AAN04036.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,707 Da
NCBI Official Full Name
protein kinase B-alpha
NCBI Official Synonym Full Names
thymoma viral proto-oncogene 1
NCBI Official Synonym Symbols
Akt; PKB; Rac; PKB/Akt; PKBalpha [Similar Products]
NCBI Protein Information
RAC-alpha serine/threonine-protein kinase; PKB alpha; AKT1 kinase; RAC-PK-alpha; proto-oncogene c-AKT; protein kinase B alpha; protein kinase B-alpha; related to A and C kinases
UniProt Protein Name
RAC-alpha serine/threonine-protein kinase
UniProt Synonym Protein Names
AKT1 kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha; Thymoma viral proto-oncogene
UniProt Synonym Gene Names
UniProt Entry Name
AKT1_MOUSE
NCBI Summary for PKBa
This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for PKBa
Akt1: an oncogenic AGC kinase that plays a critical role in regulating cell survival and metabolism in many different signaling pathways. Dual phosphorylation is required for its activation. T308 is phosphorylated by PDK1 in the PI3 kinase pathway, and S473 is phosphorylated by mTOR in the mTORC2 pathway. The 'Lys-63'-linked ubiquitination of AKT1 by TRAF6 is important for its translocation to the plasma membrane, phosphorylation, and activation. When Akt is fully phosphorylated it translocates into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its proteosomal degradation. Hyperactive or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Over 160 protein substrates are known including many that regulate transcription, metabolism, apoptosis, cell cycle, and growth.
Protein type: Kinase, protein; Protein kinase, AGC; EC 2.7.11.1; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); AGC group; AKT family
Cellular Component: microtubule cytoskeleton; nucleoplasm; protein complex; mitochondrion; membrane; cytoplasm; plasma membrane; spindle; intracellular; intercellular junction; nucleus; cytosol
Molecular Function: identical protein binding; protein phosphatase 2A binding; nitric-oxide synthase regulator activity; nucleotide binding; protein kinase binding; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; enzyme binding; protein kinase C binding; transferase activity, transferring phosphorus-containing groups; protein serine/threonine/tyrosine kinase activity; kinase activity; phosphatidylinositol-3,4-bisphosphate binding; ATP binding
Biological Process: glycogen metabolic process; negative regulation of JNK cascade; regulation of myelination; positive regulation of nitric oxide biosynthetic process; positive regulation of apoptosis; multicellular organismal development; protein ubiquitination; glucose homeostasis; regulation of cell migration; protein amino acid phosphorylation; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; germ cell development; positive regulation of glucose import; regulation of protein localization; cell projection organization and biogenesis; protein catabolic process; maternal placenta development; response to food; nervous system development; glycogen biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of blood vessel endothelial cell migration; carbohydrate transport; glucose metabolic process; positive regulation of lipid biosynthetic process; positive regulation of cell growth; cellular response to insulin stimulus; insulin-like growth factor receptor signaling pathway; carbohydrate metabolic process; striated muscle cell differentiation; positive regulation of fat cell differentiation; negative regulation of protein kinase activity; positive regulation of transcription factor activity; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; anagen; negative regulation of apoptosis; negative regulation of autophagy; negative regulation of fatty acid beta-oxidation; translation; apoptosis; positive regulation of glycogen biosynthetic process; positive regulation of cellular protein metabolic process; regulation of glycogen biosynthetic process; response to hormone stimulus; negative regulation of cell size; glucose transport; negative regulation of caspase activity; signal transduction; regulation of translation; apoptotic mitochondrial changes; transport; lipopolysaccharide-mediated signaling pathway; protein kinase B signaling cascade; inflammatory response; activated T cell apoptosis; aging; negative regulation of proteolysis; myelin maintenance in the peripheral nervous system; cytoskeleton organization and biogenesis; positive regulation of peptidyl-serine phosphorylation; osteoblast differentiation; peptidyl-serine phosphorylation; protein import into nucleus, translocation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; insulin receptor signaling pathway; positive regulation of vasoconstriction; positive regulation of protein amino acid phosphorylation; phosphorylation
Research Articles on PKBa
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-PKBa antibody
Diseases associated with anti-PKBa antibody
Organs/Tissues associated with anti-PKBa antibody
|