily 1 group I member 2
 UniProt Protein Name    Nuclear receptor subfamily 1 group I member 2
 UniProt Synonym Protein Names   
Orphan nuclear receptor PXR; Pregnane X receptor
 UniProt Gene Name    Nr1i2 [Similar Products]
 UniProt Synonym Gene Names    Pxr [Similar Products]
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 UniProt Comments for PXR    PXR: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. Heterodimer with RXR. Interacts with NCOA1. Expressed in liver, colon and small intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 16|16 B3

Cellular Component: intermediate filament cytoskeleton; nuclear body; nucleoplasm; nucleus

Molecular Function: DNA binding; DNA binding transcription factor activity; drug binding; ligand-dependent nuclear receptor activity; metal ion binding; protein binding; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding

Biological Process: drug export; exogenous drug catabolic process; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; steroid hormone mediated signaling; transcription, DNA-dependent; xenobiotic metabolic process; xenobiotic transport
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 Research Articles on PXR    1. Both the acetylation and SUMOylation status of the PXR protein is affected by its ability to associate with the lysine de-acetylating enzyme HDAC3 in a complex with SMRT.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PXR antibodyDiseases associated with anti-PXR antibody
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with PXR and Neoplasms
 Drug Toxicity Antibodies  >13 publications with PXR and Drug Toxicity
 Gastrointestinal Diseases Antibodies  >13 publications with PXR and Gastrointestinal Diseases
 Liver Diseases Antibodies  >10 publications with PXR and Liver Diseases
 Carcinoma Antibodies  >9 publications with PXR and Carcinoma
 Cholestasis Antibodies  >8 publications with PXR and Cholestasis
 Adenocarcinoma Antibodies  >6 publications with PXR and Adenocarcinoma
 Inflammation Antibodies  >6 publications with PXR and Inflammation
 Liver Neoplasms Antibodies  >5 publications with PXR and Liver Neoplasms
 Cholestasis, Intrahepatic Antibodies  >4 publications with PXR and Cholestasis, Intrahepatic
Organs/Tissues associated with anti-PXR antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >54 publications with PXR and Liver
 Intestine Antibodies  >17 publications with PXR and Intestine
 Stomach Antibodies  >1 publications with PXR and Stomach
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