Q96PU8.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Protein quaking
NCBI Official Synonym Full Names
QKI, KH domain containing, RNA binding
NCBI Protein Information
protein quaking; RNA binding protein HQK; quaking homolog, KH domain RNA binding; homolog of mouse quaking QKI (KH domain RNA binding protein)
UniProt Protein Name
Protein quaking
UniProt Synonym Gene Names
UniProt Entry Name
QKI_HUMAN
NCBI Summary for QKI
The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Comments for QKI
QKI: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor. 6 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 6q26
Cellular Component: cytoplasm; nucleus
Molecular Function: mRNA binding; protein binding; SH3 domain binding
Biological Process: regulation of translation; myelination; muscle cell differentiation; mRNA transport; RNA splicing; long-chain fatty acid biosynthetic process; vasculogenesis; mRNA processing; spermatid development
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Pathways associated with anti-QKI antibody
Diseases associated with anti-QKI antibody
Organs/Tissues associated with anti-QKI antibody
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