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anti-PROC antibody :: Rabbit Protein C Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS440107 anti-PROC antibody
Unit / Price
0.2 mg  /  $240 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein C (PROC), Polyclonal Antibody

 Also Known As   

Protein C-tag (E12) Antibody

 Product Gene Name   

anti-PROC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176860
 3D Structure    ModBase 3D Structure for P04070
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 Clonality    Polyclonal
 Host    Rabbit
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 Specificity    Detects proteins with the Protein C-tag, EDQVDPRLIDGK
 Form/Format    200 ug/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
 Concentration    0.200 mg/ml (lot specific)
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 Origin    Protein C-tag (E12) is provided as an affinity purified rabbit polyclonal raised against a synthetic peptide, EDQVDPRLIDGK, derived from the heavy chain of human Protein C.
 Immunogen    Synthetic peptide EDQVDPRLIDGK
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 Preparation and Storage    Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
 Other Notes    Small volumes of anti-PROC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PROC antibody

   Protein C is a vitamin K-dependent serine protease that regulates blood coagluation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids.
 Applications Tested/Suitable for anti-PROC antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-PROC antibody    Protein C-tag (E12) DB119 is recommended for use by western blotting and ELISA. The suggested western blotting starting dilution is at 1:400.
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NCBI/Uniprot data below describe general gene information for PROC. It may not necessarily be applicable to this product.
 NCBI GI #    265668
 NCBI GeneID    5624
 NCBI Accession #    AAB25410.1 [Other Products]
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 UniProt Primary Accession #    P04070 [Other Products]
 UniProt Secondary Accession #    Q15189; Q15190; Q16001; Q53S74; Q9UC55; B4DPQ7 [Other Products]
 UniProt Related Accession #    P04070 [Other Products]
 Molecular Weight    57,556 Da [Similar Products]
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 NCBI Official Full Name    protein C, partial
 NCBI Official Synonym Full Names    protein C (inactivator of coagulation factors Va and VIIIa)
 NCBI Official Symbol    PROC [Similar Products]
 NCBI Official Synonym Symbols   
PC; APC; PROC1; THPH3; THPH4
[Similar Products]
 NCBI Protein Information    vitamin K-dependent protein C; anticoagulant protein C; autoprothrombin IIA; blood coagulation factor XIV; prepro-protein C; type I protein C
 UniProt Protein Name    Vitamin K-dependent protein C
 UniProt Synonym Protein Names   
Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV
 Protein Family    Protein
 UniProt Gene Name    PROC [Similar Products]
 UniProt Entry Name    PROC_HUMAN
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 NCBI Summary for PROC    This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
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 UniProt Comments for PROC    PROC: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal dominant (THPH3). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. However, many adults with heterozygous disease may be asymptomatic. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency. Defects in PROC are the cause of thrombophilia due to protein C deficiency, autosomal recessive (THPH4). A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare. Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.69; Protease; Apoptosis

Chromosomal Location of Human Ortholog: 2q13-q14

Cellular Component: Golgi lumen; endoplasmic reticulum lumen; extracellular region

Molecular Function: protein binding; serine-type endopeptidase activity; calcium ion binding

Biological Process: cellular protein metabolic process; negative regulation of blood coagulation; proteolysis; blood coagulation; post-translational protein modification; leukocyte migration; peptidyl-glutamic acid carboxylation; negative regulation of apoptosis

Disease: Thrombophilia Due To Protein C Deficiency, Autosomal Recessive; Thrombophilia Due To Protein C Deficiency, Autosomal Dominant
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Product References and Citations for anti-PROC antibody

   1.) Kamil JP, Coen DM. 2007. Human cytomegalovirus protein kinase UL97 forms a complex with the tegument phosphoprotein pp65. J Virol. Oct;81(19):10659-68.
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 Research Articles on PROC    1. Dialysis patients who are carriers of the AG/GG genotypes of the PROC rs1799809 had a 1.2-fold increased 5-year all-cause mortality risk.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PROC antibodyPathways associated with anti-PROC antibody
 Reference Product  PubMed Publications
 SERPINC1 antibody  >108 publications with PROC and SERPINC1
 SERPINE1 antibody  >80 publications with PROC and SERPINE1
 PF4 antibody  >13 publications with PROC and PF4
 PROCR antibody  >8 publications with PROC and PROCR
 PROS1 antibody  >8 publications with PROC and PROS1
 GGCX antibody  >8 publications with PROC and GGCX
 SERPINA5 antibody  >5 publications with PROC and SERPINA5
 THBD antibody  >5 publications with PROC and THBD
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Common Pathway Of Fibrin Clot Formation antibodies  Common Pathway Of Fibrin Clot Formation Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway antibodies  Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway Diagram
 Gamma-carboxylation Of Protein Precursors Pathway antibodies  Gamma-carboxylation Of Protein Precursors Pathway Diagram
 Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies  Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-PROC antibodyOrgans/Tissues associated with anti-PROC antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >13310 publications with PROC and Cardiovascular Diseases
 Kidney Diseases Antibodies  >7591 publications with PROC and Kidney Diseases
 Liver Diseases Antibodies  >6186 publications with PROC and Liver Diseases
 Heart Diseases Antibodies  >5860 publications with PROC and Heart Diseases
 Inflammation Antibodies  >4191 publications with PROC and Inflammation
 Necrosis Antibodies  >3214 publications with PROC and Necrosis
 Hypertension Antibodies  >3191 publications with PROC and Hypertension
 Pain Antibodies  >2509 publications with PROC and Pain
 Cell Transformation, Neoplastic Antibodies  >2468 publications with PROC and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >1918 publications with PROC and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >24578 publications with PROC and Kidney
 Brain Antibodies  >22287 publications with PROC and Brain
 Liver Antibodies  >19814 publications with PROC and Liver
 Lung Antibodies  >7000 publications with PROC and Lung
 Spleen Antibodies  >4106 publications with PROC and Spleen
 Connective Tissue Antibodies  >3283 publications with PROC and Connective Tissue
 Uterus Antibodies  >1324 publications with PROC and Uterus
 Testis Antibodies  >1269 publications with PROC and Testis
 Mammary Gland Antibodies  >528 publications with PROC and Mammary Gland
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