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anti-PROM1 antibody :: Rabbit anti-Human Prominin 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540105 anti-PROM1 antibody
Unit / Price
0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Prominin 1 (PROM1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Prominin 1 Antibody

 Product Synonym Names    AC133; CD133; CORD12; Hematopoietic stem cell antigen; MCDR2; MSTP061; RP41; STGD4 antibody
 Product Gene Name   

anti-PROM1 antibody

[Similar Products]
 Matching Pairs    Antibody: Prominin 1 (MBS540105)
Positive Control: Prominin 1 (MBS543166)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603786
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Affinity Purified
 Concentration    0.50-0.95 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid regions 700-730 on CD133 protein
 Expression    Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level).
 Molecular Function    Actinin binding; Cadherin binding
 Structure    Interacts with CDHR1 and with actin filaments. Interacts with NAT8 and NAT8B.
 Subcellular Location    Apical cell membrane; Multi-pass membrane protein; Microvillus membrane; cilium; photoreceptor outer segment; Endoplasmic Reticulum-Golgi intermediate compartment
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-PROM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PROM1 antibody

   May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).
 Product Categories/Family for anti-PROM1 antibody    Primary Antibodies; Cancer Research; Tumor Suppressors; Prominin 1 Antibody
 Applications Tested/Suitable for anti-PROM1 antibody   

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-PROM1 antibody    Dot Blot: 1:2,000
ELISA: 1:2,000
Western Blot: 1:500-1:1,000
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NCBI/Uniprot data below describe general gene information for PROM1. It may not necessarily be applicable to this product.
 NCBI GI #    578808417
 NCBI GeneID    8842
 NCBI Accession #    XP_006714037.1 [Other Products]
 NCBI GenBank Nucleotide #    XM_006713974.3 [Other Products]
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 UniProt Secondary Accession #    Q6SV49; Q6SV50; Q6SV51; Q6SV52; Q6SV53; Q96EN6 [Other Products]
 UniProt Related Accession #    O43490 [Other Products]
 Molecular Weight    94,605 Da [Similar Products]
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 NCBI Official Full Name    prominin-1 isoform X11
 NCBI Official Synonym Full Names    prominin 1
 NCBI Official Symbol    PROM1 [Similar Products]
 NCBI Official Synonym Symbols   
RP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061
[Similar Products]
 NCBI Protein Information    prominin-1
 UniProt Protein Name    Prominin-1
 UniProt Synonym Protein Names   
Antigen AC133; Prominin-like protein 1; CD_antigen: CD133
 Protein Family    Prominin
 UniProt Gene Name    PROM1 [Similar Products]
 UniProt Synonym Gene Names    PROML1 [Similar Products]
 UniProt Entry Name    PROM1_HUMAN
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 NCBI Summary for PROM1    This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for PROM1    CD133: Binds cholesterol in cholesterol-containing plasma membrane microdomains. Proposed to play a role in apical plasma membrane organization of epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. Interacts with CDHR1 and with actin filaments. Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells. Expressed in adult retina by rod and cone photoreceptor cells. Belongs to the prominin family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cell surface

Chromosomal Location of Human Ortholog: 4p15.32

Cellular Component: apical plasma membrane; cell surface; endoplasmic reticulum; ER-Golgi intermediate compartment; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; microvillus membrane; photoreceptor outer segment; plasma membrane; vesicle

Molecular Function: actinin binding; cadherin binding; protein binding

Biological Process: photoreceptor cell maintenance; retina morphogenesis in camera-type eye

Disease: Cone-rod Dystrophy 12; Macular Dystrophy, Retinal, 2; Retinitis Pigmentosa 41; Stargardt Disease 4
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 Research Articles on PROM1    1. Our results suggest that ANXA3 can serve as a novel diagnostic biomarker and that the inhibition of ANXA3 may be a viable therapeutic option for the treatment of CD133+ liver-CSC-driven HCC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PROM1 antibodyDiseases associated with anti-PROM1 antibody
 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Colorectal Neoplasms Antibodies  >14 publications with PROM1 and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >11 publications with PROM1 and Adenocarcinoma
 Glioblastoma Antibodies  >9 publications with PROM1 and Glioblastoma
 Disease Models, Animal Antibodies  >6 publications with PROM1 and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >6 publications with PROM1 and Ovarian Neoplasms
 Neoplasm Metastasis Antibodies  >6 publications with PROM1 and Neoplasm Metastasis
 Fibrosis Antibodies  >5 publications with PROM1 and Fibrosis
 Colonic Neoplasms Antibodies  >5 publications with PROM1 and Colonic Neoplasms
 Inflammation Antibodies  >4 publications with PROM1 and Inflammation
 Liver Diseases Antibodies  >4 publications with PROM1 and Liver Diseases
Organs/Tissues associated with anti-PROM1 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >20 publications with PROM1 and Eye
 Brain Antibodies  >18 publications with PROM1 and Brain
 Liver Antibodies  >13 publications with PROM1 and Liver
 Lung Antibodies  >6 publications with PROM1 and Lung
 Nerve Antibodies  >5 publications with PROM1 and Nerve
 Intestine Antibodies  >4 publications with PROM1 and Intestine
 Embryonic Tissue Antibodies  >4 publications with PROM1 and Embryonic Tissue
 Placenta Antibodies  >3 publications with PROM1 and Placenta
 Testis Antibodies  >3 publications with PROM1 and Testis
 Stomach Antibodies  >2 publications with PROM1 and Stomach
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