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anti-QDPR antibody :: Rabbit anti-Human, mouse QDPR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9210777
Unit / Price
0.08 mL  /  $155 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

QDPR, Polyclonal Antibody

 Also Known As   

QDPR Antibody (C-term)

 Product Synonym Names    Dihydropteridine reductase; HDHPR; Quinoid dihydropteridine reductase; QDPR; DHPR
 Product Gene Name   

anti-QDPR antibody

[Similar Products]
 Antibody/Peptide Pairs    QDPR peptide (MBS9227880) is used for blocking the activity of QDPR antibody (MBS9210777)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    218-243
 OMIM    261630
 3D Structure    ModBase 3D Structure for P09417
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Specificity    This QDPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-243 amino acids from the C-terminal region of human QDPR.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-QDPR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-QDPR antibody

   QDPR is the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems.
 Product Categories/Family for anti-QDPR antibody    Metabolism; Signal Transduction
 Applications Tested/Suitable for anti-QDPR antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-QDPR antibody    WB~~1:1000
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 Western Blot (WB) of anti-QDPR antibody    Western blot analysis of QDPR Antibody (C-term) in mouse liver tissue lysates (35ug/lane). QDPR (arrow) was detected using the purified Pab.
anti-QDPR antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-QDPR antibody    Formalin-fixed and paraffin-embedded human brain tissue reacted with QDPR Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-QDPR antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-QDPR antibody    Western blot analysis of QDPR (arrow) using rabbit polyclonal QDPR Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the QDPR gene.
anti-QDPR antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for QDPR. It may not necessarily be applicable to this product.
 NCBI GI #    208973246
 NCBI GeneID    5860
 NCBI Accession #    NP_000311.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000320.2 [Other Products]
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 UniProt Primary Accession #    P09417 [Other Products]
 UniProt Secondary Accession #    Q53F52; Q9H3M5; A8K158; B3KW71 [Other Products]
 UniProt Related Accession #    P09417 [Other Products]
 Molecular Weight    25790
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 NCBI Official Full Name    dihydropteridine reductase isoform 1
 NCBI Official Synonym Full Names    quinoid dihydropteridine reductase
 NCBI Official Symbol    QDPR [Similar Products]
 NCBI Official Synonym Symbols   
DHPR; PKU2; SDR33C1
[Similar Products]
 NCBI Protein Information    dihydropteridine reductase
 UniProt Protein Name    Dihydropteridine reductase
 UniProt Synonym Protein Names   
HDHPR; Quinoid dihydropteridine reductase; Short chain dehydrogenase/reductase family 33C member 1
 Protein Family    Dihydropteridine reductase
 UniProt Gene Name    QDPR [Similar Products]
 UniProt Synonym Gene Names    DHPR; SDR33C1 [Similar Products]
 UniProt Entry Name    DHPR_HUMAN
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 NCBI Summary for QDPR    This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, insertions, or premature terminations. Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. [provided by RefSeq, Jul 2008]
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 UniProt Comments for QDPR    QDPR: The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases. Defects in QDPR are the cause of BH4-deficient hyperphenylalaninemia type C (HPABH4C); also called dihydropteridine reductase deficiency (DHPR deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to DHPR deficiency or quinoid dihydropteridine reductase deficiency (QDPR deficiency). HPABH4C is a rare autosomal recessive disorder characterized by hyperphenylalaninemia and severe neurologic symptoms (malignant hyperphenylalaninemia) including axial hypotonia and truncal hypertonia, abnormal thermogenesis, and microcephaly. These signs are attributable to depletion of the neurotransmitters dopamine and serotonin, whose syntheses are controlled by tryptophan and tyrosine hydroxylases that use BH-4 as cofactor. These patients do not respond to phenylalanine- restricted diet. HPABH4C is lethal if untreated. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: EC 1.5.1.34; Cofactor and Vitamin Metabolism - folate biosynthesis; Oxidoreductase

Chromosomal Location of Human Ortholog: 4p15.31

Cellular Component: neuron projection; mitochondrion; cytoplasm; cytosol

Molecular Function: protein homodimerization activity; electron carrier activity; 6,7-dihydropteridine reductase activity

Biological Process: amino acid metabolic process; tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process; response to glucagon stimulus; dihydrobiopterin metabolic process; response to lead ion; liver development; response to aluminum ion

Disease: Hyperphenylalaninemia, Bh4-deficient, C
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Product References and Citations for anti-QDPR antibody

   Schnetz-Boutaud,N.C., et.al.,Genes Brain Behav. 8 (8), 753-757 (2009)
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 Research Articles on QDPR    1. The mutation spectrum of the QDPR gene is different in the Chinese population. Most mutations are related to severe phenotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-QDPR antibodyPathways associated with anti-QDPR antibody
 Reference Product  PubMed Publications
 PAH antibody  >6 publications with QDPR and PAH
 PCBD1 antibody  >4 publications with QDPR and PCBD1
 SPR antibody  >3 publications with QDPR and SPR
 Products by Pathway  Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
Diseases associated with anti-QDPR antibodyOrgans/Tissues associated with anti-QDPR antibody
 Disease Name  Pubmed Publications
 Phenylketonurias Antibodies  >10 publications with QDPR and Phenylketonurias
 HYPERPHENYLALANINEMIA, BH4-DEFICIENT, C Antibodies  >10 publications with QDPR and HYPERPHENYLALANINEMIA, BH4-DEFICIENT, C
 Cognition Disorders Antibodies  >4 publications with QDPR and Cognition Disorders
 Atrophy Antibodies  >1 publications with QDPR and Atrophy
 Fibrosis Antibodies  >1 publications with QDPR and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with QDPR and Blood
 Brain Antibodies  >6 publications with QDPR and Brain
 Kidney Antibodies  >2 publications with QDPR and Kidney
 Nerve Antibodies  >1 publications with QDPR and Nerve
 Lung Antibodies  >1 publications with QDPR and Lung
 Liver Antibodies  >1 publications with QDPR and Liver
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