NP_005798.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
146,468 Da
NCBI Official Full Name
proteoglycan 4 isoform A preproprotein
NCBI Official Synonym Full Names
proteoglycan 4
NCBI Protein Information
proteoglycan 4
UniProt Protein Name
Proteoglycan 4
UniProt Synonym Protein Names
Lubricin; Megakaryocyte-stimulating factor; Superficial zone proteoglycan
UniProt Synonym Gene Names
NCBI Summary for PRG4
The protein encoded by this gene is a large proteoglycan that is synthesized by chondrocytes located at the surface of articular cartilage and by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Comments for PRG4
PRG4: Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Defects in PRG4 are the cause of camptodactyly- arthropathy-coxa vara-pericarditis syndrome (CACP); also known as Jacobs syndrome. CACP is an autosomal recessive disorder. Individuals with CACP have normal appearing joints at birth but with advancing age develop joint failure associated with noninflammatory synoviocyte hyperplasia and subintimal fibrosis of the synovial capsule. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q31.1
Biological Process: cell proliferation
Disease: Camptodactyly-arthropathy-coxa Vara-pericarditis Syndrome
Research Articles on PRG4
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Products associated with anti-PRG4 antibody
Diseases associated with anti-PRG4 antibody
Organs/Tissues associated with anti-PRG4 antibody
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