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anti-PTPRS antibody :: Chicken anti-Human Protein Tyrosine Phosphatase, Receptor Type sigma Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS621163 anti-PTPRS antibody
Unit / Price
0.05 mg  /  $540 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein Tyrosine Phosphatase, Receptor Type sigma (PTPRS), Polyclonal Antibody

 Also Known As   

Protein Tyrosine Phosphatase, Receptor Type sigma (PTPRS)

 Product Synonym Names    Anti -Protein Tyrosine Phosphatase, Receptor Type sigma (PTPRS)
 Product Gene Name   

anti-PTPRS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    chromosome: 19; Location: 19p13.3
 3D Structure    ModBase 3D Structure for Q59FX6
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 Clonality    Polyclonal
 Isotype    IgY
 Host    Chicken
 Species Reactivity    Human
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 Specificity    Recognizes human Protein Tyrosine Phosphatase, Receptor Type sigma.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2. No preservative added. Glycerol free.
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 Immunogen    Synthetic peptide corresponding to aa330-524
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-PTPRS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PTPRS antibody

   This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair.
 Product Categories/Family for anti-PTPRS antibody    Antibodies; Abs to Enzymes, Phosphatase
 Applications Tested/Suitable for anti-PTPRS antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-PTPRS antibody    Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:500-1:1000
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NCBI/Uniprot data below describe general gene information for PTPRS. It may not necessarily be applicable to this product.
 NCBI GI #    62088246
 NCBI GeneID    5802
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 UniProt Primary Accession #    Q59FX6 [Other Products]
 UniProt Related Accession #    Q13332; Q16343; Q2M3R7; Q59FX6; Q8NHS7; Q9UM81 [Other Products]
 Molecular Weight    174,656 Da [Similar Products]
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 NCBI Official Full Name    protein tyrosine phosphatase, receptor type, sigma isoform 3 variant
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, receptor type, S
 NCBI Official Symbol    PTPRS [Similar Products]
 NCBI Official Synonym Symbols   
PTPSIGMA; PTPRS
[Similar Products]
 NCBI Protein Information    receptor-type tyrosine-protein phosphatase S; R-PTP-S; R-PTP-sigma; protein tyrosine phosphatase PTPsigma; receptor-type tyrosine-protein phosphatase sigma; protein tyrosine phosphatase, receptor type, sigma
 UniProt Protein Name    Protein tyrosine phosphatase, receptor type, sigma isoform 3 variant
 Protein Family    Receptor-type tyrosine-protein phosphatase
 UniProt Entry Name    Q59FX6_HUMAN
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 NCBI Summary for PTPRS    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq]
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 UniProt Comments for PTPRS    PTPRS: Interacts with LAR-interacting protein LIP.1. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.48; Membrane protein, integral; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: integral to plasma membrane

Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity

Biological Process: corpus callosum development; extracellular matrix organization and biogenesis; spinal cord development; hippocampus development; cerebellum development; cerebral cortex development; cell adhesion
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 Research Articles on PTPRS    1. The receptor protein tyrosine phosphatase sigma (RPTPsigma) has now been identified as a receptor for inhibitory chondroitin sulfate proteoglycans.
2. Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.
3. In colorectal tumors, microsatellite repeats mutation rates are higher than the mean mutation frequency
4. Observational study of gene-disease association. (HuGE Navigator)
5. Three SNPs that flank exon 8 are associated with ulcerative colitis. The presence of these SNPs is associated with novel splicing that removes the third immunoglobulin-like domain (exon 9) from the extracellular portion of PTPsigma.
6. SNPs rs1143699, rs4807015, and rs1978237 confer an increased risk of developing type 2 diabetes mellitus.
7. Transient overexpression of the short splice variant 3 of RPTPR Sigma conferred alpha-LTX induced secretion to hamster insulinoma (HIT-15) cells. In contrast, the long splice variant 2 was inactive in secretion or in a single cell assay.
8. interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PTPRS antibodyDiseases associated with anti-PTPRS antibody
 Reference Product  PubMed Publications
 PTPRD antibody  >33 publications with PTPRS and PTPRD
 PTPRA antibody  >6 publications with PTPRS and PTPRA
 EGFR antibody  >4 publications with PTPRS and EGFR
 PTPRM antibody  >2 publications with PTPRS and PTPRM
 PTPRN antibody  >1 publications with PTPRS and PTPRN
 PTPRE antibody  >1 publications with PTPRS and PTPRE
 PPFIA1 antibody  >1 publications with PTPRS and PPFIA1
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >9 publications with PTPRS and Neoplasms
 Carcinoma Antibodies  >4 publications with PTPRS and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >3 publications with PTPRS and Cell Transformation, Neoplastic
 Congenital Abnormalities Antibodies  >2 publications with PTPRS and Congenital Abnormalities
 Spinal Cord Injuries Antibodies  >2 publications with PTPRS and Spinal Cord Injuries
 Wasting Syndrome Antibodies  >2 publications with PTPRS and Wasting Syndrome
 Craniofacial Abnormalities Antibodies  >2 publications with PTPRS and Craniofacial Abnormalities
 Cleft Palate Antibodies  >2 publications with PTPRS and Cleft Palate
 Neoplasm Recurrence, Local Antibodies  >2 publications with PTPRS and Neoplasm Recurrence, Local
 Prostatic Neoplasms Antibodies  >1 publications with PTPRS and Prostatic Neoplasms
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