NP_035302.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,036 Da
NCBI Official Full Name
proline dehydrogenase 1, mitochondrial
NCBI Official Synonym Full Names
proline dehydrogenase
NCBI Protein Information
proline dehydrogenase 1, mitochondrial
UniProt Protein Name
Proline dehydrogenase 1, mitochondrial
UniProt Synonym Protein Names
Proline oxidase
UniProt Synonym Gene Names
UniProt Comments for PRODH
PRODH: Converts proline to delta-1-pyrroline-5-carboxylate. Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1). HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome. Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4). A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. Belongs to the proline oxidase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - arginine and proline; EC 1.5.5.2; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 16 A3|16 11.19 cM
Cellular Component: mitochondrial inner membrane; mitochondrion
Molecular Function: amino acid binding; oxidoreductase activity; proline dehydrogenase activity
Biological Process: proline catabolic process; proline catabolic process to glutamate; proline metabolic process
Research Articles on PRODH
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Pathways associated with anti-PRODH antibody
Diseases associated with anti-PRODH antibody
Organs/Tissues associated with anti-PRODH antibody
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