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anti-PDCD6 antibody :: Rabbit anti-Human Programmed cell death protein 6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS715734
Western Blot (WB)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Programmed cell death protein 6 (PDCD6), Polyclonal Antibody

 Also Known As   

Rabbit anti-human Programmed cell death protein 6 polyclonal Antibody, Biotin conjugated

 Product Gene Name   

anti-PDCD6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601057
 3D Structure    ModBase 3D Structure for O75340
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Biotin
 Immunogen    Recombinant human Programmed cell death protein 6 protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-11255 / sc-292580
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PDCD6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-PDCD6 antibody

   Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca2+-regulated signals along the death pathway By similarity. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101.
 Applications Tested/Suitable for anti-PDCD6 antibody   

ELISA (EIA)

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 Western Blot (WB) of anti-PDCD6 antibody    Western blot All lanes: UV excision repair protein RAD23 homolog A antibody at at 2 /mlLane 1: EC109 whole cell lysateLane 2: 293T whole cell lysate SecondaryGoat polyclonal to Rabbit IgG at 1/15000 dilution Predicted band size: 21 kDa Observed band size: 36kDa Additional bands at: 60 kDa.We are unsure as to the identity of this extra band. Why is the actual band size different from the predicted Western blotting is a technique that separates proteins based on size - in general, the smaller the protein the faster it migrates through the gel. However, migration is also affected by other factors and so the actual band size observed may differ from that predicted. Common factors include... post-translational modification - e.g. phosphorylation, glycosylation etc which increases the size of the protein post-translation cleavage - e.g. many proteins are synthesized as pro-proteins, and then cleaved to give the active form, e.g. pro-caspases splice variants - alternative splicing may create different sized proteins from the same gene relative charge - the composition of amino acids (charged vs non-charged) multimers - e.g. dimerisation of a protein. This is usually prevented in reducing conditions, although strong interactions can result in the appearance of higher bands.
anti-PDCD6 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PDCD6. It may not necessarily be applicable to this product.
 NCBI GI #    389565483
 NCBI GeneID    10016
 NCBI Accession #    NP_001254485.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001267556.1 [Other Products]
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 UniProt Primary Accession #    O75340 [Other Products]
 UniProt Secondary Accession #    Q2YDC2; Q5TZS0; B2RD16; E7ESR3 [Other Products]
 UniProt Related Accession #    O75340 [Other Products]
 Molecular Weight    7,349 Da [Similar Products]
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 NCBI Official Full Name    programmed cell death protein 6 isoform 2
 NCBI Official Synonym Full Names    programmed cell death 6
 NCBI Official Symbol    PDCD6 [Similar Products]
 NCBI Official Synonym Symbols   
ALG2; ALG-2; PEF1B
[Similar Products]
 NCBI Protein Information    programmed cell death protein 6
 UniProt Protein Name    Programmed cell death protein 6
 UniProt Synonym Protein Names   
Apoptosis-linked gene 2 protein; Probable calcium-binding protein ALG-2
 Protein Family    Programmed cell death protein
 UniProt Gene Name    PDCD6 [Similar Products]
 UniProt Synonym Gene Names    ALG2 [Similar Products]
 UniProt Entry Name    PDCD6_HUMAN
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 NCBI Summary for PDCD6    This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]
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 UniProt Comments for PDCD6    PDCD6: Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; nuclear membrane; nucleus

Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; calcium-dependent protein binding; identical protein binding; molecular adaptor activity; protein anchor; protein binding; protein dimerization activity; protein homodimerization activity

Biological Process: angiogenesis; caspase activation; intracellular protein transport; negative regulation of protein kinase B signaling cascade; negative regulation of TOR signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of angiogenesis; positive regulation of caspase activity; positive regulation of endothelial cell proliferation; proteolysis; response to calcium ion
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 Research Articles on PDCD6    1. Our results suggest that PDCD6 may play an important role in the pathogenesis of cervical squamous cell carcinoma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PDCD6 antibodyDiseases associated with anti-PDCD6 antibody
 Reference Product  PubMed Publications
 PDCD6IP antibody  >21 publications with PDCD6 and PDCD6IP
 SEC31A antibody  >12 publications with PDCD6 and SEC31A
 TSG101 antibody  >9 publications with PDCD6 and TSG101
 PEF1 antibody  >3 publications with PDCD6 and PEF1
 MCOLN1 antibody  >1 publications with PDCD6 and MCOLN1
 SEC31B antibody  >1 publications with PDCD6 and SEC31B
 DAPK1 antibody  >1 publications with PDCD6 and DAPK1
 MAP3K5 antibody  >1 publications with PDCD6 and MAP3K5
 ANXA11 antibody  >1 publications with PDCD6 and ANXA11
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >6 publications with PDCD6 and Lung Neoplasms
 Brain Diseases Antibodies  >3 publications with PDCD6 and Brain Diseases
 Ovarian Neoplasms Antibodies  >3 publications with PDCD6 and Ovarian Neoplasms
 Ovarian Diseases Antibodies  >3 publications with PDCD6 and Ovarian Diseases
 Chromosome Aberrations Antibodies  >2 publications with PDCD6 and Chromosome Aberrations
 Uterine Cervical Neoplasms Antibodies  >2 publications with PDCD6 and Uterine Cervical Neoplasms
 Necrosis Antibodies  >2 publications with PDCD6 and Necrosis
 Urinary Bladder Neoplasms Antibodies  >1 publications with PDCD6 and Urinary Bladder Neoplasms
 Liver Neoplasms Antibodies  >1 publications with PDCD6 and Liver Neoplasms
Organs/Tissues associated with anti-PDCD6 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with PDCD6 and Blood
 Lung Antibodies  >6 publications with PDCD6 and Lung
 Kidney Antibodies  >4 publications with PDCD6 and Kidney
 Vascular Antibodies  >4 publications with PDCD6 and Vascular
 Brain Antibodies  >4 publications with PDCD6 and Brain
 Muscle Antibodies  >3 publications with PDCD6 and Muscle
 Ovary Antibodies  >3 publications with PDCD6 and Ovary
 Stomach Antibodies  >2 publications with PDCD6 and Stomach
 Eye Antibodies  >2 publications with PDCD6 and Eye
 Liver Antibodies  >2 publications with PDCD6 and Liver
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