NP_005013.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
15,054 Da
NCBI Official Full Name
profilin-1
NCBI Official Synonym Full Names
profilin 1
NCBI Official Synonym Symbols
NCBI Protein Information
profilin-1
UniProt Protein Name
Profilin-1
UniProt Synonym Protein Names
Epididymis tissue protein Li 184a; Profilin I
UniProt Entry Name
PROF1_HUMAN
NCBI Summary for PFN1
This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]
UniProt Comments for PFN1
profilin 1: a ubiquitous actin monomer-binding protein belonging to the profilin family. At high concentrations, profilin 1 prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Deletion of this gene is associated with Miller-Dieker syndrome.
Protein type: Cytoskeletal; Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: cell cortex; cytoplasm; cytoskeleton; cytosol; focal adhesion; membrane; nucleus
Molecular Function: actin binding; actin monomer binding; adenyl-nucleotide exchange factor activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding; Rho GTPase binding
Biological Process: actin cytoskeleton organization and biogenesis; blood coagulation; negative regulation of actin filament bundle formation; negative regulation of actin filament polymerization; negative regulation of stress fiber formation; neural tube closure; platelet activation; platelet degranulation; positive regulation of actin filament bundle formation; positive regulation of actin filament polymerization; positive regulation of ATPase activity; protein stabilization; regulation of transcription from RNA polymerase II promoter
Disease: Amyotrophic Lateral Sclerosis 18
Research Articles on PFN1
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Products associated with anti-PFN1 antibody
Pathways associated with anti-PFN1 antibody
Diseases associated with anti-PFN1 antibody
Organs/Tissues associated with anti-PFN1 antibody
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