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anti-HPGD antibody :: Goat Prostaglandin dehydrogenase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421451
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Prostaglandin dehydrogenase 1 (HPGD), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-Prostaglandin dehydrogenase 1 Antibody

 Product Synonym Names    HPGD; Prostaglandin dehydrogenase 1; PGDH1; 15-PGDH; hydroxyprostaglandin dehydrogenase 15-(NAD); PGDH; SDR36C1; NAD+-dependent 15-hydroxyprostaglandin dehydrogenase; short chain dehydrogenase/reductase family 36C, member 1; Prostaglandin dehydrogenase 1 antibody; HPGD antibody; PGDH1 antibody; 15-PGDH antibody; hydroxyprostaglandin dehydrogenase 15-(NAD) antibody; Prostaglandin dehydrogenase 1; Prostaglandin dehydrogenase 1
 Product Gene Name   

anti-HPGD antibody

[Similar Products]
 Antibody/Peptide Pairs    Prostaglandin dehydrogenase 1 peptide (MBS425280) is used for blocking the activity of Prostaglandin dehydrogenase 1 antibody (MBS421451)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DYDTTPFQAK TQ
 OMIM    119900
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-DYDTTPFQAKTQ, from the C Terminus of the protein sequence according to NP_000851.2.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-HPGD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HPGD antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-HPGD antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Immunohistochemistry: In paraffin embedded Human Colon shows strong cytoplasm staining of enterocytes. Recommended concentration, 2-4ug/ml.
Western Blot: Experiments gave bands at approx 26kDa and 50kDa in Human Duodenum lysates after 0.1ug/ml antibody staining. These bands correspond to earlier findings in literature with different antibodies (PMID: 11889207). This protein has a calculated MW of 29. 0kDa according to NP_000851. Recommended concentration: 0.1-1ug/ml.
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 Western Blot (WB) of anti-HPGD antibody    (0.1ug/ml) staining of Human Duodenum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-HPGD antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-HPGD antibody    (2.5ug/ml) staining of paraffin embedded Human Colon. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-HPGD antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HPGD. It may not necessarily be applicable to this product.
 NCBI GI #    31542939
 NCBI GeneID    3248
 NCBI Accession #    NP_000851.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000860.5 [Other Products]
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 UniProt Secondary Accession #    O00749; Q06F08; Q12998; B4DTA4; B4DU74; B4DV57; D3DP43; E7EV11 [Other Products]
 UniProt Related Accession #    P15428 [Other Products]
 Molecular Weight    21,526 Da
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 NCBI Official Full Name    15-hydroxyprostaglandin dehydrogenase
 NCBI Official Synonym Full Names    hydroxyprostaglandin dehydrogenase 15-(NAD)
 NCBI Official Symbol    HPGD [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
 UniProt Protein Name    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
 UniProt Synonym Protein Names   
Prostaglandin dehydrogenase 1; Short chain dehydrogenase/reductase family 36C member 1
 Protein Family    15-hydroxyprostaglandin dehydrogenase
 UniProt Gene Name    HPGD [Similar Products]
 UniProt Synonym Gene Names    PGDH1; SDR36C1; 15-PGDH [Similar Products]
 UniProt Entry Name    PGDH_HUMAN
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 NCBI Summary for HPGD    This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for HPGD    HPGD: Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of hypertrophic osteoarthropathy, primary, autosomal recessive, type 1 (PHOAR1). A disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. Defects in HPGD are the cause of cranioosteoarthropathy (COA). A form of osterarthropathy characterized by swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature. Defects in HPGD are a cause of isolated congenital nail clubbing (ICNC); also called clubbing of digits or hereditary acropachy. ICNC is a rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Tumor suppressor; EC

Chromosomal Location of Human Ortholog: 4q34-q35

Cellular Component: basolateral plasma membrane; cytoplasm; cytosol; nucleoplasm

Molecular Function: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; catalytic activity; NAD binding; prostaglandin E receptor activity; protein homodimerization activity

Biological Process: female pregnancy; lipoxygenase pathway; negative regulation of cell cycle; ovulation; parturition; prostaglandin metabolic process; transforming growth factor beta receptor signaling pathway

Disease: Digital Clubbing, Isolated Congenital; Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
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 Research Articles on HPGD    1. a homozygous 2-bp deletion (c.310_311delCT or p.L104AfsX3) was identified two primary hypertrophic osteoarthropathy siblings
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HPGD antibodyDiseases associated with anti-HPGD antibody
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Prostaglandin Synthesis And Regulation Pathway antibodies  Prostaglandin Synthesis And Regulation Pathway Diagram
 Synthesis Of Lipoxins (LX) Pathway antibodies  Synthesis Of Lipoxins (LX) Pathway Diagram
 Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway antibodies  Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Osteoarthropathy, Primary Hypertrophic Antibodies  >23 publications with HPGD and Osteoarthropathy, Primary Hypertrophic
 Inflammation Antibodies  >13 publications with HPGD and Inflammation
 Breast Neoplasms Antibodies  >4 publications with HPGD and Breast Neoplasms
 Pain Antibodies  >3 publications with HPGD and Pain
 Fibrosis Antibodies  >2 publications with HPGD and Fibrosis
 Arthritis, Rheumatoid Antibodies  >2 publications with HPGD and Arthritis, Rheumatoid
 Fetal Growth Retardation Antibodies  >2 publications with HPGD and Fetal Growth Retardation
 Prostatic Neoplasms Antibodies  >2 publications with HPGD and Prostatic Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with HPGD and Neoplasms, Experimental
Organs/Tissues associated with anti-HPGD antibody
 Organ/Tissue Name  Pubmed Publications
 Uterus Antibodies  >11 publications with HPGD and Uterus
 Embryonic Tissue Antibodies  >7 publications with HPGD and Embryonic Tissue
 Lung Antibodies  >6 publications with HPGD and Lung
 Placenta Antibodies  >6 publications with HPGD and Placenta
 Prostate Antibodies  >5 publications with HPGD and Prostate
 Muscle Antibodies  >4 publications with HPGD and Muscle
 Skin Antibodies  >4 publications with HPGD and Skin
 Intestine Antibodies  >3 publications with HPGD and Intestine
 Heart Antibodies  >3 publications with HPGD and Heart
 Stomach Antibodies  >2 publications with HPGD and Stomach
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