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anti-CHMP1A antibody :: Rabbit anti-Human Procollagen Type III Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS316311 anti-CHMP1A antibody
Unit / Price
0.1 mL  /  $765 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Procollagen Type III (CHMP1A), Polyclonal Antibody

 Also Known As   

Rabbit A' Procollagen Type III

 Product Synonym Names    Rabbit Antibody to Human Procollagen Type III
 Product Gene Name   

anti-CHMP1A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (89710843..89724129, complement). Location: 16q24.3
 OMIM    164010
 3D Structure    ModBase 3D Structure for Q9HD42
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Procollagen Type III
Crossreactivity: (RIA%)
Human Procollagen, Type III - 100%
Human Procollagen, Type I - <0.1%
Bovine Procollagen, Types I - <0.1%
Bovine Procollagen, Type III - 100%
 Purity/Purification    Ion exchange chromatography (DEAE-Trisacryl)
 Form/Format    Purified, Lyophilized
Reconstitute with 0.5ml deionized water.
 Concentration    Not determined
Titer: 1:10,000 (RIA) (lot specific)
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 Immunogen    Purified Procollagen Type III Amino terminal peptide (PIII NP)
 Buffer    Not applicable
 Preservative    No
 Lyophilized    Yes
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
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 Preparation and Storage    Lyophilized: Short-term (up to 24 months) store at 2 to 8 degree C. Long term store at -20 degree C.
Reconstituted: Aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CHMP1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-CHMP1A antibody    Polyclonal Antibodies to Collagens and Extracellular Matrix Proteins
NCBI/Uniprot data below describe general gene information for CHMP1A. It may not necessarily be applicable to this product.
 NCBI GI #    119587121
 NCBI GeneID    5119
 NCBI Accession #    EAW66717.1 [Other Products]
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 UniProt Primary Accession #    Q9HD42 [Other Products]
 UniProt Secondary Accession #    Q14468; Q15779; Q96G31; A2RU09 [Other Products]
 UniProt Related Accession #    Q9HD42 [Other Products]
 Molecular Weight    21,703 Da [Similar Products]
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 NCBI Official Full Name    procollagen (type III) N-endopeptidase, isoform CRA_a
 NCBI Official Synonym Full Names    chromatin modifying protein 1A
 NCBI Official Symbol    CHMP1A [Similar Products]
 NCBI Official Synonym Symbols   
CHMP1; PRSM1; PCOLN3; VPS46A; VPS46-1; KIAA0047
[Similar Products]
 NCBI Protein Information    charged multivesicular body protein 1a; protease, metallo, 1, 33kD; procollagen (type III) N-endopeptidase; vacuolar protein sorting-associated protein 46-1; charged multivesicular body protein 1/chromatin modifying protein 1
 UniProt Protein Name    Charged multivesicular body protein 1a
 UniProt Synonym Protein Names   
Chromatin-modifying protein 1a; CHMP1a; Vacuolar protein sorting-associated protein 46-1
 Protein Family    ESCRT-related protein
 UniProt Gene Name    CHMP1A [Similar Products]
 UniProt Synonym Gene Names    CHMP1; KIAA0047; PCOLN3; PRSM1 [Similar Products]
 UniProt Entry Name    CHM1A_HUMAN
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 NCBI Summary for CHMP1A    This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein. [provided by RefSeq]
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 UniProt Comments for CHMP1A    Function: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. Ref.1 Ref.2 Ref.7 Ref.13

Subunit structure: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Self-associates. Interacts with CHMP1B. Interacts with VPS4A. Interacts with VPS4B. Interacts with PHF1. Interacts with IST1. Ref.7 Ref.8 Ref.9 Ref.12 Ref.13

Subcellular location: Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note: The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin. Ref.2 Ref.7

Tissue specificity: Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG63. Ref.1

Induction: By muristerone. Ref.2

Sequence similarities: Belongs to the SNF7 family.

Caution: Was originally (Ref.1) thought to be a metalloprotease (PRSM1). This was based on a wrong translation of the ORF which gave rise to a putative protein of 318 AA containing a pattern reminiscent of zinc metalloproteases.

Sequence caution: The sequence AAC50775.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.The sequence BAA07557.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.
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 Research Articles on CHMP1A    1. Both Vps4A and CHMP1A localized in the vicinity of viral cytoplasmic assembly compartments, sites of viral maturation that develop in Cytomegalovirus-infected cells. Thus, ESCRT machinery is involved in the final steps of HCMV replication.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CHMP1A antibodyDiseases associated with anti-CHMP1A antibody
 Reference Product  PubMed Publications
 VPS4A antibody  >6 publications with CHMP1A and VPS4A
 CHMP1B antibody  >6 publications with CHMP1A and CHMP1B
 STAMBP antibody  >3 publications with CHMP1A and STAMBP
 VPS4B antibody  >2 publications with CHMP1A and VPS4B
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >2 publications with CHMP1A and Adenocarcinoma
 Pancreatic Neoplasms Antibodies  >2 publications with CHMP1A and Pancreatic Neoplasms
 Kidney Diseases Antibodies  >1 publications with CHMP1A and Kidney Diseases
 Leukemia Antibodies  >1 publications with CHMP1A and Leukemia
 Neurodegenerative Diseases Antibodies  >1 publications with CHMP1A and Neurodegenerative Diseases
 Kidney Neoplasms Antibodies  >1 publications with CHMP1A and Kidney Neoplasms
 Nervous System Diseases Antibodies  >1 publications with CHMP1A and Nervous System Diseases
 Carcinoma, Small Cell Antibodies  >1 publications with CHMP1A and Carcinoma, Small Cell
Organs/Tissues associated with anti-CHMP1A antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with CHMP1A and Kidney
 Nerve Antibodies  >1 publications with CHMP1A and Nerve
 Pancreas Antibodies  >1 publications with CHMP1A and Pancreas
 Connective Tissue Antibodies  >1 publications with CHMP1A and Connective Tissue
 Embryonic Tissue Antibodies  >1 publications with CHMP1A and Embryonic Tissue
 Uterus Antibodies  >1 publications with CHMP1A and Uterus
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