Q16769.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Glutaminyl-peptide cyclotransferase
NCBI Official Synonym Full Names
glutaminyl-peptide cyclotransferase
NCBI Official Synonym Symbols
NCBI Protein Information
glutaminyl-peptide cyclotransferase; EC; glutamyl cyclase; glutaminyl cyclase; glutaminyl-tRNA cyclotransferase
UniProt Protein Name
Glutaminyl-peptide cyclotransferase
UniProt Synonym Protein Names
Glutaminyl cyclase; QC; sQC; Glutaminyl-tRNA cyclotransferase; Glutamyl cyclase; EC
UniProt Synonym Gene Names
UniProt Entry Name
QPCT_HUMAN
NCBI Summary for QPCT
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
UniProt Comments for QPCT
QPCT: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. Belongs to the glutaminyl-peptide cyclotransferase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.3.2.5; Transferase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2p22.2
Molecular Function: glutaminyl-peptide cyclotransferase activity; zinc ion binding
Biological Process: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase; protein modification process
Research Articles on QPCT
Precautions
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Disclaimer
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Diseases associated with anti-QPCT antibody
Disease Name |
Pubmed Publications |
Inflammation Antibodies |
>2 publications with QPCT and Inflammation |
Brain Diseases Antibodies |
>1 publications with QPCT and Brain Diseases |
Nervous System Diseases Antibodies |
>1 publications with QPCT and Nervous System Diseases |
Fibrosis Antibodies |
>1 publications with QPCT and Fibrosis |
Kidney Diseases Antibodies |
>1 publications with QPCT and Kidney Diseases |
Neoplasms, Experimental Antibodies |
>1 publications with QPCT and Neoplasms, Experimental |
Hyperplasia Antibodies |
>1 publications with QPCT and Hyperplasia |
Disease Models, Animal Antibodies |
>1 publications with QPCT and Disease Models, Animal |
Hypertension Antibodies |
>1 publications with QPCT and Hypertension |
Leukemia, Lymphocytic, Chronic, B-Cell Antibodies |
>1 publications with QPCT and Leukemia, Lymphocytic, Chronic, B-Cell |
Organs/Tissues associated with anti-QPCT antibody
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