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anti-POMC antibody :: Rabbit anti-Human Pro-opiomelanocortin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1490231
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pro-opiomelanocortin (POMC), Polyclonal Antibody

 Also Known As   

Rabbit anti-human Pro-opiomelanocortin polyclonal Antibody

 Product Synonym Names    POMC; Corticotropin-lipotropin; Gamma-MSH; Adrenocorticotropic hormone; ACTH; Alpha-MSH; CLIP; Beta-LPH; Gamma-LPH; Beta-MSH; POMC
 Product Gene Name   

anti-POMC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176830
 3D Structure    ModBase 3D Structure for P01189
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Peptide
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16959 / sc-33034 / sc-33036 / sc-18262 / sc-18264 / sc-20148
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-POMC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-POMC antibody

   ACTH stimulates the adrenal glands to release cortisol.MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.Beta-endorphin and Met-enkephalin are endogenous opiates.
 Applications Tested/Suitable for anti-POMC antibody   

ELISA (EIA), Immunohistochemistry (IHC)

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 Immunohistochemistry (IHC) of anti-POMC antibody    Immunohistochemistry of paraffin-embedded human adrenal gland tissue at dilution 1:100
anti-POMC antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for POMC. It may not necessarily be applicable to this product.
 NCBI GI #    4505949
 NCBI GeneID    5443
 NCBI Accession #    NP_000930.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000939.3 [Other Products]
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 UniProt Primary Accession #    P01189 [Other Products]
 UniProt Secondary Accession #    P78442; Q53T23; Q9UD39; Q9UD40 [Other Products]
 UniProt Related Accession #    P01189 [Other Products]
 Molecular Weight    29,424 Da [Similar Products]
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 NCBI Official Full Name    pro-opiomelanocortin preproprotein
 NCBI Official Synonym Full Names    proopiomelanocortin
 NCBI Official Symbol    POMC [Similar Products]
 NCBI Official Synonym Symbols   
LPH; MSH; NPP; POC; ACTH; CLIP
[Similar Products]
 NCBI Protein Information    pro-opiomelanocortin
 UniProt Protein Name    Pro-opiomelanocortin
 UniProt Synonym Protein Names   
Corticotropin-lipotropin
 Protein Family    Pro-opiomelanocortin
 UniProt Gene Name    POMC [Similar Products]
 UniProt Synonym Gene Names    POMC; ACTH; CLIP [Similar Products]
 UniProt Entry Name    COLI_HUMAN
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 NCBI Summary for POMC    This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]
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 UniProt Comments for POMC    POMC: ACTH stimulates the adrenal glands to release cortisol. Defects in POMC may be associated with susceptibility to obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD). Affected individuals present early-onset obesity, adrenal insufficiency and red hair. Belongs to the POMC family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: cytoplasm; extracellular region; extracellular space; peroxisomal matrix; peroxisome; secretory granule

Molecular Function: G-protein-coupled receptor binding; hormone activity; receptor binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding

Biological Process: cell-cell signaling; cellular pigmentation; cellular protein metabolic process; generation of precursor metabolites and energy; glucose homeostasis; negative regulation of tumor necrosis factor production; neuropeptide signaling pathway; peptide hormone processing; positive regulation of transcription from RNA polymerase II promoter; regulation of appetite; regulation of blood pressure; signal transduction

Disease: Obesity; Proopiomelanocortin Deficiency
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 Research Articles on POMC    1. CSF POMC was higher in lean vs. overweight/obese subjects.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-POMC antibodyPathways associated with anti-POMC antibody
 Reference Product  PubMed Publications
 CRH antibody  >2258 publications with POMC and CRH
 NPY antibody  >854 publications with POMC and NPY
 MC4R antibody  >378 publications with POMC and MC4R
 MC1R antibody  >242 publications with POMC and MC1R
 CYP17A1 antibody  >202 publications with POMC and CYP17A1
 MC3R antibody  >157 publications with POMC and MC3R
 MC2R antibody  >135 publications with POMC and MC2R
 MC5R antibody  >94 publications with POMC and MC5R
 NR4A1 antibody  >43 publications with POMC and NR4A1
 PDYN antibody  >29 publications with POMC and PDYN
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Metabolism Pathway antibodies  Diseases Of Metabolism Pathway Diagram
Diseases associated with anti-POMC antibodyOrgans/Tissues associated with anti-POMC antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >4604 publications with POMC and Immune System Diseases
 Cushing Syndrome Antibodies  >2958 publications with POMC and Cushing Syndrome
 Mental Disorders Antibodies  >2764 publications with POMC and Mental Disorders
 Obesity Antibodies  >1826 publications with POMC and Obesity
 Infection Antibodies  >1167 publications with POMC and Infection
 Kidney Diseases Antibodies  >1067 publications with POMC and Kidney Diseases
 Gastrointestinal Diseases Antibodies  >1039 publications with POMC and Gastrointestinal Diseases
 Diabetes Mellitus Antibodies  >907 publications with POMC and Diabetes Mellitus
 Eye Diseases Antibodies  >711 publications with POMC and Eye Diseases
 Hemorrhage Antibodies  >710 publications with POMC and Hemorrhage
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19442 publications with POMC and Brain
 Pituitary Gland Antibodies  >9661 publications with POMC and Pituitary Gland
 Lung Antibodies  >1026 publications with POMC and Lung
 Eye Antibodies  >669 publications with POMC and Eye
 Testis Antibodies  >563 publications with POMC and Testis
 Intestine Antibodies  >466 publications with POMC and Intestine
 Embryonic Tissue Antibodies  >399 publications with POMC and Embryonic Tissue
 Placenta Antibodies  >376 publications with POMC and Placenta
 Uterus Antibodies  >260 publications with POMC and Uterus
 Uncharacterized Tissue Antibodies  >2 publications with POMC and Uncharacterized Tissue
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