NP_002711.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,080 Da
NCBI Official Full Name
serine/threonine-protein phosphatase 4 catalytic subunit
NCBI Official Synonym Full Names
protein phosphatase 4, catalytic subunit
NCBI Protein Information
serine/threonine-protein phosphatase 4 catalytic subunit; PP-X; protein phosphatase X, catalytic subunit; protein phosphatase 4 (formerly X), catalytic subunit
UniProt Protein Name
Serine/threonine-protein phosphatase 4 catalytic subunit
UniProt Synonym Protein Names
Protein phosphatase X
UniProt Synonym Gene Names
UniProt Entry Name
PP4C_HUMAN
UniProt Comments for PP4C
Function: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase
By similarity. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. Ref.1 Ref.5 Ref.6 Ref.7 Ref.9 Ref.11 Ref.12 Ref.14 Ref.15 Ref.16
Catalytic activity: A phosphoprotein + H2O = a protein + phosphate.
Cofactor: Binds 1 iron ion per subunit
By similarity.Binds 1 manganese ion per subunit
By similarity.
Subunit structure: Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1/p50 and RELA. Interacts with SMN1 AND GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with SMEK1/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3. Ref.1 Ref.7 Ref.8 Ref.9 Ref.10 Ref.13 Ref.15
Subcellular location: Cytoplasm. Nucleus. Cytoplasm › cytoskeleton › centrosome.
Sequence similarities: Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
Research Articles on PP4C
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Products associated with anti-PP4C antibody
Diseases associated with anti-PP4C antibody
Organs/Tissues associated with anti-PP4C antibody
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