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anti-PSMa5 antibody :: Rabbit anti-Human Proteasome Subunit Alpha Type 5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2027800 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $340 +1 FREE 8GB USB
1 mg  /  $800 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proteasome Subunit Alpha Type 5 (PSMa5), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Proteasome Subunit Alpha Type 5 (PSMa5)

 Product Gene Name   

anti-PSMa5 antibody

[Similar Products]
 Matching Pairs    Antibody: Proteasome Subunit Alpha Type 5 (MBS2027800)
Antigen: Proteasome Subunit Alpha Type 5 (MBS2029884)
 Matching Pairs    Unconjugated Antibody: Proteasome Subunit Alpha Type 5 (MBS2027800)
APC-CY7 Conjugated Antibody: Proteasome Subunit Alpha Type 5 (PSMa5) (MBS2077664)
 Matching Pairs    Unconjugated Antibody: Proteasome Subunit Alpha Type 5 (MBS2027800)
PE Conjugated Antibody: Proteasome Subunit Alpha Type 5 (PSMa5) (MBS2077665)
 Matching Pairs    Unconjugated Antibody: Proteasome Subunit Alpha Type 5 (MBS2027800)
APC-CY7 Conjugated Antibody: Proteasome Subunit Alpha Type 5 (PSMa5) (MBS2077666)
 Matching Pairs    Unconjugated Antibody: Proteasome Subunit Alpha Type 5 (MBS2027800)
Cy3 Conjugated Antibody: Proteasome Subunit Alpha Type 5 (PSMa5) (MBS2077667)
 Matching Pairs    Unconjugated Antibody: Proteasome Subunit Alpha Type 5 (MBS2027800)
FITC Conjugated Antibody: Proteasome Subunit Alpha Type 5 (PSMa5) (MBS2077668)
 Matching Pairs    Unconjugated Antibody: Proteasome Subunit Alpha Type 5 (MBS2027800)
HRP Conjugated Antibody: Proteasome Subunit Alpha Type 5 (PSMa5) (MBS2077669)
 Matching Pairs    Unconjugated Antibody: Proteasome Subunit Alpha Type 5 (MBS2027800)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Proteasome Subunit Alpha Type 5 (MBS2027800)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Matching Pairs    Unconjugated Antibody: Proteasome Subunit Alpha Type 5 (MBS2027800)
Biotin Conjugated Antibody: Proteasome Subunit Alpha Type 5 (PSMa5) (MBS2096125)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    X61970 mRNA
 3D Structure    ModBase 3D Structure for P28066
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against PSMa5. It has beenselected for its ability to recognize PSMa5 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Liquid
 Concentration    200ug/ml (lot specific)
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 Fragment    PSMa5 (Met1~Ile241)
 Organism Species    Homo sapiens (Human)
 Conjugate    No Conjugate
 Immunogen    Recombinant PSMa5 (Met1~Ile241) expressed in E Coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2077666
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-PSMa5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-PSMa5 antibody    Knock-Out Validation Antibody
 Applications Tested/Suitable for anti-PSMa5 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-PSMa5 antibody    Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) Knockout Verification of anti-PSMa5 antibody    Knockout Verification: Lane 1: Wild-type Hela cell lysate; Lane 2: PSMa5 knockout Hela cell lysate; Predicted MW: 26,20kd Observed MW: 27kd Primary Ab: 1ug/ml Rabbit Anti-Human PSMa5 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-PSMa5 antibody Western Blot (WB) Knockout Verification (WB) image
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 Western Blot (WB) of anti-PSMa5 antibody    Western Blot; Sample: Lane1: Human Lung Tissue; Lane2: Human Hela Cells.
anti-PSMa5 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-PSMa5 antibody    Western Blot; Sample: Recombinant PSMa5, Human.
anti-PSMa5 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PSMa5 antibody    DAB staining on IHC-P; Samples: Human Stomach Tissue.
anti-PSMa5 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PSMa5 antibody    DAB staining on IHC-P; Samples: Human Brain Tissue
anti-PSMa5 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PSMa5 antibody    DAB staining on IHC-P; Samples: Human Kidney Tissue
anti-PSMa5 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PSMa5. It may not necessarily be applicable to this product.
 NCBI GI #    315138981
 NCBI GeneID    5686
 NCBI Accession #    NP_001186701.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001199772.1 [Other Products]
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 UniProt Primary Accession #    P28066 [Other Products]
 UniProt Secondary Accession #    Q3T1C1; Q6IBF7; B2R8F6; B4E2V4 [Other Products]
 UniProt Related Accession #    P28066 [Other Products]
 Molecular Weight    20,035 Da
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 NCBI Official Full Name    proteasome subunit alpha type-5 isoform 2
 NCBI Official Synonym Full Names    proteasome subunit alpha 5
 NCBI Official Symbol    PSMA5 [Similar Products]
 NCBI Official Synonym Symbols   
PSC5; ZETA
[Similar Products]
 NCBI Protein Information    proteasome subunit alpha type-5
 UniProt Protein Name    Proteasome subunit alpha type-5
 UniProt Synonym Protein Names   
Macropain zeta chain; Multicatalytic endopeptidase complex zeta chain; Proteasome zeta chain
 UniProt Gene Name    PSMA5 [Similar Products]
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 NCBI Summary for PSMa5    The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
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 UniProt Comments for PSMa5    PSMA5: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. PSMA5 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly. Up-regulated in colon cancer cell lines. Up-regulated in fetal Down syndrome (DS) brain. May be the target of the transcriptional activator NFE2L2. Expressed in fetal brain. Belongs to the peptidase T1A family.

Protein type: EC 3.4.25.1; Protease; Proteasome complex

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; nucleoplasm; nucleus; proteasome complex; proteasome core complex; proteasome core complex, alpha-subunit complex; secretory granule lumen

Molecular Function: protein binding; threonine endopeptidase activity

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; Fc-epsilon receptor signaling pathway; MAPK cascade; negative regulation of canonical Wnt signaling pathway; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; neutrophil degranulation; NIK/NF-kappaB signaling; positive regulation of canonical Wnt signaling pathway; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; post-translational protein modification; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; regulation of cellular amino acid metabolic process; regulation of hematopoietic stem cell differentiation; regulation of mRNA stability; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; transmembrane transport; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
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 Research Articles on PSMa5    1. Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PSMa5 antibodyPathways associated with anti-PSMa5 antibody
 Reference Product  PubMed Publications
 PSMA1 antibody  >6 publications with PSMa5 and PSMA1
 PSMA3 antibody  >6 publications with PSMa5 and PSMA3
 PSMA6 antibody  >3 publications with PSMa5 and PSMA6
 PSMB2 antibody  >3 publications with PSMa5 and PSMB2
 PSMB1 antibody  >2 publications with PSMa5 and PSMB1
 PSMA7 antibody  >2 publications with PSMa5 and PSMA7
 PSMA2 antibody  >2 publications with PSMa5 and PSMA2
 PSMB4 antibody  >1 publications with PSMa5 and PSMB4
 PSMA4 antibody  >1 publications with PSMa5 and PSMA4
 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
Diseases associated with anti-PSMa5 antibodyOrgans/Tissues associated with anti-PSMa5 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >4 publications with PSMa5 and Immune System Diseases
 Necrosis Antibodies  >2 publications with PSMa5 and Necrosis
 Hypertension Antibodies  >1 publications with PSMa5 and Hypertension
 Lung Neoplasms Antibodies  >1 publications with PSMa5 and Lung Neoplasms
 Adenocarcinoma Antibodies  >1 publications with PSMa5 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >1 publications with PSMa5 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >2 publications with PSMa5 and Prostate
 Blood Antibodies  >2 publications with PSMa5 and Blood
 Lung Antibodies  >2 publications with PSMa5 and Lung
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