NP_598544.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,324 Da
NCBI Official Full Name
prostaglandin E synthase 2
NCBI Official Synonym Full Names
prostaglandin E synthase 2
NCBI Official Synonym Symbols
Gbf1; Pges2; C79137; Mpges2; 0610038H10Rik [Similar Products]
NCBI Protein Information
prostaglandin E synthase 2
UniProt Protein Name
Prostaglandin E synthase 2
UniProt Synonym Protein Names
GATE-binding factor 1
UniProt Synonym Gene Names
NCBI Summary for PTGES2
The protein encoded by this gene is a Golgi membrane-associated prostaglandin E synthase candidate, which is capable of catalyzing the conversion of prostaglandin H2 to prostaglandin E2 in vitro. However, a study using mice deficient of this gene suggests that this enzyme does not contribute to prostaglandin E2 biosynthesis in vivo. This protein is synthesized as a Golgi membrane-bound protein, but its N-terminal hydrophobic region is cleaved off during protein maturation to produce the predominant soluble truncated form that still retains the enzyme activity. This soluble protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE), possibly via an interaction with CAAAT/enhancer-binding protein-beta. [provided by RefSeq, Oct 2009]
UniProt Comments for PTGES2
PTGES2: Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear. Belongs to the GST superfamily.
Protein type: EC 5.3.99.3; Isomerase; Lipid Metabolism - arachidonic acid; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2|2 B
Cellular Component: cytosol; mitochondrion; nucleus
Molecular Function: DNA binding
Biological Process: positive regulation of transcription, DNA-dependent; secretion
Research Articles on PTGES2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-PTGES2 antibody
Diseases associated with anti-PTGES2 antibody
Organs/Tissues associated with anti-PTGES2 antibody
|