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anti-PADI2 antibody :: Rabbit anti-Human Protein-arginine deiminase type-2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7000390
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Protein-arginine deiminase type-2 (PADI2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Protein-arginine deiminase type-2 polyclonal Antibody

 Product Synonym Names    PAD-H19; Peptidylarginine deiminase II; Protein-arginine deiminase type II
 Product Gene Name   

anti-PADI2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607935
 3D Structure    ModBase 3D Structure for Q9Y2J8
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Protein-arginine deiminase type-2 protein(1-665aa)
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48620 / sc-133877
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PADI2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PADI2 antibody

   Catalyzes the deimination of arginine residues of proteins.

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
 Applications Tested/Suitable for anti-PADI2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PADI2 antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Western Blot (WB) of anti-PADI2 antibody    Western blot
All lanes: Protein-arginine deiminase type-2 antibody at 20ug/ml
Lane 1: Hela whole cell lysate
Lane 2: Mouse brain tissue
Lane 3: MDA-MB-231 whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 76,50 kDa
Observed band size: 76 kDa

anti-PADI2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PADI2 antibody    Immunohistochemistry of paraffin-embedded human breast cancer using MBS7000390 at dilution 1:100
anti-PADI2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PADI2 antibody    Immunohistochemistry of paraffin-embedded human liver using MBS7000390 at dilution 1:100
anti-PADI2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-PADI2 antibody    Western Blot
Positive WB detected in: Rat brain tissue,Mouse brain tissue
All lanes: PADI2 antibody at 3.4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 76,50 KDa
Observed band size: 76 KDa

anti-PADI2 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-PADI2 antibody    Immunofluorescent analysis of PC3 cells using MBS7000390 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-PADI2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for PADI2. It may not necessarily be applicable to this product.
 NCBI GI #    122939159
 NCBI GeneID    11240
 NCBI Accession #    NP_031391.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007365.2 [Other Products]
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 UniProt Primary Accession #    Q9Y2J8 [Other Products]
 UniProt Secondary Accession #    Q96DA7; Q9UPN2 [Other Products]
 UniProt Related Accession #    Q9Y2J8 [Other Products]
 Molecular Weight    49,310 Da
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 NCBI Official Full Name    protein-arginine deiminase type-2
 NCBI Official Synonym Full Names    peptidyl arginine deiminase, type II
 NCBI Official Symbol    PADI2 [Similar Products]
 NCBI Official Synonym Symbols   
PAD2; PDI2; PAD-H19
[Similar Products]
 NCBI Protein Information    protein-arginine deiminase type-2
 UniProt Protein Name    Protein-arginine deiminase type-2
 UniProt Synonym Protein Names   
PAD-H19; Peptidylarginine deiminase II; Protein-arginine deiminase type II
 Protein Family    Protein-arginine deiminase
 UniProt Gene Name    PADI2 [Similar Products]
 UniProt Synonym Gene Names    KIAA0994; PAD2; PDI2 [Similar Products]
 UniProt Entry Name    PADI2_HUMAN
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 NCBI Summary for PADI2    This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PADI2    PADI2: Catalyzes the deimination of arginine residues of proteins. Belongs to the protein arginine deiminase family.

Protein type: EC 3.5.3.15; Hydrolase

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: cytoplasm

Molecular Function: calcium ion binding; estrogen receptor binding; protein-arginine deiminase activity

Biological Process: chromatin-mediated maintenance of transcription; estrogen receptor signaling pathway; peptidyl-citrulline biosynthetic process from peptidyl-arginine; substantia nigra development
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 Research Articles on PADI2    1. PAD2 activity was detected in synovial fluid samples from patients with rheumatoid arthritis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PADI2 antibodyDiseases associated with anti-PADI2 antibody
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Protein Citrullination Pathway antibodies  Protein Citrullination Pathway Diagram
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with PADI2 and Disease Models, Animal
 Inflammation Antibodies  >2 publications with PADI2 and Inflammation
 Kidney Diseases Antibodies  >1 publications with PADI2 and Kidney Diseases
 Breast Neoplasms Antibodies  >1 publications with PADI2 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >1 publications with PADI2 and Cardiovascular Diseases
 Necrosis Antibodies  >1 publications with PADI2 and Necrosis
Organs/Tissues associated with anti-PADI2 antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >4 publications with PADI2 and Skin
 Blood Antibodies  >4 publications with PADI2 and Blood
 Kidney Antibodies  >2 publications with PADI2 and Kidney
 Spleen Antibodies  >1 publications with PADI2 and Spleen
 Liver Antibodies  >1 publications with PADI2 and Liver
 Lung Antibodies  >1 publications with PADI2 and Lung
 Prostate Antibodies  >1 publications with PADI2 and Prostate
 Trachea Antibodies  >1 publications with PADI2 and Trachea
 Brain Antibodies  >1 publications with PADI2 and Brain
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