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anti-PKM2 antibody :: Rabbit anti-Human Pyruvate Kinase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2026646 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $165 +1 FREE 8GB USB
0.1 mg  /  $210 +1 FREE 8GB USB
0.2 mg  /  $310 +1 FREE 8GB USB
1 mg  /  $725 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pyruvate Kinase (PKM2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Pyruvate Kinase, Muscle (PKM2)

 Product Gene Name   

anti-PKM2 antibody

[Similar Products]
 Matching Pairs    Antibody: Pyruvate Kinase (MBS2026646)
Antigen: Pyruvate Kinase, Muscle (PKM2) (MBS2009852)
 Matching Pairs    Unconjugated Antibody: Pyruvate Kinase (MBS2026646)
APC: Pyruvate Kinase (PKM2) (MBS2044621)
 Matching Pairs    Unconjugated Antibody: Pyruvate Kinase (MBS2026646)
PE Conjugated Antibody: Pyruvate Kinase (PKM2) (MBS2044623)
 Matching Pairs    Unconjugated Antibody: Pyruvate Kinase (MBS2026646)
APC: Pyruvate Kinase (PKM2) (MBS2044625)
 Matching Pairs    Unconjugated Antibody: Pyruvate Kinase (MBS2026646)
Cy3 Conjugated Antibody: Pyruvate Kinase (PKM2) (MBS2044627)
 Matching Pairs    Unconjugated Antibody: Pyruvate Kinase (MBS2026646)
FITC Conjugated Antibody: Pyruvate Kinase (PKM2) (MBS2044629)
 Matching Pairs    Unconjugated Antibody: Pyruvate Kinase (MBS2026646)
HRP Conjugated Antibody: Pyruvate Kinase (PKM2) (MBS2044631)
 Matching Pairs    Unconjugated Antibody: Pyruvate Kinase (MBS2026646)
APC: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Pyruvate Kinase (MBS2026646)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Matching Pairs    Unconjugated Antibody: Pyruvate Kinase (MBS2026646)
Biotin Conjugated Antibody: Pyruvate Kinase, Muscle (PKM2) (MBS2092193)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M23725 mRNA
 3D Structure    ModBase 3D Structure for P14618
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is aRabbit polyclonalantibody raised againstPKM2. It has been selected for its ability to recognizePKM2 in immunohistochemical staining and western blotting.
 Purity/Purification    Antigen-specific Affinity Chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
 Concentration    200g/mL (lot specific)
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 Source    Polyclonal antibody preparation
 Traits    Liquid
 Immunogen    Recombinant PKM2 (Arg294~Phe470) expressed in E.coli
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2044625
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-PKM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PKM2 antibody   

WB; IHC; ICC; IP

 Application Notes for anti-PKM2 antibody    Western blotting: 0.5-2g/mL
Immunohistochemistry: 5-20g/mL
Immunocytochemistry: 5-20g/mL

Optimal working dilutions must be determined by end user
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 Western Blot (WB) of anti-PKM2 antibody    (Figure. Western Blot; Sample: Lane1: Human A549 Cells; Lane2: Human HepG2 Cells; Lane3: Human Hela Cells.)
anti-PKM2 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-PKM2 antibody    (Figure. Western Blot; Sample: Recombinant PKM2, Human.)
anti-PKM2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-PKM2 antibody    (Figure. DAB staining on IHC-P; Samples: Human Rectum Cancer Tissue.)
anti-PKM2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PKM2 antibody    (Figure. DAB staining on IHC-P; Samples: Human Breast Cancer Tissue.)
anti-PKM2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PKM2 antibody    (Figure. DAB staining on IHC-P; Samples: Human Pancreas Cancer Tissue.)
anti-PKM2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-PKM2 antibody    (Figure. DAB staining on IHC-P; Samples: Human Prostate Gland Tissue.)
anti-PKM2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PKM2. It may not necessarily be applicable to this product.
 NCBI GI #    332164775
 NCBI GeneID    5315
 NCBI Accession #    NP_001193725.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206796.2 [Other Products]
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 UniProt Primary Accession #    P14618 [Other Products]
 UniProt Secondary Accession #    P14786; Q53GK4; Q96E76; Q9BWB5; Q9UCV6; Q9UPF2; A6NFK3; B2R5N8; B3KRY0; B4DFX8; B4DUU6 [Other Products]
 UniProt Related Accession #    P14618 [Other Products]
 Molecular Weight    56,273 Da
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 NCBI Official Full Name    pyruvate kinase PKM isoform c
 NCBI Official Synonym Full Names    pyruvate kinase M1/2
 NCBI Official Symbol    PKM [Similar Products]
 NCBI Official Synonym Symbols   
PK3; TCB; OIP3; PKM2; CTHBP; THBP1; HEL-S-30
[Similar Products]
 NCBI Protein Information    pyruvate kinase PKM
 UniProt Protein Name    Pyruvate kinase PKM
 UniProt Synonym Protein Names   
Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tumor M2-PK; p58
 Protein Family    Pyruvate kinase
 UniProt Gene Name    PKM [Similar Products]
 UniProt Synonym Gene Names    OIP3; PK2; PK3; PKM2; CTHBP; OIP-3; THBP1 [Similar Products]
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 NCBI Summary for PKM2    This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]
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 UniProt Comments for PKM2    Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
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 Research Articles on PKM2    1. These findings uncover a novel mechanism through which mitochondrial PKM2 phosphorylates Bcl2 and inhibits apoptosis directly.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PKM2 antibodyDiseases associated with anti-PKM2 antibody
 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Conversion Of Glucose To Acetyl CoA And Entry Into The TCA Cycle Pathway antibodies  Conversion Of Glucose To Acetyl CoA And Entry Into The TCA Cycle Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
 Glycolysis Pathway antibodies  Glycolysis Pathway Diagram
 Glycolysis (Embden-Meyerhof Pathway), Glucose => Pyruvate antibodies  Glycolysis (Embden-Meyerhof Pathway), Glucose => Pyruvate Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >21 publications with PKM2 and Neoplasms
 Drug Toxicity Antibodies  >9 publications with PKM2 and Drug Toxicity
 Lung Diseases Antibodies  >8 publications with PKM2 and Lung Diseases
 Fibrosis Antibodies  >8 publications with PKM2 and Fibrosis
 Nervous System Diseases Antibodies  >8 publications with PKM2 and Nervous System Diseases
 Inflammation Antibodies  >6 publications with PKM2 and Inflammation
 Cardiovascular Diseases Antibodies  >6 publications with PKM2 and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >5 publications with PKM2 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >4 publications with PKM2 and Liver Diseases
 Necrosis Antibodies  >4 publications with PKM2 and Necrosis
Organs/Tissues associated with anti-PKM2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >49 publications with PKM2 and Brain
 Blood Antibodies  >35 publications with PKM2 and Blood
 Muscle Antibodies  >20 publications with PKM2 and Muscle
 Kidney Antibodies  >14 publications with PKM2 and Kidney
 Liver Antibodies  >13 publications with PKM2 and Liver
 Heart Antibodies  >10 publications with PKM2 and Heart
 Nerve Antibodies  >8 publications with PKM2 and Nerve
 Vascular Antibodies  >8 publications with PKM2 and Vascular
 Lung Antibodies  >7 publications with PKM2 and Lung
 Intestine Antibodies  >4 publications with PKM2 and Intestine
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