NP_001177412.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
101,489 Da
NCBI Official Full Name
proprotein convertase subtilisin/kexin type 5 isoform 1 preproprotein
NCBI Official Synonym Full Names
proprotein convertase subtilisin/kexin type 5
NCBI Official Synonym Symbols
PC5; PC6; SPC6; b2b585Clo; b2b1549Clo [Similar Products]
NCBI Protein Information
proprotein convertase subtilisin/kexin type 5
UniProt Protein Name
Proprotein convertase subtilisin/kexin type 5
UniProt Synonym Protein Names
Proprotein convertase 5; PC5; Proprotein convertase 6; PC6; Subtilisin-like proprotein convertase 6; SPC6; Subtilisin/kexin-like protease PC5
UniProt Synonym Gene Names
NCBI Summary for PCSK5
This gene encodes a subtilisin-like proprotein convertase that mediates posttranslational endoproteolytic processing of various proprotein substrates traversing the secretory pathway. The encoded protein is an inactive zymogen that undergoes autoproteolytic processing in the endoplasmic reticulum and the Golgi network to generate an active enzyme. Mice lacking the encoded protein die at an early embryonic stage. Conditional inactivation this gene in the epiblast but not in the extraembryonic tissue bypasses embryonic lethality but results in death at birth. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]
UniProt Comments for PCSK5
PCSK5: Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2 and CALD1. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.21.-; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 19 B|19 12.86 cM
Cellular Component: extracellular space; Golgi apparatus; secretory granule
Molecular Function: endopeptidase activity; peptidase activity; peptide binding; serine-type endopeptidase activity
Biological Process: anterior/posterior pattern formation; cytokine biosynthetic process; determination of left/right symmetry; embryo implantation; embryonic gut development; embryonic skeletal development; heart development; kidney development; limb morphogenesis; peptide biosynthetic process; peptide hormone processing; protein processing; respiratory tube development; signal peptide processing; viral infectious cycle
Research Articles on PCSK5
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-PCSK5 antibody
Diseases associated with anti-PCSK5 antibody
Organs/Tissues associated with anti-PCSK5 antibody
|