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anti-PSMB4 antibody :: Rabbit anti-Human Proteasome subunit beta type-4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1490047
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proteasome subunit beta type-4 (PSMB4), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti- human Proteasome subunit beta type-4 polyclonal Antibody

 Product Synonym Names    26 kDa prosomal protein HsBPROS26 PROS-26 Macropain beta chain Multicatalytic endopeptidase complex beta chain Proteasome chain 3 HsN3
 Product Gene Name   

anti-PSMB4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602177
 3D Structure    ModBase 3D Structure for P28070
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Proteasome subunit beta type-4 protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-74864
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PSMB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PSMB4 antibody

   The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal macrophage proteasome. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
 Applications Tested/Suitable for anti-PSMB4 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-PSMB4 antibody    All lanes: Proteasome subunit beta type-4 Antibody at 2ug/ml+EC109 whole cell lysate
at 20 ug
Secondary
Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size: 29 kDa
Observed band size: 75 kDa

anti-PSMB4 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PSMB4 antibody    Immunohistochemistry of paraffin-embeded human colorectal carcinoma using MBS1490047 at dilution of 1:100
anti-PSMB4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PSMB4 antibody    Immunohistochemistry of paraffin-embeded human prostate using MBS1490047 at dilution of 1:100
anti-PSMB4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-PSMB4 antibody    Immunofluorescent analysis of MCF-7 cells using MBS1490047 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-PSMB4 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for PSMB4. It may not necessarily be applicable to this product.
 NCBI GI #    22538467
 NCBI GeneID    5692
 NCBI Accession #    NP_002787.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002796.2 [Other Products]
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 UniProt Primary Accession #    P28070 [Other Products]
 UniProt Secondary Accession #    P31148; Q5SZS5; Q6IBI4; Q969L6; B2R9L3 [Other Products]
 UniProt Related Accession #    P28070 [Other Products]
 Molecular Weight    29,204 Da [Similar Products]
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 NCBI Official Full Name    proteasome subunit beta type-4
 NCBI Official Synonym Full Names    proteasome subunit beta 4
 NCBI Official Symbol    PSMB4 [Similar Products]
 NCBI Official Synonym Symbols   
HN3; HsN3; PROS26; PROS-26
[Similar Products]
 NCBI Protein Information    proteasome subunit beta type-4
 UniProt Protein Name    Proteasome subunit beta type-4
 UniProt Synonym Protein Names   
26 kDa prosomal protein; HsBPROS26; PROS-26; Macropain beta chain; Multicatalytic endopeptidase complex beta chain; Proteasome beta chain; Proteasome chain 3; HsN3
 Protein Family    Proteasome
 UniProt Gene Name    PSMB4 [Similar Products]
 UniProt Synonym Gene Names    PROS26; HsBPROS26; PROS-26; HsN3 [Similar Products]
 UniProt Entry Name    PSB4_HUMAN
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 NCBI Summary for PSMB4    The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PSMB4    PSMB4: a proteasomal protein of the T1B peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.

Protein type: Cell cycle regulation; Protease; EC 3.4.25.1; Proteasome complex; Cytoskeletal

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytosol; nucleoplasm; nucleus; proteasome complex; proteasome core complex

Molecular Function: lipopolysaccharide binding; protein binding; threonine endopeptidase activity

Biological Process: activation of MAPKK activity; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; apoptosis; axon guidance; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; G1/S transition of mitotic cell cycle; gene expression; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; mitotic cell cycle; negative regulation of apoptosis; negative regulation of inflammatory response to antigenic stimulus; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; nerve growth factor receptor signaling pathway; polyamine metabolic process; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; programmed cell death; protein polyubiquitination; Ras protein signal transduction; regulation of amino acid metabolic process; regulation of apoptosis; regulation of mRNA stability; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; small GTPase mediated signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; vascular endothelial growth factor receptor signaling pathway; viral reproduction
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 Research Articles on PSMB4    1. Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-kappaB-miR-21 signaling, which may represent promising targets for novel specific therapies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PSMB4 antibodyPathways associated with anti-PSMB4 antibody
 Reference Product  PubMed Publications
 PSMB2 antibody  >3 publications with PSMB4 and PSMB2
 PSMA6 antibody  >2 publications with PSMB4 and PSMA6
 PSMD14 antibody  >1 publications with PSMB4 and PSMD14
 PSMA5 antibody  >1 publications with PSMB4 and PSMA5
 PSMB3 antibody  >1 publications with PSMB4 and PSMB3
 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
Diseases associated with anti-PSMB4 antibodyOrgans/Tissues associated with anti-PSMB4 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >6 publications with PSMB4 and Carcinoma
 Adenocarcinoma Antibodies  >5 publications with PSMB4 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >3 publications with PSMB4 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >3 publications with PSMB4 and Inflammation
 Liver Diseases Antibodies  >2 publications with PSMB4 and Liver Diseases
 Cardiovascular Diseases Antibodies  >2 publications with PSMB4 and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >2 publications with PSMB4 and Neoplasm Metastasis
 Liver Neoplasms Antibodies  >2 publications with PSMB4 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with PSMB4 and Cell Transformation, Neoplastic
 Heart Diseases Antibodies  >1 publications with PSMB4 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >4 publications with PSMB4 and Muscle
 Blood Antibodies  >3 publications with PSMB4 and Blood
 Bone Antibodies  >3 publications with PSMB4 and Bone
 Ovary Antibodies  >2 publications with PSMB4 and Ovary
 Liver Antibodies  >2 publications with PSMB4 and Liver
 Prostate Antibodies  >2 publications with PSMB4 and Prostate
 Heart Antibodies  >2 publications with PSMB4 and Heart
 Brain Antibodies  >2 publications with PSMB4 and Brain
 Intestine Antibodies  >1 publications with PSMB4 and Intestine
 Kidney Antibodies  >1 publications with PSMB4 and Kidney
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