anti-PARK7 antibody :: Rabbit Protein DJ-1 Polyclonal Antibody
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, mouse, rat
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Immunogen
Recombinant human Protein DJ-1 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27006 / sc-27004 / sc-32874
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-PARK7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-PARK7 antibody
PARK7/DJ1 is a ubiquitously expressed protein involved in various cellular processes including cell proliferation, RNA-binding, and oxidative stress. The protein has been found to colocalize within a subset of pathologic tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies (Rizzu et al. 2004). Defects in PARK7/DJ1 are the cause of autosomal recessive early-onset Parkinson's disease 7 (PARK7). Parkinson's disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. The disease is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK7 is characterized by onset before 40 years and slow progression. It has also been suggested that PARK7/DJ1 is a mitogen dependent oncogene product involved in Ras related signal transduction pathways.
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
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Applications Tested/Suitable for
anti-PARK7 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Western Blot (WB) of
anti-PARK7 antibody
Western blot
All lanes: Protein DJ-1 antibody at 2ug/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size: 20 kDa
Observed band size: 20kDa
Immunohistochemistry (IHC) of
anti-PARK7 antibody
Immunohistochemistry of paraffin-embeded human mammary gland using MBS7003881 at dilution of 1:50
Immunohistochemistry (IHC) of
anti-PARK7 antibody
Immunohistochemistry of paraffin-embeded human prostate using MBS7003881 at dilution of 1:50
NCBI/Uniprot data below describe general gene information for
PARK7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001116849.1
[Other Products]
NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
protein deglycase DJ-1
NCBI Official Synonym Full Names
Parkinsonism associated deglycase
NCBI Protein Information
protein deglycase DJ-1
UniProt Protein Name
Protein deglycase DJ-1
UniProt Synonym Protein Names
Oncogene DJ1; Parkinson disease protein 7
UniProt Synonym Gene Names
UniProt Entry Name
PARK7_HUMAN
NCBI Summary for PARK7
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PARK7
DJ-1: associated with autosomal recessive early onset parkinsonism. Involved in the oxidative stress response. Three cysteines in DJ-1 may be oxidized to cysteine sulphonic acid in the cellular response to H2O2. Loss of DJ-1 function may lead to neurodegeneration.
Protein type: EC 3.4.-.-; Tumor suppressor; Nuclear receptor co-regulator; Transcription regulation
Chromosomal Location of Human Ortholog: 1p36.23
Cellular Component: axon; chromatin; cytoplasm; cytosol; endoplasmic reticulum; lipid raft; mitochondrial intermembrane space; mitochondrial matrix; mitochondrial respiratory chain complex I; mitochondrion; nucleus; plasma membrane; PML body
Molecular Function: androgen receptor binding; copper ion binding; cytokine binding; double-stranded DNA binding; enzyme binding; glyoxalase III activity; identical protein binding; kinase binding; mercury ion binding; mRNA binding; oxidoreductase activity, acting on peroxide as acceptor; peptidase activity; peroxiredoxin activity; protein binding; protein homodimerization activity; receptor binding; single-stranded DNA binding; superoxide dismutase copper chaperone activity; transcription coactivator activity; transcription factor binding
Biological Process: activation of protein kinase B; adult locomotory behavior; autophagy; detoxification of copper ion; detoxification of mercury ion; dopamine uptake; enzyme active site formation via L-cysteine sulfinic acid; glycolate biosynthetic process; hydrogen peroxide metabolic process; inflammatory response; lactate biosynthetic process; membrane depolarization; membrane hyperpolarization; methylglyoxal catabolic process to D-lactate; mitochondrion organization and biogenesis; negative regulation of apoptosis; negative regulation of neuron apoptosis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein amino acid phosphorylation; negative regulation of protein binding; negative regulation of protein export from nucleus; negative regulation of protein kinase activity; negative regulation of protein sumoylation; negative regulation of protein ubiquitination; negative regulation of ubiquitin-protein ligase activity; positive regulation of interleukin-8 production; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein deglycosylation; protein stabilization; proteolysis; Ras protein signal transduction; regulation of inflammatory response; regulation of mitochondrial membrane potential; regulation of neuron apoptosis; regulation of TRAIL receptor biosynthetic process; response to drug; single fertilization
Disease: Parkinson Disease 7, Autosomal Recessive Early-onset
Research Articles on PARK7
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-PARK7 antibody
Pathways associated with anti-PARK7 antibody
Diseases associated with anti-PARK7 antibody
Organs/Tissues associated with anti-PARK7 antibody
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