NP_002259.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,887 Da
NCBI Official Full Name
importin subunit alpha-3
NCBI Official Synonym Full Names
karyopherin alpha 4 (importin alpha 3)
NCBI Protein Information
importin subunit alpha-3; importin alpha Q1; importin subunit alpha-4; karyopherin subunit alpha-4
UniProt Protein Name
Importin subunit alpha-3
UniProt Synonym Protein Names
Importin alpha Q1; Qip1; Karyopherin subunit alpha-4
UniProt Synonym Gene Names
UniProt Entry Name
IMA3_HUMAN
NCBI Summary for QIP1
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]
UniProt Comments for QIP1
KPNA4: an alpha importin protein that functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Forms a complex with importin beta-1 subunit.
Protein type: Chaperone; Karyopherin; Adaptor/scaffold; Nuclear import
Chromosomal Location of Human Ortholog: 3q25.33
Cellular Component: nucleoplasm; cytosol
Molecular Function: protein binding; protein transporter activity
Biological Process: response to hydrogen peroxide; cytokine and chemokine mediated signaling pathway; NLS-bearing substrate import into nucleus
Research Articles on QIP1
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Products associated with anti-QIP1 antibody
Pathways associated with anti-QIP1 antibody
Diseases associated with anti-QIP1 antibody
Organs/Tissues associated with anti-QIP1 antibody
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