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anti-POMC antibody :: Goat Proopiomelanocortin/POMC Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420379
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proopiomelanocortin/POMC, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-Proopiomelanocortin/POMC Antibody

 Product Synonym Names    POMC; proopiomelanocortin; Precursor of MSH, POC, ACTH, CLIP, adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating; hormone/ beta-endorphin; LPH; NPP; OTTHUMP00000119991; OTTHUMP00000200964; adrenocortic; POMC antibody; proopiomelanocortin antibody; Precursor of MSH; POC; ACTH; CLIP; adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin antibody; LPH antibody; NPP antibody; OTTHUMP00000119991 antibody; OTTHUMP00000200964 antibody; adrenocorticotropic hormone antibody; adrenocorticotropin antibody; alpha-melanocyte-stimulating hormone antibody; beta-LPH antibody; beta-MSH antibody; beta-melanocyte-stimulating hormone antibody; corticotropin-like intermediary peptide antibody; gamma-LPH antibody; gamma-MSH antibody; lipotropin beta antibody; lipotropin gamma antibody; melanotropin alpha antibody; melanotropin beta antibody; melanotropin gamma antibody; met-enkephalin antibody; pro-ACTH-endorphin antibody; proopiomelanocortin preproprotein antibody; Proopiomelanocortin; Proopiomelanocortin / POMC
 Product Gene Name   

anti-POMC antibody

[Similar Products]
 Antibody/Peptide Pairs    Proopiomelanocortin / POMC peptide (MBS425678) is used for blocking the activity of Proopiomelanocortin/POMC antibody (MBS420379)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS420379 Technical Datasheet    Technical Datasheet PDF
 Immunogen Sequence    NAIIKNAYKK GE
 OMIM    176830
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-NAIIKNAYKKGE, from the C Terminus of the protein sequence according to NP_000930.1; NP_001030333.1.
 Epitope    C Terminus
 Note    Both transcript variants encode the same protein. In Western blot, this product appears to react with the full length precursor protein only.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-POMC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-POMC antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-POMC antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Immunohistochemistry: In paraffin embedded Human Anterior Pituitary Gland shows vesilulate staining in glandular cells. Recommended concentration, 2-4ug/ml.
Western Blot: Approx 29kDa band observed in lysates of cell line NIH3T3 (calculated MW of 29.4kDa according to NP_000930.1 and NP_001030333.1). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-POMC antibody    (0.1ug/ml) staining of lysates of cell line NIH3T3 (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-POMC antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-POMC antibody    (2ug/ml) staining of paraffin embedded Human Pituitary Gland. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
anti-POMC antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for POMC. It may not necessarily be applicable to this product.
 NCBI GI #    4505949
 NCBI GeneID    5443
 NCBI Accession #    NP_000930.1 [Other Products]
 NCBI Related Accession #    NP_001030333.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000939.3 [Other Products]
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 UniProt Secondary Accession #    P78442; Q53T23; Q9UD39; Q9UD40 [Other Products]
 UniProt Related Accession #    P01189 [Other Products]
 Molecular Weight    29,424 Da
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 NCBI Official Full Name    pro-opiomelanocortin preproprotein
 NCBI Official Synonym Full Names    proopiomelanocortin
 NCBI Official Symbol    POMC [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    pro-opiomelanocortin
 UniProt Protein Name    Pro-opiomelanocortin
 UniProt Synonym Protein Names   
 Protein Family    Pro-opiomelanocortin
 UniProt Gene Name    POMC [Similar Products]
 UniProt Synonym Gene Names    POMC; ACTH; CLIP [Similar Products]
 UniProt Entry Name    COLI_HUMAN
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 NCBI Summary for POMC    This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]
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 UniProt Comments for POMC    POMC: ACTH stimulates the adrenal glands to release cortisol. Defects in POMC may be associated with susceptibility to obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD). Affected individuals present early-onset obesity, adrenal insufficiency and red hair. Belongs to the POMC family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: cytoplasm; extracellular region; extracellular space; peroxisomal matrix; peroxisome; secretory granule

Molecular Function: G-protein-coupled receptor binding; hormone activity; neuropeptide hormone activity; receptor binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding

Biological Process: cell-cell signaling; cellular pigmentation; generation of precursor metabolites and energy; glucose homeostasis; negative regulation of tumor necrosis factor production; neuropeptide signaling pathway; peptide hormone processing; positive regulation of transcription from RNA polymerase II promoter; regulation of appetite; regulation of blood pressure; signal transduction

Disease: Obesity; Proopiomelanocortin Deficiency
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 Research Articles on POMC    1. ACTH was readily detected at significantly higher levels in regions of ACTH-secreting adenomas and in normal anterior adenohypophysis compared with non-secreting adenoma and neurohypophysis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-POMC antibodyPathways associated with anti-POMC antibody
 Reference Product  PubMed Publications
 CRH antibody  >2296 publications with POMC and CRH
 NPY antibody  >906 publications with POMC and NPY
 MC4R antibody  >413 publications with POMC and MC4R
 MC1R antibody  >251 publications with POMC and MC1R
 CYP17A1 antibody  >205 publications with POMC and CYP17A1
 MC3R antibody  >169 publications with POMC and MC3R
 MC2R antibody  >145 publications with POMC and MC2R
 MC5R antibody  >99 publications with POMC and MC5R
 NR4A1 antibody  >43 publications with POMC and NR4A1
 PDYN antibody  >30 publications with POMC and PDYN
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Metabolism Pathway antibodies  Diseases Of Metabolism Pathway Diagram
Diseases associated with anti-POMC antibodyOrgans/Tissues associated with anti-POMC antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >4619 publications with POMC and Immune System Diseases
 Cushing Syndrome Antibodies  >2967 publications with POMC and Cushing Syndrome
 Mental Disorders Antibodies  >2780 publications with POMC and Mental Disorders
 Obesity Antibodies  >1853 publications with POMC and Obesity
 Infection Antibodies  >1178 publications with POMC and Infection
 Kidney Diseases Antibodies  >1068 publications with POMC and Kidney Diseases
 Gastrointestinal Diseases Antibodies  >1042 publications with POMC and Gastrointestinal Diseases
 Diabetes Mellitus Antibodies  >915 publications with POMC and Diabetes Mellitus
 Eye Diseases Antibodies  >713 publications with POMC and Eye Diseases
 Hemorrhage Antibodies  >710 publications with POMC and Hemorrhage
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19539 publications with POMC and Brain
 Pituitary Gland Antibodies  >9682 publications with POMC and Pituitary Gland
 Lung Antibodies  >1032 publications with POMC and Lung
 Eye Antibodies  >672 publications with POMC and Eye
 Testis Antibodies  >564 publications with POMC and Testis
 Intestine Antibodies  >469 publications with POMC and Intestine
 Embryonic Tissue Antibodies  >399 publications with POMC and Embryonic Tissue
 Placenta Antibodies  >377 publications with POMC and Placenta
 Uterus Antibodies  >260 publications with POMC and Uterus
 Uncharacterized Tissue Antibodies  >2 publications with POMC and Uncharacterized Tissue
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