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anti-QIP1 antibody :: Goat QIP1 / KPNA4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241960
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

QIP1 / KPNA4, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human QIP1 / KPNA4

 Product Synonym Names    Anti-QIP1 / KPNA4 Antibody (C-Terminus) IHC-plus; KPNA4; Importin subunit alpha-4; Importin alpha Q1; Karyopherin subunit alpha-4; SRP3; IPOA3; QIP1; Human QIP1; KPNA4
 Product Gene Name   

anti-QIP1 antibody

[Similar Products]
 Product Synonym Gene Name    KPNA4 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602970
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Bat, Gibbon, Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Rabbit
Predicted Reactivity: Mouse, Rat, Chicken, Xenopus (at least 90% immunogen sequence identity)
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 Specificity    Human KPNA4.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide C-NSSANVPTEGFQF from the C-terminus of human KPNA4 (NP_002259.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bovine, Dog, Bat, Hamster, Elephant, Panda, Horse, Rabbit, Opossum (100%).
 Immunogen Type    Synthetic peptide
 Immunogen    QIP1 / KPNA4 antibody was raised against synthetic peptide C-NSSANVPTEGFQF from the C-terminus of human KPNA4 (NP_002259.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bovine, Dog, Bat, Hamster, Elephant, Panda, Horse, Rabbit, Opossum (100%); Mouse, Rat, Turkey, Chicken, Platypus, Xenopus (92%); Zebrafish (85%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-QIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-QIP1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-QIP1 antibody    ELISA, IHC-P (5 ug/ml), WB (0.2 - 1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-QIP1 antibody    Anti-KPNA4 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-QIP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-QIP1 antibody    Antibody staining (0.5 ug/ml) of Human Testis lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.
anti-QIP1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for QIP1. It may not necessarily be applicable to this product.
 NCBI GI #    4504901
 NCBI GeneID    3840
 NCBI Accession #    NP_002259.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002268.4 [Other Products]
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 UniProt Secondary Accession #    O00190; A8K4S6; D3DNM2 [Other Products]
 UniProt Related Accession #    O00629 [Other Products]
 Molecular Weight    57,887 Da
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 NCBI Official Full Name    importin subunit alpha-3
 NCBI Official Synonym Full Names    karyopherin alpha 4 (importin alpha 3)
 NCBI Official Symbol    KPNA4 [Similar Products]
 NCBI Official Synonym Symbols   
QIP1; SRP3; IPOA3
[Similar Products]
 NCBI Protein Information    importin subunit alpha-3; importin alpha Q1; importin subunit alpha-4; karyopherin subunit alpha-4
 UniProt Protein Name    Importin subunit alpha-3
 UniProt Synonym Protein Names   
Importin alpha Q1; Qip1; Karyopherin subunit alpha-4
 UniProt Gene Name    KPNA4 [Similar Products]
 UniProt Synonym Gene Names    QIP1; Qip1 [Similar Products]
 UniProt Entry Name    IMA3_HUMAN
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 NCBI Summary for QIP1    The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]
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 UniProt Comments for QIP1    KPNA4: an alpha importin protein that functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Forms a complex with importin beta-1 subunit.

Protein type: Karyopherin; Nuclear import; Chaperone; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 3q25.33

Cellular Component: nucleoplasm; cytosol

Molecular Function: protein binding; protein transporter activity

Biological Process: response to hydrogen peroxide; cytokine and chemokine mediated signaling pathway; NLS-bearing substrate import into nucleus
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 Research Articles on QIP1    1. miR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin alpha4 and alpha5 in IgA nephropathy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-QIP1 antibodyPathways associated with anti-QIP1 antibody
 Reference Product  PubMed Publications
 KPNB1 antibody  >2 publications with QIP1 and KPNB1
 RCC1 antibody  >2 publications with QIP1 and RCC1
 TP53 antibody  >1 publications with QIP1 and TP53
 RECQL antibody  >1 publications with QIP1 and RECQL
 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Leptin Signaling Pathway antibodies  Leptin Signaling Pathway Diagram
Diseases associated with anti-QIP1 antibodyOrgans/Tissues associated with anti-QIP1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with QIP1 and Inflammation
 Necrosis Antibodies  >3 publications with QIP1 and Necrosis
 Lung Neoplasms Antibodies  >1 publications with QIP1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with QIP1 and Neoplasms, Experimental
 Learning Disorders Antibodies  >1 publications with QIP1 and Learning Disorders
 Liver Diseases Antibodies  >1 publications with QIP1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with QIP1 and Blood
 Lung Antibodies  >3 publications with QIP1 and Lung
 Brain Antibodies  >3 publications with QIP1 and Brain
 Skin Antibodies  >2 publications with QIP1 and Skin
 Muscle Antibodies  >2 publications with QIP1 and Muscle
 Vascular Antibodies  >2 publications with QIP1 and Vascular
 Lymph Node Antibodies  >1 publications with QIP1 and Lymph Node
 Liver Antibodies  >1 publications with QIP1 and Liver
 Stomach Antibodies  >1 publications with QIP1 and Stomach
 Intestine Antibodies  >1 publications with QIP1 and Intestine
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